Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirty brucellosis free calves with zero titres to the serum agglutination test (SAT), complement fixation test (CFT) and antiglobulin test (ABGT) were vaccinated with strain 19 at ages from seven hours to 198 days. Calves 75 days of age and older responded with normal serological patterns, developing high titres to all three tests. At 45 days and younger most calves responded with much reduced titres, some were negative to the SAT and CFT but all develped titres to the ABGT. Two of the younger group were subjected to an anamnestic test at about a year old and gave a positive response, indicating that the calf may be effectively primed with S19 as early as the first day of life. Three of the group were colostrumdeprived yet the patterns of their responses were similar to those of the colostrum-fed calves. Seventy-four zero titres calves were vaccinated with killed 45/20 adjuvant vaccine at ages from 60 to 320 days. Up to 200 days of age only seven of 33 calves gave positive response. From 200 to 280 days 18 of 29 responded and from 280 days of age all calves a positive response. The late development of competence to respond to this adjuvant vaccine is somewhat unusual and is discussed. It is suggested that the rough strain 45/20 may be a very weak antigen in cattle.
Vet Rec 1977 Oct 01
PMID:The effect of immaturity of the calf on immunological responses to strain 19 and killed 45/20 adjuvant vaccines. 41 Dec 31

A complement fixation test (CFT) based on that used for brucellosis (Brinley Morgan and others 1971) has been developed for use on the sera of horses exposed to the contagious equine metritis (CEM) organism. None of 50 single samples from horses thought to be unexposed to the CEM organism was positive to the test, although five showed inconclusive reactions. Samples were examined from 41 mares either proved to be infected or from an infected stud. Of these 21 were positive, 11 were inconclusive and nine were negative. The relationship of the CFT to reactions in the other tests used in this condition is discussed--the serum agglutination test (SAT) and antiglobulin test (AGT) (Benson and others 1978). Complement fixing antibodies appear to remain for a longer period in the infected animal, and are therefore more likely to be of use in the diagnosis of the chronic carrier state.
Vet Rec 1978 Sep 23
PMID:A complement fixation test for antibody to the contagious equine metritis organism. 71 83

Brucella complement fixing antibodies may be titrated independently in adult vaccinated (strain 45/20) and in naturally infected cattle by serological tests utilizing a specially prepared antigen. Serum samples are subjected to the standard complement fixation test for the diagnosis of brucellosis (MacKinnon 1963) and subsequently retested by the same method but with a saline extract antigen prepared from strain 45/20 Brucella abortus. The results obtained in the two tests are compared in five specific categories of brucella reactors. An evaluation and discussion of the test method, on the basis of the results obtained, indicates that informed diagnoses can be made in parallel with a continuous adult vaccination programme.
Vet Rec 1976 Mar 13
PMID:A complement fixation method for quantitative differentiation of reactions to 45/20 vaccine and Brucella infection. 81 37

Dysfunction of the cellular immune mechanism was found in 23 patients with persistent symptoms of brucellosis of more than one year's duration when skin tested for delayed hypersensitivity to dinitrochlorobenzene (DNCB). Eighteen patients had low normal or depressed E rosetting capacity of their lymphocytes. Anti-anergic treatment with levamisole 150 mg daily for one month and for two consecutive days each week for six months produced an exacerbation of symptoms after one to four weeks followed by complete relief from symptoms in 15 patients and partial relief in four. Vitamin A was used to potentiate the effect of levamisole in seven patients.
Vet Rec 1977 Jul 09
PMID:Chronic human brucellosis and anti-anergic treatment with levamisole. 90 16

The effect of brucellosis on semen quality in rams was studied by means of artificially infecting five rams with a strain of Brucella ovis isolated in Kenya. Infection resulted in reduced semen quality including reduced total sperm output, poor motility and a high percentage of morphological abnormalities. Variation in semen quality both between and within rams appeared to be related to progress of the disease in the epididymis as well as to the distribution and severity of lesions in the reproductive tract.
Vet Rec 1976 Sep 18
PMID:Characteristics of semen changes during Brucella ovis infection in rams. 98 55

The coming into effect on July 14 of the Zoonoses Order 1975, marks a new and important step in veterinary public health. The Order makes available powers to investigate and control Salmonella and Brucella infections in animals and Salmonella infections in birds which present a threat to human health. Any Salmonella and Brucella infection becomes reportable in certaain species when organisms have been isolated by laboratory test. Veterinary surgeons and livestock owners may be involved in this obligatory procedure. The statutory powers to investigate incidents and apply restrictions on the movement of animals, birds and their products are not limited to reportable species: they cover a much wider range of animals and birds. They will be held in reserve and used only when necessary because of a hazard to public health; the use of restrictions will be limited to cases involving a very serious threat to man. The information collected from reports and investigations will add considerably to the epidemiological knowledge of these infections and so allow improved methods of control to be developed. Some of these measures already in operation are described, together with others possible for the future.
Vet Rec 1975 Jul 12
PMID:The Zoonoses Order, 1975. 114 93

Of 1140 vaginal mucus agglutination tests (VMAT) on specimens obtained in 1971-72 from 663 dairy cows in seven herds infected with brucellosis, 97 were positive. When the VMAT was positive one or more serological tests were also positive. Of the 97 corresponding serum agglutination tests 80 sera had titres of more than 533 international units. Only 69.8 per cent of VMAT from serologically positive cows were positive. No evidence was found of non-specific agglutinins in vaginal mucus and positive VMAT reactions appeared to be specific for field infection. Three cows showed evidence of local agglutinins in the vagina. Hence herd testing by VMAT has no advantage over tests of blood serum but the test could be an aid in establishing whether individual cattle are infected.
Vet Rec 1986 May 03
PMID:The vaginal mucus agglutination test in the diagnosis of bovine brucellosis. 308 49

Twenty-two buffalo bulls suffering from three different types of infertility were slaughtered and used for this study. Except for the reproductive system, no signs of localised or generalised disease were observed. Microbiological investigations were negative for brucellosis, vibriosis, mycoplasma and other non-specific microorganisms. Nine bulls with type 1 infertility had low bodyweights and underdevelopment of testes, accessory sex glands and endocrine glands. This picture suggests a total dysfunction of the pituitary-growth-gonadal axis. One bull of this type also showed bilateral epididymitis. Four out of 11 bulls with type 2 infertility had low bodyweights and most suffered from underdevelopment of testes, accessory sex glands and endocrine glands. Six bulls of this type had lesions of either epididymitis or orchitis or both. Two of these animals showed adhesions of periorchitis. One also showed seminal vesiculitis. In two bulls with type 3 infertility, bodyweights, reproductive organs and endocrine glands were normal. In later life, they yielded poor quality semen. Semen samples collected a few months before slaughter from nine bulls with type 2 and type 3 infertility were of poor quality and had higher percentages of abnormal spermatozoa in most cases.
Vet Rec 1985 Aug 03
PMID:Post mortem studies on infertile buffalo bulls: anatomical and microbiological findings. 404 94

Twenty-four cases of stifle (femoro-tibial joint) arthritis, in Friesian heifers that had failed their first blood test for brucellosis, were examined pathologically and by serological and cultural tests for brucella. The arthritis was confined to the stifle and was non-purulent. The cases showed several other similar features, including evidence of trauma, erosions of articular surfaces, synovial proliferations and granulomata containing germinal centres and plasma cells. The synovial fluid was turbid, discoloured and usually increased in volume, with high antibody titres to brucella. Cultures were invariably negative for brucella, but examinations of cryostat sections stained by fluorescent antibody against B abortus were positive in five out of six cases examined some showing particles with a morphology resembling that of brucella.
Vet Rec 1980 Feb 02
PMID:An association between arthritis and persistent serological reactions to Brucella abortus in cattle from apparently brucellosis-free herds. 676 7

Allergens prepared from a smooth strain of Brucella abortus (S99) were used in an intradermal test for the diagnosis of brucellosis in cattle. The development and testing of the allergen from the initial less purified stages is described. The removal of serological activity noted in some of the earlier preparations can be related to the elimination of molecules of high molecular weight. The final allergen is of a high order of sensitivity and specificity and does not cause production of complement fixing or agglutinating antibodies. Intradermal testing with such an allergen could be a most useful addition to present serological procedures as it could be carried out at the same time as tuberculin testing. As a routine surveillance test, particularly in low prevalence areas, it would eliminate the necessity for extensive blood sampling and in many cases detect the infected herd before serological tests would have become positive.
Vet Rec 1980 Oct 18
PMID:Immunological characteristics in cattle of allergens derived from smooth Brucella abortus S99. 678 Nov 27


1 2 3 4 Next >>