Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A non-suppurative encephalitis accompanied by intraneuronal intranuclear inclusions were observed in the brain from a cow that died within 10 hours of developing nervous signs. Immunogold-silver staining located Aujeszky's disease virus antigen in neuronal cytoplasm and the virus was isolated from large volumes of suspensions of nervous tissues and tonsils. Fattening pigs in adjacent buildings had high antibody titres to Aujeszky's disease virus. The methods by which the cow could have acquired infection are considered, and the significance of transient low titres of antibodies to Aujeszky's disease virus in in-contact cows is discussed.
Vet Rec 1990 Jan 06
PMID:Aujeszky's disease in a cow. 231 72

During a period of seven months in 1982-83 cases of postvaccinal encephalitis were recorded in dogs in various parts of Britain after the administration of a particular batch of combined distemper/hepatitis vaccine. Detailed investigations of one of these cases revealed that the distemper component was responsible and the vaccine virus was recovered from the brain of an affected dog.
Vet Rec 1988 Jan 16
PMID:Encephalitis in dogs associated with a batch of canine distemper (Rockborn) vaccine. 289 28

Maedi-visna has never been recorded in Australia. However, caprine retroviruses have been isolated which cause clinical disease similar to caprine arthritis-encephalitis and produce antibodies in goats similar to those caused by maedi-visna virus. Merino lambs in close contact for up to 109 weeks with three goats experimentally infected with a caprine retrovirus did not seroconvert or show any significant pathological lesions. No viruses were isolated from any of these sheep though the goats seroconverted and two out of the three developed a non-suppurative bursitis and arthritis. Merino lambs inoculated with a caprine retrovirus showed no significant clinical signs or pathological lesions over a period of 140 weeks though nine out of the 12 seroconverted and viraemia was demonstrated in seven.
Vet Rec 1985 Jul 20
PMID:Response of merino sheep to inoculation with a caprine retrovirus. 299 5

The results of serological testing for maedi-visna virus infection in indigenous and non-indigenous sheep in Northern Ireland, over a five year period (1980 to 1984) are presented. In tests carried out in 1980 and 1981 on pedigree breeds, 10 reactors were identified on seven farms and maedi-visna virus was isolated on three occasions from leucocyte cultures. None of the animals showed clinical signs of maedi-visna and all the reactors were subsequently destroyed. Nine of the reactors were imports from Scotland or the Republic of Ireland and the other was the progeny of an imported ewe. In subsequent tests (1982 to 1984) of exotic and indigenous flocks no further reactors were identified. A survey of goat herds for evidence of caprine arthritis-encephalitis virus infection was also negative.
Vet Rec 1986 Apr 12
PMID:Serological surveillance for maedi-visna virus and caprine arthritis-encephalitis virus in Northern Ireland. 301 May 39

A goat herd severely affected by arthritis was studied. The most representative clinical signs consisted of articular swelling, mainly of the carpal joints, and the subsequent locomotor disorders. Some goats also showed signs of central nervous system involvement. Examinations of joint fluid revealed an increased number of mononuclear blood cells, mostly lymphocytes. Gross and microscopic articular lesions were of inflammatory and degenerative types. Periarticular connective tissue, synovial bursae, tendons and tendon sheaths were predominantly affected. Inflammatory lesions were those of a chronic hyperplastic tenosynovitis with fibrosis of the connective tissue components. Degenerative changes consisted mainly of necrosis and mineralisation of articular-related structures. Histological lesions in the central nervous system were those of a nonpurulent encephalitis initially located in periventricular areas, but in one case extensive encephalomalacia was also seen. Of the 80 animals sampled 82.5 per cent showed seropositive reactions against an ovine progressive pneumonia virus antigen. None was seropositive to brucella and titres to chlamydia were low. Attempts to isolate chlamydia and mycoplasma from affected joints and several organs failed. Different bacteria were recovered from a few samples but did not seem significant. Syncytium-forming viral particles were isolated from several organs, mainly the lungs, synovial membranes and lymphoid tissue of almost all the slaughtered animals. These particles were identified as lentiviruses by electron microscopy. The clinical signs, lesions serological results and microbiological findings, led to a diagnosis of caprine arthritis-encephalitis. This syndrome has not been recognised in Spain previously.
Vet Rec 1987 Jan 31
PMID:Caprine arthritis-encephalitis in the Basque country, Spain. 303 62

Six 34- to 42-day-old lambs raised in coccidia-free conditions were inoculated with 70,000 sporocysts derived from sheep heart with microscopic sarcocysts. Fever and mild anorexia occurred between 25 and 33 days after inoculation. A transient anaemia was most marked 32 days after inoculation. Lambs were killed and examined 14, 25, 33, 42, 60 and 81 days after inoculation. Gross lesions were absent. First and second generation meronts were present in endothelial cells at 25 and 33 days after inoculation. Meronts were most numerous in kidney glomeruli. Developing sarcocysts were rare at 42 days after inoculation. Sarcocysts with a primary cyst wall 2 to 3 micron thick composed of palisade projections were common at 60 and 81 days after inoculation in striated muscle and brain. Mild to severe striated muscle myositis and non-suppurative encephalitis or encephalomyelitis with glial nodules were observed 25 to 81 days after inoculation. Sarcocyst frequency varied considerably; it was highest in myocardium, M vastus intermedius, M vastus medialis, M extensor carpi radialis and tongue muscle and was lowest in M masseter.
Vet Rec 1986 Nov 22
PMID:Experimental microcyst sarcocystis infection in lambs: pathology. 310 Dec 71

An outbreak of listeric meningo-encephalitis occurred in a population of 1800 fallow deer (Dama dama) in a park during the winter and early spring of 1985 to 1986. Listeriosis was diagnosed in 41 of 42 fallow deer that showed the typical central nervous system signs of circling disease or were found dead. The diagnosis was verified by bacteriological examination of the brains of 35 animals. In five of the seven remaining cases listeriosis was diagnosed by histological examination, and in one animal by clinical signs alone. Listeria monocytogenes was isolated in three of 23 soil samples taken from the park. In addition, L monocytogenes was isolated from the intestinal contents of apparently normal fallow deer. Fifty isolates from animals and soil were serotyped and all of them belonged to serovar 4b except one from brain (serovar 1/2b) and three from intestinal contents (serovar 1/2a). In phage typing of 54 isolates, the 35 isolates from the brain and spleen of diseased animals belonged to the same lysovar, as did most isolates from other sources, but strains from intestinal contents belonged to three other phage types. No external source of L monocytogenes was demonstrated in the outbreak and stress due to the poor beech-mast crop, an increased stocking rate and a sudden change in the weather are suspected as predisposing factors.
Vet Rec 1988 Mar 19
PMID:An outbreak of meningo-encephalitis in fallow deer caused by Listeria monocytogenes. 313 46

A retrospective study of 75 sheep flocks affected with listeriosis during January to June 1982 was made. Seven flocks experienced more than one form of listeriosis. Encephalitis was the commonest form, occurring in 60 flocks, and only lambs were affected in 10 of these flocks. In the remaining 50 flocks only single cases in adults were recorded in eight flocks. The mean attack rate for encephalitis in adults was 2.5 per cent. Listeric abortions occurred in 18 flocks and was the only form of listeriosis in 13 flocks. Silage was fed in 59 of the affected 60 flocks. A significant association between silage feeding and the development of listeric encephalitis was found in these flocks with the estimated relative risk being 3.8. Winter housing was not found to be associated with the development of listeric encephalitis.
Vet Rec 1986 Nov 08
PMID:Epidemiology of ovine listeriosis in Great Britain. 378 10

One hundred and ninety-six housed pregnant ewes were fed poor quality silage for two days. Ewes are reluctant to eat the silage and within 48 hours they became dull and developed diarrhoea and lameness. Despite treatment with antibiotics and calcium borogluconate 19 ewes died, more than 60 developed vaginal discharges and at lambing 94 ewes were barren. Six developed nervous signs and two of these died, one with lesions typical of listeric encephalitis. Post mortem lesions and the isolation of Listeria monocytogenes type 1/2 from lung, liver, spleen and kidney are described. L monocytogenes was also isolated from blood samples from live ewes. The estimated gross financial loss to the farmer was 5130 pounds or, for the flock, 26 pounds per ewe.
Vet Rec 1985 Feb 09
PMID:Septicaemia, encephalitis and abortions in a housed flock of sheep caused by Listeria monocytogenes type 1/2. 392 Aug 13

Analysis of field data suggested that listerial encephalitis in sheep was most common in winter and early spring in the age groups of sheep which would be cutting, changing and possibly losing teeth. It was hypothesised that under these conditions ingested Listeria monocytogenes could reach the fine dental terminals of the trigeminal nerve causing an ascending neuritis and encephalitis. Experimental inoculation of organisms into the dental pulp demonstrated the feasibility of this route of infection. Histological encephalitis was evident six days after inoculation but the incubation period to clinical neurological disease was at least three weeks.
Vet Rec 1985 Mar 02
PMID:Ovine listerial encephalitis: analysis, hypothesis and synthesis. 400 94


1 2 3 4 Next >>