Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The clinical, radiological and pathological findings in a natural outbreak of rickets affecting 82 pigs are described. An interesting feature was the presence of gross articular abnormalities including resorption of subchondral bone with folding and ulceration of the articular cartilage. The diet was deficient in calcium and vitamin D. A diagnosis of rickets complicated by nutritional secondary hyperparathyroidism was made. The results of treatment and the economics of the outbreak are discussed.
Vet Rec 1978 Jul
PMID:Rickets in growing pigs and response to treatment. 67 16

The most commonly encountered nutritional bone disease is nutritional secondary hyperparathyroidism. This is primarily of importance in the dog but is occasionally seen in kittens, particularly of the Siamese breed, and is often associated with the feeding of owner compiled, meat-rich diets. Classic rickets is now a rare clinical entity. Hypertrophic osteodystrophy is regularly seen in the larger breeds of dog and the aetiology remains obscure. Hypervitaminosis A associated with liver-rich diets is often encountered in the cat. Hypovitaminosis A has been described but its true clinical significance is unknown.
Vet Rec 1976 Apr 17
PMID:Nutrition and bone disease in the dog and cat. 77 53

Metabolic bone disease was diagnosed in an 11-month-old female common marmoset (Callithrix jacchus). It was depressed, reluctant to move, and was cachectic and small for its age. Laboratory findings included anaemia, azotaemia and an inverse calcium to phosphorus ratio. The radiological findings showed simultaneous signs of osteomalacia and soft-tissue calcification. There was decreased bone density with lytic areas in the pelvis and femur, and severe bilateral nephrocalcinosis. Postmortem examination revealed marked focal dystrophic calcification of the epi- and myocardium. Calcium and vitamin D3 deficiency (nutritional secondary hyperparathyroidism) was the most likely cause of the osteomalacia.
Vet Rec 1998 Jul 18
PMID:Unusual case of metabolic bone disease in a common marmoset (Callithrix jacchus). 971 24

Two privately owned domestic skunks (Mephitis mephitis) developed clinical signs of hyperparathyroidism. Survey radiographs, complete blood counts and biochemical profiles, including the concentrations of ionised calcium, parathyroid hormone and 25-(OH)-vitamin D, established that they were deficient in vitamin D and had secondary nutritional hyperparathyroidism. They both responded to treatment, as well as to changes in their diet, and levels of exercise and exposure to sunlight.
Vet Rec 2004 Aug 21
PMID:Secondary nutritional hyperparathyroidism associated with vitamin D deficiency in two domestic skunks (Mephitis mephitis). 1538 5