Gene/Protein Disease Symptom Drug Enzyme Compound
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Parturition was induced, on day 278 of pregnancy, of identical twin male Blonde d'Aquitaine calves; the parturition was assisted by gentle traction. The calves died approximately four minutes and eight hours after birth. Detailed post mortem examinations revealed soft tissue haemorrhage, fractured ribs and intrapulmonary amniotic material. The calf which lived for four minutes had persistent fetal atelectasis and a solitary cartilage embolus in a meningeal vein. Atrioventricular valvular telangiectases were incidental findings in both calves. The observations suggest first that parturient trauma may contribute to neonatal mortality, secondly that the need for intensive neonatal care may be greater than is usually considered appropriate, thirdly that a post mortem examination may reveal unexpected lesions whose effects may contribute to the calves' failure to thrive, and finally that a critical assessment of neonatal pathology is restricted by the lack of data on the perinatal physiological status of the bovine dam and fetus.
Vet Rec 1993 Nov 06
PMID:Neonatal mortality in a pair of identical twin calves: clinical and post mortem observations. 811 64

A study of four marine salmon farms was undertaken in Ireland in 2008, with a focus on gill health and disease. All four farms suffered severe gill disease resulting in mortalities and, in some cases, failure to thrive. The aetiology of the gill pathologies in some cases was associated with small gelatinous zooplankton and bacteria, but also involved epitheliocystis and parasites such as marine costia (Ichthyobodo species) and amoebae (Neoparamoeba species). Treatments with oral broad-spectrum antibiotics and/or freshwater baths had equivocal benefits. There was a strong association of susceptibility to gill disease with one genetic strain of salmon.
Vet Rec 2011 Jun 25
PMID:Gill disease in marine farmed Atlantic salmon at four farms in Ireland. 2165 58

Porcine periweaning failure to thrive syndrome (PFTS) can be defined by anorexia, lethargy, progressive debilitation and compulsive behaviours that occur in seemingly healthy pigs within two to threeweeks of weaning in the absence of any known infectious, nutritional, management or environmental factors. A genetic component has been hypothesised for this syndrome. In the present study, 119 commercial pigs (80 cases and 39 controls) were genotyped with the porcine 80K single nucleotide polymorphism-chip and were analysed with logistic regression and two Fixation Index-based approaches. The analyses revealed several regions on chromosomes 1, 3, 6 and 11 with moderate divergence between cases and controls, particularly three haplotypes on SSC3 and 11. The gene-based analyses of the candidate regions revealed the presence of genes that have been reported to be associated with phenotypes like PFST including depression (PDE10A) and intestinal villous atrophy (CUL4A). It is important to increase the effort of collecting more samples to improve the power of these analyses.
Vet Rec 2018 07 21
PMID:Genomic investigation of porcine periweaning failure to thrive syndrome (PFTS). 3002 56