Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ninety-six urine samples were collected by a sterile technique from 75 dogs affected with urinary tract disease (cystitis, urolithiasis, prostatitis, etc) involving bacteruria. The infecting organisms were isolated and tested against sensitivity discs (penicillin G, streptomycin, chloramphenicol, tetracycline, sulphamethoxazole/trimethaprin and Sulphatriad). The commonest isolate was Escherichia coli, which was generally sensitive to several agents, though in eight cases it was resistant to all drugs. Next in order were Streptococcus faecalis, Staphylococcus epidermidis and Proteus spp. A double infection was present in 11 cases. Further data give a breakdown for sex and the clinical diagnosis, neither of which was related to any particular organism.
Vet Rec 1977 Jul 23
PMID:Lower urinary tract pathogens in the dog and their sensitivity to chemotherapeutic agents. 33 57

Using the fluorescent antibody test, the presence of antibody-coated bacteria in 10 out of 17 urine sediment samples from cattle infected with Corynebacterium renale is described. These antibodies were mainly of the immunoglobulin class IgG, and to a lesser extent IgA. This finding is characteristic for infections of the upper urinary tract (pyelonephritis). In seven samples no antibody coating of the bacterial surface was detected. In these cases an infection of the lower urinary tract (cystitis) is suggested.
Vet Rec 1979 Sep 29
PMID:Antibody coated bacteria in urine sediment from cattle infected with Corynebacterium renale. 39 Aug 48

A case of pancreatitis with gastrointestinal ulceration and haemorrhage and necrotising cystitis in a five-and-a-half-year-old dachshund bitch which unexpectedly died six days after dorsolateral fenestration was performed for thoracolumbar degenerative disc disease is described.
Vet Rec 1985 Apr 13
PMID:Pancreatitis, gastrointestinal ulceration and haemorrhage and necrotising cystitis following the surgical treatment of degenerative disc disease in a dachshund. 387 44

Twenty-three cases of porcine cystitis and pyelonephritis were examined bacteriologically. Eubacterium suis was found in 21 cases. The isolation of large numbers of Escherichia coli in the upper urinary tract was associated with linear renal scarring. An unidentifiable streptococcus and Enterococcus faecalis were isolated from a case of purulent ureteritis, pyelitis and pyelonephritis. The bacterial flora from cases of cystitis and pyelonephritis was different from that isolated from sows with asymptomatic bacteriuria.
Vet Rec 1993 Jun 05
PMID:Bacterial flora of the urinary tract of pigs associated with cystitis and pyelonephritis. 833

The clinical findings, and urinary and morphological changes in the urinary bladder were investigated in 25 sows with a urinary tract infection. Eubacterium suis was isolated from 12 of the sows but not from the other 13. The clinical signs did not always correlate with the morphological changes. The only clinical sign indicating the beginning of cystitis appeared to be a significant bacteriuria. Other urinary changes occurred later when the inflammatory processes were more severe. In contrast with cystitis due to other bacteria, infection with E suis frequently resulted in a macrohaematuria and urinary pH values above 8.0. However, the light and electron microscopical findings in the bladder mucosa were similar in the sows with and without cystitis due to E suis. The transformation of goblet cells and the development of mucin cysts were probably due to the local bladder defence mechanisms. More severe lesions were observed with E suis infections, which resulted in changes in the ureterovesical junctions and in ascending renal infection and uraemia.
Vet Rec 1995 Aug 05
PMID:Clinical, and light and electron microscopical findings in sows with cystitis. 854 Feb 7

Artificial insemination is a valuable method for facilitating genetic exchange between captive colonies of koalas (Phascolarctos cinereus) and for the maintenance of genetically important remnant populations. However, to reduce potential disease transmission, their semen needs to be screened for venereal diseases caused by organisms such as Chlamydia species. Semen samples from 11 koalas, eight of them with clinical signs of cystitis, were examined for the presence of Chlamydia by an optimised PCR assay. Chlamydia was detected in semen from seven of the 11 animals.
Vet Rec 2002 Aug 03
PMID:Screening semen from koalas (Phascolarctos cinereus) for Chlamydia species by PCR. 1219 34

Mycoplasmas identified as Mycoplasma canis were isolated from nine dogs with clinical signs of urogenital disease in Norway over a period of 20 months. Some of the dogs had been treated unsuccessfully with antibiotics, and three were euthanased as a result of severe persistent disease. Seven of the dogs had a urinary tract infection, one had chronic purulent epididymitis and one had chronic prostatitis. Overt haematuria was frequently observed among the dogs with cystitis. M canis was isolated in pure culture from seven of the dogs and in mixed culture from the other two. In three cases the mycoplasma was cultivated only from urinary sediment, and it was typically obtained in smaller numbers than would be considered indicative of a urinary tract infection. In contrast with most mycoplasmas, the M canis isolated from all the dogs grew on ordinary blood agar plates used for routine bacteriological cultivation. Specific mycoplasma media were not used and the presence of other Mycoplasma or Ureaplasma species cannot be excluded.
Vet Rec 2003 Aug 23
PMID:Mycoplasma canis and urogenital disease in dogs in Norway. 1296 46

Five horses with sabulous cystitis were managed for up to three years. They were treated by emptying the bladder through a urinary catheter and saline lavage with cytoscopic guidance to remove residual sabulous material. The cystitis was treated with antimicrobial and anti-inflammatory medications, and bethanechol chloride was also administered. Frequent catheterisation and emptying of the bladder was an alternative to regular cystoscopic examination with saline lavage but it resulted in the development of a urethral stricture in one case. Four of the horses returned to work and one was retired owing to persistent incontinence.
Vet Rec 2008 Jun 14
PMID:Long-term management of sabulous cystitis in five horses. 1855 29

Sterile haemorrhagic cystitis (SHC) is a possible side effect of cyclophosphamide which can severely impact quality of life. Mesna and diuresis are effective in human medicine to prevent SHC. The aim of the present study was to compare the efficacy of mesna versus diuresis with furosemide in preventing SHC in dogs treated with cyclophosphamide within a multidrug chemotherapy induction protocol for malignant lymphoma. Medical records of dogs treated at the Clinic of Small Animal Medicine, Munich, between 1997 and 2009 were analysed retrospectively. Of the 131 dogs included, 33 received no prophylaxis (group 1), 43 received mesna (group 2), and 55 received furosemide (group 3). Age, gender, breed, bodyweight, body surface area, dose and application method of cyclophosphamide, and the method of SHC prophylaxis were compared between dogs with and without SHC. Six dogs (4.6 per cent) developed SHC. The incidence of SHC in groups 1, 2 and 3 was 4/33 (12.1 per cent), 1/43 (2.3 per cent), and 1/55 (1.8 per cent), respectively. Dogs receiving either mesna or furosemide were significantly less likely to develop SHC (P=0.03). Otherwise no significant differences were found. In conclusion, this study demonstrates the efficacy and the medical indication of mesna and furosemide for prevention of cyclophosphamide-induced SHC.
Vet Rec 2014 Mar 08
PMID:Mesna and furosemide for prevention of cyclophosphamide-induced sterile haemorrhagic cystitis in dogs--a retrospective study. 2446 93

The aim of this retrospective study was to document the prevalence of bacterial species in cats with significant bacteriuria and to compare their antimicrobial susceptibilities over five years. One hundred sixty-nine positive urine cultures from 150 cats were included. Fifty-five per cent showed clinical signs, while 40 per cent had subclinical bacteriuria. Escherichia coli, Staphylococcus species, Enterococcus species, Streptococcus species and Proteus mirabilis accounted for 50.5 per cent, 22.9 per cent, 15,1 per cent, 3.6 per cent and 2.6 per cent, respectively. Enterococcus species was significantly more common in cats with subclinical bacteriuria. Enterococcus species and Proteus mirabilis isolates were resistant to a significantly higher number of antimicrobials than other isolates. Applying the formula to select rational antimicrobial therapy, bacterial isolates were most likely to be susceptible to imipenem, nitrofurantoin, gentamicin and amoxicillin clavulanic acid. Over the study period, only minor differences were noted for the antimicrobial impact factors (IFs) between years and between cats with and without clinical signs. The cumulative IF increased significantly compared with the previous 10 years. Empirical treatment of bacterial cystitis should be avoided whenever possible and, if needed, based on the locally determined bacterial spectrum and antibiotic susceptibility.
Vet Rec 2018 07 07
PMID:Prevalence of feline urinary tract pathogens and antimicrobial resistance over five years. 2997 12


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