Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pigs were vaccinated by scarification or intramuscular injection with a swinepox virus-Aujeszky's disease (pseudorabies) recombinant (rSPV-AD) constructed by inserting the linked Aujeszky's disease virus genes coding for glycoproteins gp50 and gp63, attached to a vaccinia virus p7.5 promoter, into the thymidine kinase gene of swinepox virus. By 21 days after vaccination, 90 and 100 per cent of the animals vaccinated by scarification or intramuscular injection, respectively, had developed serum neutralising antibodies to Aujeszky's disease virus. Upon challenge with virulent virus, significantly fewer vaccinated pigs developed clinical Aujeszky's disease, nasal shedding of challenge virus was markedly reduced, and the vaccinated groups of pigs maintained or gained weight during the week after challenge whereas the unvaccinated control group lost weight. No transmission of rSPV-AD to in-contact controls was detected during the three weeks before challenge. In a second experiment, serum neutralising antibodies to Aujeszky's disease virus persisted for 150 days after the pigs were vaccinated with rSPV-AD by scarification or intramuscular injection and all the pigs showed an anamnestic response when they were revaccinated.
Vet Rec 1994 Jan 01
PMID:Evaluation of swinepox virus as a vaccine vector in pigs using an Aujeszky's disease (pseudorabies) virus gene insert coding for glycoproteins gp50 and gp63. 812 61

The data provided by the sequencing of the human genome showed that retroviral-like elements constituted approximately 8 % of the euchromatin. The origin of these elements, their propagation leading to an organization in families, their genetic structure and the identification of the fonctional domains of the components of these elements are described. Placenta is used as a model to illustrate the physiological involvement of HERVs. Transcriptional regulatory element (LTR) functions and the putative implication of retroviral proteins in resistance to infection, immunosuppression, and cellular differentiation are clarified. The data implicating the envelope encoded by the ERVWE1 locus of the HERV-W family in the fusion process, leading to syncytiotrophoblast formation, is analysed. The putative pathological effect of HERVs is illustrated by the expression of the HERV-K superfamily in cancer. More precisely, the association between the Rec regulatory protein encoded by HERV-K(HML-2) and testicular tumorigenesis is developed. Whether HERVs are triggers or markers in other physiopathological contexts is discussed. To conclude, the dual benefit-hazard underlying the acquisition/propagation of HERVs is examined with respect to species evolution, considering the multicopy trait of HERV families and the mainly multi-factorial aspect of autoimmune diseases and cancers.
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PMID:[Retroviral inheritance in man]. 1596 47