Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Since October 1982 three cases of cowpox infection of the cat have been presented at a veterinary practice. The disease began as a focal dermatitis on the face or paws which spread after several days to the rest of the body. Two weeks after appearing the pocks scabbed over and fell off leaving hairless skin. There were few systemic signs and therapy did not appear to influence the course of the disease. Diagnosis was confirmed by the demonstration of pox virions or inclusion bodies in skin biopsy or scab material using electron microscopy and by isolation of cowpox virus in chick embryos. High antibody titres to cowpox were observed in the sera of two cats.
Vet Rec 1985 Sep 07
PMID:Three cases of cowpox infection of domestic cats. 409 74

Three naturally occurring cases of cowpox virus infection in the domestic cat are described. Isolate L97 was identified as cowpox virus on the basis of morphology, serology and characteristic cytopathic effect in tissue culture and on the chorioallantoic membrane of embryonated eggs. All three cases showed multiple skin lesions, slight conjunctivitis or purulent ocular discharge but there were no respiratory signs. Two animals recovered, the third was put down as a stray. The disease was reproduced in experimental cats. Isolate L97 was inoculated into two cats intravenously and two cats by skin scarification. All four developed skin lesions at the site or sites of inoculation, and in one cat multiple lesions developed. The two intravenously inoculated animals also developed severe oedema of the neck and brisket around the site of inoculation into the jugular vein, and one cat died. Serological and pathological findings on both the natural and experimental infections are described. Serum neutralising antibody titres in both natural and experimental early convalescent cases were significantly enhanced by the addition of complement.
Vet Rec 1983 Feb 19
PMID:Natural and experimental pox virus infection in the domestic cat. 683 97

Pox virus infection of a domestic cat is reported. It was manifest clinically as a skin infection which resolved within two months. Histopathology and electron microscopy of the epidermis revealed inclusion bodies typical of pox virus infection. Serological examination of convalescent serum confirmed recent pox virus infection. Cow pox virus was considered as the most likely infectious agent in this case.
Vet Rec 1983 Feb 19
PMID:Pox virus infection of a domestic cat. 683 98

Several fox vaccination campaigns against rabies have been undertaken in Belgium by using a vaccinia-rabies recombinant virus distributed in baits in the field. However, foxes and other wild animals that may ingest the baits could be infected at the same time by another orthopoxvirus, such as cowpox virus, which circulates in wildlife. Recombination between the two viruses could therefore occur. A serological survey for antibodies to orthopoxvirus, and particularly to cowpox virus, was undertaken in foxes and in several other wild species. Antibodies were detected only in two rodent species, in 16 of 25 bank voles (64 per cent) and in two of 29 woodmice (7 per cent). The risk of virus recombination in wildlife can therefore be considered to be extremely low.
Vet Rec 1996 Mar 16
PMID:Serological survey for orthopoxvirus infection of wild mammals in areas where a recombinant rabies virus is used to vaccinate foxes. 873 5

The prevalence of antibodies to orthopoxvirus in 217 sera collected from domestic cats in the western part of Norway was 10.1 per cent as measured by a competitive ELISA. In one of the seropositive cats antibodies were also detected by an immunofluorescence assay. The average age of the cats sampled was 4.9 years, but the average age of the seropositive individuals was 7.3 years, higher than the average age of clinical cowpox virus cases in Britain (4.2 years), and in Germany (3.9 years). Antibodies against feline immunodeficiency virus (FIV) were detected in nine of 30 (30 per cent) of the seropositive cats, and in five of 30 (17 per cent) of the seronegative cats, which suggests that FIV infection may influence the susceptibility of domestic cats to orthopoxvirus, or vice versa. Orthopoxvirus infections, have recently been detected in rodent populations in several areas of Norway, and the infection may therefore be present in cats all over the country; cat owners and animal handlers should be aware of this (re)emerging zoonosis.
Vet Rec 1998 Jul 25
PMID:Antibodies to orthopoxvirus in domestic cats in Norway. 972 76