Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Polarised light biomicroscopy was used to examine the normal pre-corneal tear film in 21 eyes of 12 pekingese dogs. The purpose of the study was to examine the influence of excessive exophthalmos on the pre-corneal tear film in the dog. The majority of the animals were found to have high levels of ocular surface contamination by particulate material and plaques of viscous mucus. Other abnormalities included surface lipid with an abnormal granular (three dogs) or 'curdled' (two dogs) appearance; excessive thinning of the lipid layer of the tear film; and the presence of dark globular structures in two dogs, which were presumed to be abnormal meibomian lipid. Break up of the tear film was observed in one dog. Grossly, a thread of viscous mucus was frequently observed along the margin of the lower eyelid. It is postulated that this thread forms because of the excessively exophthalmic conformation of the breed, which prevents the normal access of effete mucus and entrapped debris to the lower conjunctival fornix. The combination of the above factors in the pekingese is suggested as the mechanism whereby the tear film has a reduced stability, thus enhancing the risk from factors more usually considered to initiate corneal ulceration in the breed. The possible adverse effects of lid splitting for the mass removal of distichiae in exophthalmic dogs is discussed.
Vet Rec 1989 Apr 01
PMID:Biomicroscopy of the tear film: the tear film of the pekingese dog. 271 23

Eye abnormalities in reared gilthead sea bream (Sparus aurata) were investigated clinically and by histological techniques. A significant number of fish had a cataract in one eye and ocular inflammation including gross exophthalmos. In a small number of fish gas bubbles were observed in the anterior chamber of the eye. Histological examination provided no evidence of an infectious process and a possible behavioural aetiology is discussed.
Vet Rec 1999 Oct 23
PMID:Unilateral eye abnormalities in reared Mediterranean gilthead sea bream. 1059 72

The oral cavities of 65 rabbits, 35 chinchillas, 38 guinea pigs, 19 degus and 13 prairie dogs suffering from a lack of appetite, hypersalivation, moist dermatitis, swelling of the lower jaw or mild exophthalmos were examined with a paediatric laryngoscope and rigid endoscope. The laryngoscope was safe and satisfactory for a preliminary examination, but changes in the less accessible caudal parts of the cavity could not be identified precisely. A rigid endoscope with 30 degrees optics made it possible to examine all parts of the oral cavity and oropharynx, and make detailed observations of surface lesions on the premolar and molar teeth and the mucosal surface of the gingiva, tongue and hard palate; endoscopy with 70 degrees optics provided an excellent view of the occlusal tooth surfaces, tooth crowns, and buccal mucosa. The collection of biopsy samples, the removal of foreign objects and the correction of malocclusions were greatly simplified by the use of the endoscope owing to the clear visualisation of the procedures, and the risk of injury was minimised. The examinations with a laryngoscope were made effectively on animals that were manually restrained, but a thorough examination with a rigid endoscope required the animals to be anaesthetised.
Vet Rec 2007 Jan 06
PMID:Evaluation of a laryngoscope and a rigid endoscope for the examination of the oral cavity of small mammals. 1720 89

Sixty-six guinea pigs with dental disease were presented to the University of Veterinary Medicine, Vienna, Austria, from 2006 to 2010. Almost all patients had a history of eating difficulties (95 per cent) and underwent clinical and oral examination as well as CT of the head. Findings on extra- and intraoral examination were asymmetric elongation (n=28) and symmetric bridging (n=24) of cheek teeth, obliquely worn incisors (n=17), palpable lower jaw swellings (n=13), exophthalmos (n=10) and incisor macrodontia (n=6). Eighty per cent of guinea pigs with exophthalmos showed ipsilateral periapical disease of the maxillary cheek teeth on CT. Ninety-two per cent of patients with palpable lower jaw swellings showed corresponding dental pathologies on CT. Periapical disease of incisors (n=11) and cheek teeth (n=32) were the most common findings on CT. All abnormally large incisors were found on oral examination and CT, but macrodontia of cheek teeth could only be visualised by CT. Deviation of the lower jaw evaluated in awake animals by visual inspection appeared to correlate with cheek teeth abnormalities. Results emphasise the importance of diagnostic imaging, in particular CT, in guinea pigs with dental disease in order to localise lesions and underlying aetiologies.
Vet Rec 2014 Nov 29
PMID:The role of computed tomography in the assessment of dental disease in 66 guinea pigs. 2505 48