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One hundred and twenty four-month-old Hereford-Friesian cross heifers weighing from 88 to 130 kg were divided into two equal groups. One group acted as a control with each animal receiving one placebo bolus, the other animals received one prototype intraruminal sustained-release bolus designed to deliver approximately 8 mg ivermectin/day for 100 to 120 days. The boluses were administered the day before turnout in mid-May. Each group was grazed separately for 167 days on pastures contaminated with parasitic nematode larvae including the lungworm Dictyocaulus viviparus, and the gastrointestinal worms Ostertagia ostertagi, Cooperia oncophora and Nematodirus helvetianus. Parasitic disease did not occur in the ivermectin-bolus group, but the control group required anthelmintic treatment to control parasitic gastroenteritis at 111 and 154 days after turnout. Up to the 111th day after turnout, the peak mean nematode egg and larval counts per gram of faeces in controls was, respectively, 564 epg and 0.5 lpg. Based on faecal nematode egg counts and worm burdens in bolus-treated cattle removed from pasture at 119 days after turnout and bolus function studies, it was concluded that ivermectin delivery from the prototype bolus ceased between 95 and 98 days after administration. However, unlike the controls, the treated cattle did not develop parasitic gastroenteritis at any time. Their faecal nematode egg output was significantly (P < 0.01) lower (< 1 epg) compared to the controls and lungworm larval output zero during the functional life of the bolus. The faecal egg and larval outputs continued low until the end of the trial.(ABSTRACT TRUNCATED AT 250 WORDS)
Vet Rec 1994 Nov 19
PMID:Nematode burdens and productivity of grazing cattle treated with a prototype sustained-release bolus containing ivermectin. 787 90

The efficacy of orally administered moxidectin was determined against four benzimidazole-resistant nematode isolates. At the start of the trial, 30 lambs were each infected experimentally with 20,000 third stage larvae (5000 Haemonchus contortus, 7000 Teladorsagia circumcincta, 3000 Trichostrongylus colubriformis and 5000 Cooperia curticei); 28 days later they were allocated randomly to three groups of 10: one untreated group, one group treated orally with fenbendazole (5 mg/kg bodyweight) and one group treated orally with moxidectin (0.2 mg/kg). Samples of faeces were taken five and 10 days after treatment and the lambs were killed 10 days after treatment. Fenbendazole reduced the average number of nematode eggs in faeces by 95 per cent and the average number of worms by 25 to 45 per cent according to the species. The efficacy of moxidectin against these benzimidazole-resistant isolates was 100 per cent. No adverse reactions to either of the drugs were observed.
Vet Rec 1995 Jan 07
PMID:Efficacy of oral moxidectin against benzimidazole-resistant isolates of gastrointestinal nematodes in sheep. 790 Feb 56

The intestinal tracts of 363 horses were examined after slaughter at a horse abattoir. The presence or absence of Anoplocephala perfoliata and the sites of attachment were recorded. A total of 51 per cent of the horses had A perfoliata attached to the mucosa of the ileocaecal junction and/or to the caecal mucosa; 5 per cent of the horses had A perfoliata attached only to the mucosa of the ileocaecal junction, 24 per cent had A perfoliata attached only to the caecal mucosa and 22 per cent of the horses had A perfoliata attached at both sites. The degree of infestation did not appear to be influenced by the season or by the age, breed or source of origin of the horses. The lesions at the sites of attachment included congestion, oedema, ulceration, diphtheresis, mucosal thickening, eosinophil infiltration and fibroplasia. The severity of the lesions was exacerbated by increasing numbers of worms.
Vet Rec 1994 May 14
PMID:Incidence of Anoplocephala perfoliata in horses examined at an Irish abattoir. 808 8

The activity of morantel citrate (5.94 mg/kg base) was determined in laboratory tests against field isolates of benzimidazole-resistant nematodes. Its efficacies against adult and seven-day-old worms were 100 per cent and 100 per cent for Cooperia curticei, 95.1 per cent and 69.8 per cent for Haemonchus contortus and 100 per cent and 82 per cent for Ostertagia circumcincta. Morantel citrate was 100 per cent effective against benzimidazole-susceptible Nematodirus battus and Trichostrongylus vitrinus, and it reduced faecal egg counts by 97.9 per cent in sheep infected naturally with benzimidazole-resistant H contortus and O circumcincta.
Vet Rec 1993 Aug 14
PMID:Activity of morantel citrate against strains of benzimidazole-resistant nematodes of sheep in the United Kingdom. 823 1

To determine whether there is mutual resistance to avermectin and milbemycin anthelmintics, ivermectin and moxidectin sheep drenches were tested against ivermectin-resistant and susceptible isolates of Ostertagia circumcincta and Trichostrongylus colubriformis in sheep. None of the isolates had been exposed to moxidectin previously. The dosage of ivermectin required to remove 95 per cent of the ivermectin-resistant O circumcincta and T colubriformis were 23 times and six times larger, respectively, than the dosages required to remove the same percentage of susceptible isolates. The dosages of moxidectin required to remove 95 per cent of the ivermectin-resistant O circumcincta and T colubriformis were 31 times and nine times larger, respectively, than the dosages required to remove the same percentage of susceptible isolates. It is concluded that the worms resistant to ivermectin were also resistant to moxidectin.
Vet Rec 1993 Oct 30
PMID:Mutual resistance to avermectins and milbemycins: oral activity of ivermectin and moxidectin against ivermectin-resistant and susceptible nematodes. 829 Nov 74

Angiostrongylus vasorum infection was diagnosed in six dogs by the identification of larvae in sputum or faeces, or by the identification of adult worms post mortem. In another dog strong evidence of the condition was obtained but no parasites were identified. In four cases the main clinical signs were coughing and dyspnoea, but one dog had exercise intolerance and no history of coughing. One dog in which larvae were found in the faeces had no clinical signs that were related to the infection. Another dog had flaccid hindlimb paralysis and forelimb hypermetria-clinical signs of the disease which have not been reported previously. Four of the cases came from south Wales, one of them being the first case of the infection to be reported from this area.
Vet Rec 1993 Dec 04
PMID:Angiostrongylus vasorum infection in seven dogs. 830 6

Eight controlled trials were conducted, using 96 cattle of European breeds, to evaluate the efficacy of abamectin against natural and artificially acquired infections of adult and fourth-stage larvae of all the economically important gastrointestinal nematodes and lungworms in Germany and the United Kingdom. Half the animals were treated on one occasion with abamectin at a dose of 200 micrograms/kg bodyweight given subcutaneously while the other half remained untreated. Worms were counted 14 or 21 days after treatment or 28 days after the last infection. The treatment was highly effective (> 99 to 100 per cent) (P < 0.05) at removing immature (L4) stages and adult worms of the following species: Ostertagia ostertagi (inhibited larvae included), Trichostrongylus axei, Haemonchus contortus, Bunostomum phlebotomum, Cooperia species Oesophagostomum radiatum and Dictyocaulus viviparus. Naturally acquired adult C surnabada and Trichuris discolor infections were also significantly (P < 0.05) reduced. For Nematodirus helvetianus the efficacy varied from 89.8 to > 99 per cent (P > 0.1 to < 0.01). Abamectin gave full protection against the gastrointestinal nematodes O ostertagi, H contortus, Cooperia species and O radiatum for at least seven days and against the lungworm D viviparus for at least 14 days after treatment.
Vet Rec 1993 Jan 09
PMID:Efficacy of abamectin against nematodes in cattle. 844 34

The intestinal tracts of 20 horses, killed at a local abattoir and of unknown age, sex and previous clinical history were examined for the presence of Anoplocephala perfoliata attached to the ileo-caecal junction. Four horses had no tape-worms, nine had one to 20 tapeworms attached to the mucosa and seven had more than 100 attached to the mucosa. The histological changes of thickening, ulceration and eosinophil infiltration of the mucosa at the ileo-caecal junction were more severe when more than 100 parasites were present.
Vet Rec 1993 Feb 20
PMID:Pathological lesions associated with Anoplocephala perfoliata at the ileo-caecal junction of horses. 845 1

In a controlled trial with 32 calves on the persistence of the effect of a 0.5 mg/kg moxidectin pour-on against cattle nematodes the following periods of persistence were observed: Virtually 100 per cent efficacy for more than five weeks against Dictyocaulus viviparus (total numbers and juveniles) and Ostertagia species (total numbers, inhibited early fourth stage larvae [L4] and juveniles); over 97 per cent for more than four weeks against Trichostrongylus axei (total numbers, inhibited early third stage larvae [L3] and juveniles); 100 per cent for more than two weeks against T vitrinus (total numbers and inhibited early L3), and more than 90 per cent against Cooperia species (total numbers and inhibited early L4), and 89 per cent against L4 of Nematodirus species. Moxidectin thus had a more persistent effect against worms from the lungs and the abomasum than against worms from the small intestine, particularly because differences were observed between Trichostrongylus species from both locations. The population dynamics of T axei and T vitrinus in the calves appeared to differ from that in sheep. The relatively high percentages of inhibited early L3 in the untreated calves suggest that there was a much stronger tendency for a seasonal pattern of inhibition than in sheep.
Vet Rec 1995 Oct 28
PMID:Persistence of the effect of a moxidectin pour-on against naturally acquired cattle nematodes. 856 Jul 14

A survey in 1992 showed that 44 per cent of the sheep farms tested in the south west and 15 per cent of those in the north east of England had parasitic nematode worm burdens which were resistant to benzimidazole anthelmintics, and that 65 per cent of the non-dairy goat farms tested in England and Wales had resistant worms. Ostertagia circumcincta was the main species in sheep and Haemonchus contortus in goats. The resistance to benzimidazoles was diagnosed by a combination of an egg hatch assay and a larval development test. A simplified faecal egg count reduction test was used to investigate sheep and goat farms for signs of ivermectin resistance but no positive cases were detected. The initial identification of levamisole resistance on one farm, both from a faecal egg count reduction test and a positive larval development test, was confirmed by a 'dose and slaughter' trial.
Vet Rec 1996 Jul 27
PMID:Occurrence of anthelmintic resistant nematodes on sheep farms in England and goat farms in England and Wales. 884 38


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