Gene/Protein Disease Symptom Drug Enzyme Compound
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The specifity of a direct fluorescent antibody test for the detection of pathogenic Treponema hyodysenteriae associated with swine dysentery was improved by absorbing the original conjugated serum with a non pathogenic treponeme.
Vet Rec 1977 Oct 08
PMID:Diagnosis of swine dysentery using an absorbed fluorescent antiserum. 33 34

The minimum inhibitory concentration (MIC) of dimetridazole (DMZ) against Treponema hyodysenteriae (55 isolates) obtained over the period 1974-77 from individual pigs with swine dysentery from 41 herds where DMZ had been in use was determined. The MIC was less than or equal to 5.0 microgram per ml for 54 of the isolates and differences in the distribution of MICs between the annual sampling periods were not significant (P less than 0.05). There was no decrease in sensitivity of T hyodysenteriae to DMZ during the survey.
Vet Rec 1979 Jan 27
PMID:Sensitivity in vitro to dimetridazole of treponemes associated with swine dysentery. 43 15

Thirty-one strains of spirochaetes from pigs and two strains from poultry were tested in the API ZYM enzyme system. The spectrum of enzymatic reactions provided a means of differentiating between strains related to swine dysentery and strains not so related from pigs. The numerical coding system simplified the interpretation of the results.
Vet Rec 1979 Apr 28
PMID:An evaluation of the API ZYM system as a means of classifying spirochaetes associated with swine dysentery. 47 37

A disc growth-INHIBITION (GI) test was developed for differentiating Treponema hyodysenteriae from other intestinal spirochaetes. Tests with antisera against six spirochaetes, including two strains of T hyodysenteriae revealed four serological types among the six strains. The two strains of T hyodysenteriae represented one type. The test was specific in that there were no cross-reactions between the four types. Using antisera to two strains of T hyodysenteriae, it was possible to distinguish 11 strains isolated from cases of swine dysentery from nine other intestinal spirochaetes, seven from pigs, one from a cat and one from a chicken. The GI test seems to have potential as a simple, specific screening test for T hyodysenteriae.
Vet Rec 1979 Jun 16
PMID:A disc growth-inhibition test for differentiating Treponema hyodysenteriae from other intestinal spirochaetes. 50 6

Treponema hyodysenteriae was found to survive for periods of up to 48 days in dysenteric pig faeces stored at temperatures between 0 degree C and 10 degree C inclusive. Survival was reduced to seven days at 25 degree C and did not exceed 24 hours at 37 degree C. Dilution 1:10 with tapwater appeared to enhance survival to a maximum of 61 days at 5 degree C but further dilution reduced it. Drying and exposure to disinfectants rapidly eliminated T hyodysenteriae from dysenteric faeces. Phenolic and sodium hypochlorite disinfectants were most effective. The use of these findings in the formulation of control programmes for swine dysentery is discussed.
Vet Rec 1978 Jul 22
PMID:Factors affecting the survival of Treponema hyodysenteriae in dysenteric pig faeces. 68 4

Individual and epizootological observations on scouring in a large flock of three-to 10-week-old growing rabbits indicate that spread from animal to animal is not characteristic in outbreaks of rabbit dysentery. Although the disease occurs chiefly after weaning, precipitation of the symptoms seems to be unrelated to weaning stress. Intestinal flora studies on infected and control animals have shown that the bacteriological background of the condition is varied. Marked increase of coliforms over controls occurred in 70 per cent of the cases, coliforms and clostridia had both increased in 20 per cent, and clostridia only in 5 per cent. In the remaining 5 per cent the intestinal flora did not differ from normal, although death from rabbit dysentery was readily obvious. Microscopic examinations for coccidial oocysts of mucosal scrapings from different intestinal segments have shown that oocyst counts sufficient to give rise to clinical coccidiosis were only exceptionally present.
Vet Rec 1978 Oct 07
PMID:Rabbit dysentery: 1. Clinical, epizootological and bacteriological studies. 72 94

Control of rabbit dysentery in three-to 10-week-old growing-broiler rabbits was attempted by individual therapy of diseased animals and prophylactic flock treatment. Antibiotics selected on the basis of previous resistance tests failed on both therapeutic and preventive application, but a notable reduction of losses could be achieved by prophylactic medication with coccidiostatics. Clinically ill animals did not, however, respond to coccidiostatic therapy. Analysis of intestinal bacterium flora in the diseased animals and the good results of preventive coccidiostatic treatment suggests that the basic mechanism underlying rabbit dysentery is coccidial infection.
Vet Rec 1978 Oct 07
PMID:Rabbit dysentery: 2. Therapeutic experiments. 72 95

The diagnostic differentiation of rabbit mucoid enteritis from rabbit dysentery by age and post mortem findings is described. The condition termed as "rabbit dysentery" affects three- to 10-week-old growing rabbits and is essentially an acute coccidiosis, while "mucoid enteritis" develops in older rabbits as a sequel to constipation for six to eight days. The main differentiating feature of the two conditions, which have often been confused with one another owing to similarity of symptoms, is the characteristics dissimilarity of gross changes in the caecum.
Vet Rec 1978 Oct 07
PMID:Rabbit dysentery: 3. Diagnostic differentiation. 72 96

A postal survey was carried out by the Pig Veterinary Society to establish the opinions of its members on priorities for pig research: 153 members, 64 per cent of the total--returned analysable questionnaires. The survey shows that problems of highest priority for members are atrophic rhinitis, non-infectious infertility, neonatal enteritis, economics of disease, preventive medicine programmes and swine dysentery. The membership was classified by the nature of their work into five groups and the six subjects listed above cover the top three priorities of all groups. A classification of the papers listed in the Index of Current Research on Pigs XXII 1976 suggests that some of the six subjects are under researched.
Vet Rec 1976 Dec 04
PMID:Priorities for pig research. 99 96

Experimental swine dysentery was produced in groups of susceptible pigs by feeding pure cultures of two isolates of T hyodysenteriae. These infected groups of pigs were then used to assess the efficacy of ronidazole medication of the drinking water and of the feed in the treatment and prophylaxis of the experimental disease. Ronidazole was found to be effective in the treatment of swine dysentery and appeared to eliminate the causal agent, T hyodysenteriae, from treated affected pigs when given in the drinking water at 30 and 60 ppm for three days and in the feed at 120 ppm for four days. The inclusion of ronidazole in the feed for 14 days at 30, 60 and 90 ppm was found to suppress the development of the disease but 90 ppm was the only level found to prevent the development of infection.
Vet Rec 1976 Dec 04
PMID:Ronidazole in the treatment and prophylaxis of experimental swine dysentery. 99 97


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