Gene/Protein Disease Symptom Drug Enzyme Compound
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 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A thoroughbred foal had a convulsive attack 12 hours after birth followed by further convulsions on the 10th, 11th and 12th days after birth. It was treated successfully by medication with primidone, feeding by stomach tube and careful nursing.
Vet Rec 1977 Jul 23
PMID:Recurrent convulsions in a thoroughbred foal: management and treatment. 40 67

An 18-week-old male German shepherd dog had a convulsion following the accidental ingestion of bromocyclen two hours previously. The dog then vomited and had a second convulsion. A pulse rate of 150 per minute and a respiratory rate of 54 per minute were recorded. The dog was treated with 2mg acepromazine and 0.6mg atropine administered intramuscularly (im) and repeated every four hours, 10ml of 20 per cent calcium borogluconate administered subcutaneously and 2ml penicillin and streptomycin im. Eighteen hours later, the respiratory rate was in excess of 60 per minute, and penicillin and streptomycin plus 2mg betamethasone were administered im. Only atropine was administered over the next 12 hours and then discontinued. Forty hours after the original convulsion, the respiratory rate had fallen to 30 per minute and the pulse rate to 84 per minute. A day later, the dog had fully recovered.
Vet Rec 1979 May 19
PMID:Bromocyclen poisoning in the dog. 47 58

A "ball and socket-like" junction between branches of the Sertoli cells and the developing spermatids is described. A cytoplasmic extension of the Sertoli cell fits into a pocket in the spermatid and has a constricted neck region. Frequently there are large multivesiculate bodies in the Sertoli cell extension and small vesicles frequently appear in the spermatid cytoplasm, in the area of the "ball and socket-like" junction. This suggests the possibility that there may be communication of materials between the two cells. The possible function of the junctions is discussed and it is concluded that they more likely have a role in nutrition than in coordination.
Anat Rec 1978 Jun
PMID:Spermiogenesis in Nautilus pompilius. II. Sertoli cell-spermatid junctional complexes. 66 21

On the basis of experimental data a model of induced mutagenesis is proposed that takes into account the repair of DNA damage by the rec-system. The peculiar feature of the rec-system is the cleavage and resynthesis of long sequences near the recognized DNA-damage. Up to 100--2000 nucleotides are replaced in one act. Therefore a definite probability exists of finding a damaged point on the second strand serving as template. It is believed that at this point no requirements of complementary exist and that a random substitution can take place. This is the origin of point mutation. From the model a general formula for the dose-response curve of mutagenesis is deduced which also takes into account the possibility of simultaneously initiated repair on both complementary strands of DNA. The latter leads to a lethal event when the points are situated priximally. This formula fits the observations in different cases studied, for instance, in case of transition from uvr+ to uvr- strains. The absence of repair mutagenesis in case of transforming DNA damage is readily explained by one-strand integration.
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PMID:[Mechanism and kinetics of repair mutagenesis]. 82 36

Basic multicellular unit (BMU)-based remodeling of lamellar bone causes bone turnover, net gains and losses of bone on some bone surfaces or "envelopes," and a remodeling space comprising bone temporarily absent due to evolving resorption spaces and incomplete refilling of them by new bone. Those features depend a) on how many new BMU arise annually, b) on how much bone each BMU has resorbed and c) formed upon its completion, and d) on how long the typical BMU takes to become completed. Because a, b, and c have limiting or maximal values in life that direct and/or indirect effects of mechanical usage of the skeleton can change, the theory presented here derives mechanical usage functions that express what fractions of those maxima a given mechanical usage history allows to happen. The theory predicts some changes in bone formation, resorption, balance, turnover, and remodeling space that depend on how remodeling responds to the vigor of a subject's mechanical usage. The theory can predict specific effects of specific mechanical challenges that experiments can test, and it fits abundant published evidence. As the kernel of a new approach to the problem it awaits critique and refinement by others. It plus the 3-way rule can redefine Wolff's law conceptually and also in mathematical and quantifiable form.
Anat Rec 1990 Apr
PMID:Skeletal structural adaptations to mechanical usage (SATMU): 2. Redefining Wolff's law: the remodeling problem. 218 96

A series of 1-alkylsulfonylaryl-1,4-benzodiazepine derivatives were synthesized and assayed for their pharmacological profile. All the compounds tested exhibited a competitive antagonism of 3H-diazepam binding in cerebellum, cerebrum and submaxillary gland. Compound II (rec. INN tolufazepam) had a Ki of 12.7 nM in cerebrum and 400 nM in the submaxillary gland. It was very potent in preventing convulsions elicited by pentylenetetrazol (ED50 p.o.: 16.5 and ED50 i.v.: 20 mg/kg). This anticonvulsant action was suppressed by previous administration of Ro 15-1788. Compound II was also active in inhibiting suppressive behaviour in the test of Vogel. This compound has a relative low hypnogenic activity as well as a low potency to produce motor incoordination. Our results show that tolufazepam has a potential clinical usefulness.
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PMID:Pharmacological activity of novel alkylsulfonylaryl-1-substituted-1,4-benzodiazepine derivatives. 290 26

The observed fit of bone mass to a healthy animal's typical mechanical usage indicates some mechanism or mechanisms monitor that usage and control the three longitudinal growth, bone modeling, and BMU-based remodeling activities that directly determine bone mass. That mechanism could be named a mechanostat. Accumulated evidence suggests it includes the bone itself, plus mechanisms that transform its mechanical usage into appropriate signals, plus other mechanisms that detect those signals and then direct the above three biologic activities. In vivo studies have shown that bone strains in or above the 1500-3000 microstrain range cause bone modelling to increase cortical bone mass, while strains below the 100-300 microstrain range release BMU-based remodeling which then removes existing cortical-endosteal and trabecular bone. That arrangement provides a dual system in which bone modeling would adapt bone mass to gross overloading, while BMU-based remodeling would adapt bone mass to gross underloading, and the above strain ranges would be the approximate "setpoints" of those responses. The anatomical distribution of those mechanical usage effects are well known. If circulating agents or disease changed the effective setpoints of those responses their bone mass effects should copy the anatomical distribution of the mechanical usage effects. That seems to be the case for many agents and diseases, and several examples are discussed, including postmenopausal osteoporosis, fluoride effects, bone loss in orbit, and osteogenesis imperfecta. The mechanostat proposal is a seminal idea which fits diverse evidence but it requires critique and experimental study.
Anat Rec 1987 Sep
PMID:Bone "mass" and the "mechanostat": a proposal. 368 55

Transmission of infection between animals is possible when using multidose syringes. The possibility of infection spreading can be reduced by using a telescopic device which fits the syringe barrel and is topped by a cap containing plastic foam impregnated with biocide. Under laboratory conditions, and continually contaminating the needle with various bacteria, infection could not be cultured in broth until after at least 25 injections and in most cases contamination did not occur after 50 injections. When culture was undertaken on solid media breakdowns occurred more frequently, possibly because the agar became lodged in the needle and shielded the bacteria from the biocide.
Vet Rec 1985 Feb 16
PMID:A practical method of reducing spread of disease by hypodermic needles. 399 60

Six circus lions (Panthera leo) showed neurological and gastrointestinal signs after consuming casualty broiler chickens. Signs included ataxia, hindlimb paralysis and recumbency. Neurological examination of two affected males showed paralysis of extraocular muscles, fixed dilated pupils and inability to swallow. Replacement fluids and antibiotics were given and Clostridium botulinum type C antitoxin was found in serum samples. Type C antitoxin was not then available and therapy was started in one lioness with guanidine hydrochloride. Convulsions were controlled by diazepam but this animal died. One of the two males was given type C antitoxin; both were given anabolic steroids. All the remaining animals made slow recoveries over varying periods; one lion was recumbent for 41 days. No lion developed respiratory paralysis; other animals which had consumed the chickens remained healthy. Aspects of the treatment of botulism in animals are discussed.
Vet Rec 1985 Jul 20
PMID:Diagnosis and treatment of botulism in lions. 404 82

Of 21 dogs from Sapporo, Hokkaido that had been recognised as having been bitten by ticks, 16 were seropositive to Borrelia burgdorferi by ELISA. Thirteen of the seropositive dogs showed signs such as fever, astasia, convulsions, anorexia, fatigue, abnormal gait, nervous signs, diarrhoea, corneal opacity and conjunctivitis. These signs subsided as a result of antibiotic treatment within five days. The plasma concentrations of creatinine in the 21 dogs were higher than in control dogs. Seven ticks that were removed from seven of the dogs were Ixodes persulcatus, and B burgdorferi was isolated from the midgut of two of the ticks.
Vet Rec 1994 Apr 09
PMID:Canine Lyme disease: clinical and serological evaluations in 21 dogs in Japan. 800 99


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