Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A flock of broiler chickens was monitored intensively for overt signs indicative of sudden death. Electrocardiographic tracing of terminal cardiac activity was obtained from six broilers succumbing to sudden death syndrome and from six control chickens which were killed by cervical dislocation. Normal sinus rhythm, heart rate and electrocardiogram (ECG) pattern with P, QRS, and T deflections were observed for two to three minutes in the control chickens. The ECG tracing from birds dying of sudden death syndrome showed no identifiable P, QRS, or T waveforms. Initial more regular oscillatory waves resembling ventricular flutter, changed to irregular, undulating waves characteristic of ventricular fibrillation. A straight line, indicating cessation of heart activity, appeared within four to six minutes of the onset of clinical signs. It was concluded that the sudden death syndrome is associated with an acute cardiovascular failure caused by a lethal cardiac dysrhythmia, ventricular fibrillation.
Vet Rec 1997 Feb 15
PMID:Malignant ventricular dysrhythmia in broiler chickens dying of sudden death syndrome. 905 95

A five-year-old warmblood mare with atrial fibrillation was treated with quinidine sulphate. The atrial rhythm changed to atrial flutter and, because there were toxic effects, the treatment was discontinued. Seven months after the occurrence of the atrial flutter, treatment with a rapid atrial pacing technique restored a normal sinus rhythm. One year after the pacing therapy the horse was still in sinus rhythm and had been brought back into training.
Vet Rec 1998 Mar 21
PMID:Intracardiac overdrive pacing as a treatment of atrial flutter in a horse. 956 96

Echolocating bats have adaptations of the larynx such as hypertrophied intrinsic musculature and calcified or ossified cartilages to support sonar emission. We examined growth and development of the larynx relative to developing flight ability in Jamaican fruit bats to assess how changes in sonar production are coordinated with the onset of flight during ontogeny as a window for understanding the evolutionary relationships between these systems. In addition, we compare the extent of laryngeal calcification in an echolocating shrew species (Sorex vagrans) and the house mouse (Mus musculus), to assess what laryngeal chiropteran adaptations are associated with flight versus echolocation. Individuals were categorized into one of five developmental flight stages (flop, flutter, flap, flight, and adult) determined by drop-tests. Larynges were cleared and stained with alcian blue and alizarin red, or sectioned and stained with hematoxylin and eosin. Our results showed calcification of the cricoid cartilage in bats, represented during the flap stage and this increased significantly in individuals at the flight stage. Thyroid and arytenoid cartilages showed no evidence of calcification and neither cricoid nor thyroid showed significant increases in rate of growth relative to the larynx as a whole. The physiological cross-sectional area of the cricothyroid muscles increased significantly at the flap stage. Shrew larynges showed signs of calcification along the margins of the cricoid and thyroid cartilages, while the mouse larynx did not. These data suggest the larynx of echolocating bats becomes stronger and sturdier in tandem with flight development, indicating possible developmental integration between flight and echolocation.
Anat Rec (Hoboken) 2014 Jul
PMID:Ontogeny of the larynx and flight ability in Jamaican fruit bats (Phyllostomidae) with considerations for the evolution of echolocation. 2477 87