Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cyclic AMP and cyclic GMP, considered to be cell proliferation regulators, have been reported to fluctuate in proliferating fibroblasts in vitro. The objectives of this experiment were to study the localization, distribution and staining patterns of these cyclic nucleotides in mechanically-stressed, proliferating periodontal fibroblasts in vivo. Cat canines were tipped by force applications for 0 to 48 hours and serial sagittal sections of fresh frozen, unfixed, undecalcified jaws were processed immuno-histochemically for the localization of cAMP and cGMP. Periodontal tension sites were studied microscopically. Fibroblastic staining for cAMP, which was localized mainly in the cell periphery, did not change appreciably as a result of tension. However, staining intensity increased one hour after the application of force, decreased after 6 hours and increased again at 24 hours. Staining for cGMP, initially covering the entire cell area, was concentrated over nuclei three hours after onset of tension, and diffused over cell periphery and cytoplasm thereafter. Intensity of staining for cGMP was maximal at 3 hours and low at 12 and 48 hours. These results demonstrate that stress-induced fibroblastic responses in vivo involve alterations in staining intensity for both cyclic nucleotides which may correspond with fluctuations of these regulators, reported to occur in vitro in various stages of the mitotic cycle. Moreover, this technique enables the identification of the involved cells in a stimulated, non-synchronized cell population.
Anat Rec 1978 Nov
PMID:Immuno-histochemical localization of cyclic nucleotides in the periodontium: mechanically-stressed cells in vivo. 8 16

Previous experiments indicate that bone cells respond to external stimuli with fluctuations of cyclic nucleotide levels. The objective of this experiment was to study the response of alveolar bone to the application of tensile forces through an examination of the osteoblastic staining pattern for cAMP and cGMP. Cat canines were tipped by 80-g force for 0 to 48 hours. Fresh frozen, unfixed, undecalcified jaws were sectioned sagittally and stained immuno-histochemically for cAMP and cGMP. In tension sites, osteoblastic staining intensity for cAMP decreased gradually from one to three hours, and then increased by 24 hours. Intense staining for cGMP, visible in osteoblasts of all treated cats, peaked after three hours of treatment and then again at 24 hours. Generally, groups of cGMP-stained osteoblasts were found adjacent to unstained osteoblasts. The observed fluctuations in the osteoblasts staining pattern for cAMP and cGMP indicates involvement of these substances in the early response of osteoblasts to mechanical stimuli in vivo.
Anat Rec 1978 Nov
PMID:Immuno-histochemical localization of cyclic nucleotides in mineralized tissues: mechanically-stressed osteoblasts in vivo. 8 17

The photochemical stability of the anomalous nucleic acid base 5-azacytidine (z5Cyd) on irradiation at 254 nm is by about one order of magnitude less than that of cytidine (Cyd). Contrary to the photochemical behaviour, incorporation of z5Cyd into the nucleic acids of E. coli strains SR 20 (uvr+ rec+), SR 74 (uvr+ rec-) and SR 22 (uvr- rec+) produced a higher resistance to UV light. Only the SR 73 (uvr- rec-) strain was shown to have an increased UV sensitivity. This latter finding is in accord with the photochemical properties of z5Cyd. The results led to the conclusion that excision and recombination repair processes contribute to the observable protective effect. The fact that inhibition of excission repair by caffeine or proflavine of the mutant uvr+ rec- changes protection into sensitization supports this idea.
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PMID:Photochemistry and photobiology of 5-azacytidine: effect of repair on photostabilization of Escherichia coli. 8 41

The extracellular space of mouse ovarian follicles and stroma contained horseradish peroxidase (HRP) reaction product one minute after intravenous injection of the tracer. In addition to pinocytotic uptake of the tracer, non-vesicular staining with HRP reaction product, heretofore unrecognized, was noted in a variety of ovarian cell-types. This diffuse staining was correlated with changes in cellular morphology suggestive of degeneration. These findings are discussed in relation to the composition of cell populations comprising follicles and ovarian stroma and alterations in cell function.
Anat Rec 1979 Mar
PMID:Differences in mouse ovarian cells as distinguished by horseradish peroxidase labelling. 8 20


Vet Rec 1979 Jan 27
PMID:Staining of mast cell granules by the Ziehl-Neelsen method and differential diagnosis of malignant dermal tumours in the dog. 8 28

Fetal specific serum proteins of the Indian buffalo were investigated using rabbit antibuffalo fetal serum, absorbed with lyophilised adult buffalo serum, and subjected to gel diffusion and immunoelectrophoretic analysis. AFP was found to be the major fetal specific serum protein of the Indian buffalo. A close antigenic relationship between the fetal specific serum proteins of the buffalo, sheep and goat and a distant relationship between these proteins of ruminants and man was found by immunological cross reaction studies.
Vet Rec 1979 Feb 24
PMID:Fetal specific serum proteins of the Indian buffalo. 8 87


Vet Rec 1979 Feb 24
PMID:Rapeseed meal goitrogens and egg taint. 8 88

The antibacterial activity of three udder creams and two ointments was assayed using three different methods. Seven different bacterial genera were used as test organisms providing a total of 17 strains. Only a single strain of corynebacterium was inhibited by all the preparations. Certain strains of staphylococci and streptococci were inhibited by four of the preparations. The gram-negative organisms showed greatest resistance to the antibacterial agents tested. The in vitro assays showed only one of the five preparations to have even slight bactericidal activity. These preparations when tested on the teats of dry and lactating cows showed similar results to the in vitro experiments.
Vet Rec 1979 Mar 24
PMID:A comparison of the antibacterial properties of some udder creams and ointments. 8 50


Vet Rec 1979 Jun 23
PMID:The efficacy of a topical ear preparation against Otodectes cynotis infection in dogs and cats. 8 51


Vet Rec 1979 Jun 02
PMID:Use of delmadinone acetate. 9 Apr 22


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