Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Infection by bacteriophage T4 has previously been shown to cause a rapid inhibition of the host recBC DNase, an ATP-dependent DNase that is required for genetic recombination in Escherichia coli. We report here the partial purification of a protein ("T4 rec inhibitor") from extracts of T4-infected cells and some characteristics of the in vitro inhibition reaction with purified inhibitor and recBC nuclease. This inhibitory activity could not be purified from extracts of uninfected E. coli. Both the ATP-dependent exonuclease and DNA-dependent ATPase activities of recBC DNase are inhibited by T4 rec inhibitor. Experiments suggest that the inhibitor interacts with the nuclease in a stoichiometric manner. The biological significance of this inhibition is discussed with respect to control reactions in phage-infected cells.
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PMID:Postinfection control by bacteriophage T4 of Escherichia coli recBC nuclease activity. 13 May 1

Infection of dogs with Echinococcus gramulosus is recorded for the first time in Kaduna State. Observations on 330 dogs from different suburbs revealed an incidence of 1.2 per cent. Of slaughtered stock examined, hydatid cyst infections were found in sheep (7.1 per cent), goats (18.4 per cent), cattle (1.5 per cent), camels (70.9 per cent) and pigs (5 per cent).
Vet Rec 1979 Apr 07
PMID:The epidemiology of echinococcus infection in Kaduna State, Nigeria. 55 94

The intravenous administration of whole blood from a pathologically confirmed field case of bovine malignant catarrhal fever (MCF) resulted in the appearance of the disease in three of five experimental calves 18 to 28 days later. Infection was maintained by serial calf transmissions, and produced clinical and pathological changes identical to those of the field disease for a total of 10 passages. The sixth passage involved the simultaneous infection of 10 calves from a single donor animal; six of the 10 recipients developed the typical disease after incubation periods ranging from 20 to 36 days and in each of these MCF was confirmed by pathological examination. In addition, clinical and pathological changes in the four other calves which were slaughtered either seven or 14 days post-infection suggested that they too would have developed typical clinical signs had they been allowed to survive for the necessary length of time. The results of a detailed study of the onset, progress and duration of the clinical signs of experimentally induced MCF are presented and the opportunity has been taken to discuss the available information regarding the transmission of MCF under experimental conditions and in the field.
Vet Rec 1978 Mar 25
PMID:Transmission studies with bovine malignant catarrhal fever. 64 23

An outbreak of Salmonella typhimurium in an upland sheep flock was characterised by rapid spread and heavy mortalities in ewes and young lambs. Clinical signs included diarrhoea and abortion. Abomasitis was the most striking and consistent post mortem lesion. Vaccination was the only control method that was apparently successful. Infection also occurred in the cattle, farm personnel, and a dog. Following the outbreak, pasture contamination and excreting cattle provided a reservoir of infection so that contamination of water courses and sporadic cases occurred over a year later.
Vet Rec 1976 Feb 14
PMID:An outbreak of S typhimurium in sheep and its consequences. 76 2

In 26 dogs treated surgically for urolithiasis, bacteriological examination of the urine and the interior of calculi showed that infection was present in both materials in 14 cases. Infection with phosphate calculi, present in 13 of these 14 dogs, was associated with a variety of bacteria including Staphylococcus aureus, Staph epidermidis, Streptococcus faecalis, Escherichia coli and Proteus spp. In a follow-up examination of 16 dogs, organisms different from the original isolates were recovered from some cases. The significance of the persistence of viable bacteria within canine bladder calculi is discussed.
Vet Rec 1975 Jul 19
PMID:Relationship of bacterial infection in urine and calculi to canine urolithiasis. 80 18

The effect of brucellosis on semen quality in rams was studied by means of artificially infecting five rams with a strain of Brucella ovis isolated in Kenya. Infection resulted in reduced semen quality including reduced total sperm output, poor motility and a high percentage of morphological abnormalities. Variation in semen quality both between and within rams appeared to be related to progress of the disease in the epididymis as well as to the distribution and severity of lesions in the reproductive tract.
Vet Rec 1976 Sep 18
PMID:Characteristics of semen changes during Brucella ovis infection in rams. 98 55

Antibodies to serotypes representing one or more of 10 Leptospira serogroups were detected in the sera of 1766 (49-1 per cent) cows and heifers out of a total of 3600 sera tested. Infection by the Hebdomadis serogroup was the predominant infection; antibodies to serotype sejroe were found in 1503 (41-8 per cent) sera. Antibodies to the Icterohaemorrhagiae (7-7 per cent) and Balllm (7-3 per cent) serogroups were the next most common, while antibodies to the Australis, Javanica, Canicola, Panama, Cynopteri, Pyrogenes and Autumnalis serogroups were detected in a small number of animals. Only the Hebdomadis and Icterohaemorrhagiae serogroups were associated with clinical disease.
Vet Rec 1976 Nov 13
PMID:Bovine leptospirosis: a serological and clinical study. 99 82

A blood sample received from a field case of redwater in Eire caused simultaneous infections of Babesia divergens and Ehrlichia phagocytophila when inoculated into a splenectomised calf. Each disease agent was isolated in a separate splenectomised calf by suppressive drug treatment of the other agent, and blood stabilates were made. The disease agents were inoculated synchronously or asychronously into groups of calves, whose reactions were observed. Infection with B divergens had no effect on the severity of reaction of the calves to E phagocytophila but E phagocytophila infection tended to delay the establishment of B divergens if inoculated simultaneously or one week previously. If the inoculations were simultaneous there was also a tendency for the B divergens infection to be partially or completely suppressed. There was no evidence of recrudescence of one infective agent when the other was inoculated one month later.
Vet Rec 1976 Nov 20
PMID:Separation and recombination of Babesia divergens and Ehrlichia phagocytophila from a field case of redwater from Eire. 100 62

Faeces samples from 11 sows and their litters and intestinal contents and scrapings collected from 56 piglets at the time of slaughter were examined for Isospora suis. The findings indicate that oocysts with sporoblasts can be found in faeces samples 24 hours after collection; the prepatent period is about six to nine days and the patent period three to eight days (adjudged under non-experimental conditions); piglets in an infected herd are normally resistant to natural infection for the first three weeks of life. Infection is followed by the development of an active immunity which is not affected by the stress of farrowing.
Vet Rec 1976 Apr 17
PMID:Observations on Isospora suis infection in a minimal disease pig herd. 127 45

Five mature bulls were studied during an acute transient infection with bovine viral diarrhoea virus (BVDV). The bulls had been infected experimentally by the intranasal instillation of blood and serum from a cow which was a persistent carrier of the virus. Infection was confirmed by the demonstration of a low titred viraemia in four of the five animals and by the seroconversion of all five. Semen samples were collected from each bull on four occasions between seven and 14 days after infection. The virus was isolated from the semen of three of the five bulls and from nine of 12 batches of semen from them. In contrast to other studies of the infection of semen, BVDV was isolated with similar efficiency from raw, unprocessed semen and from diluted, extended semen. The titres of virus in the semen ranged from 5 to 75 TCID50/ml. The infection did not appear to affect the quality of the semen. Shedding of virus continued after the end of the period of viraemia and appeared to be a consequence of the replication of the virus in the reproductive tract and its subsequent excretion in the seminal fluid. Virological studies of the reproductive tracts of these bulls suggested that the most productive sites of virus replication were the seminal vesicles and the prostate gland. Concurrent studies in a persistently infected bull supported these findings.
Vet Rec 1991 Jun 22
PMID:Replication of bovine viral diarrhoea virus in the bovine reproductive tract and excretion of virus in semen during acute and chronic infections. 165 60


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