Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Milk fever is a disease of increasing importance. In dairy herds its incidence has doubled since 1950; today about 8 per cent of parturitions in Swedish dairy cattle are complicated by milk fever. At the same time, the clinical picture has changed and the effectiveness of calcium therapy has been markedly reduced. Thirty to 40 per cent of cows with milk fever need more than one treatment. These trends are obvious in Sweden and Norway and have been reported from many other parts of the world. However, there are also geographical and breed differences so that these figures might not be applicable under British conditions.
Vet Rec 1978 Feb 25
PMID:Milk fever prevention. 2 7

Guinea pig epididymal sperm, incubated for ATPases at pH 7.0 or pH 9.0, localize reaction product on both the periacrosomal segment of the plasmalemma and the outer acrosome membrane. In other species, e.g., rabbit, Ca++-ATPase is identified with the outer acrosome membrane. It may transport Ca++ into the acrosome for activation of enzymes released during the acrosome reaction. The neutral ATPase is demonstrable on the periacrosomal plasmalemma and possibly modifies Ca++ concentration in the fluid around the acrosome. In guinea pig sperm, Ca++-ATPase is sensitive to centrifugation or washing of sperm which indicates that the ductal fluid has unusual properties for preservation of the acrosome. Inhibition of the enzyme by these treatments suggests that conditions on the plasmalemmal surface affect the acrosome membrane. Inability to separate reaction product on the plasmalemma from that on the acrosome membrane may be due to migration of reaction product across the periacrosomal space. However, the ATPases are elicited in the guinea pig under the same conditions as in other species. The pH 9.0 enzyme requires Ca++ while the enzyme at pH 7.0 has no ion specificities. Demonstration of these enzymes indicates that mechanisms of acrosome activation, similar to those in other sperm, are relevant to the guinea pig.
Anat Rec 1978 May
PMID:Identification of phosphates on the membranes of guinea pig sperm. 2 98


Vet Rec 1978 Aug 26
PMID:BVA congress 1978 Lancaster, September 4--8. Summaries of scientific papers. 2 74


Anat Rec 1979 Jan
PMID:Southern Society of Anatomists. Seventeenth annual meeting. October 19--21, 1978. Abstracts. 3

It was established that a thermophilic system for the treatment of pig slurry at 55 degrees C rapidly killed the free living stages of three common pig parasites. This treatment could be beneficially incorporated in any pig slurry recycling process, whether to land or to animals.
Vet Rec 1978 Oct 21
PMID:The destruction of pig helminth ova and larvae in a slurry treatment process. 3 82


Anat Rec 1979 Mar
PMID:American Association of Anatomists. Ninety second session. University of Miami School of Medicine. April 2, 3, 4, 5, 1979. Abstracts. 3 38

The effects on bruising and muscle pH of mixing cows and steers at loading, and 96 hours before loading, for transport to slaughter were examined. A second experiment investigated the effect on bruising of mixing two strange groups of steers at loading, 24 and 96 hours before loading. All cattle were hornless Bos indicus crossbreds from the same property in north Queensland. The bruise score, bruise trim weight and muscle pH of mixed cows and steers did not differ significantly from that of those transported separately. Mixing of two strange groups of steers did not significantly affect bruising. Time of mixing had no noteworthy effect on bruising. Cows bruised significantly (P less than 0.01) more than steers. These results have important implications for low cost beef management.
Vet Rec 1979 Jan 27
PMID:Bruising and muscle pH with mixing groups of cattle pre-transport. 3 19


Vet Rec 1979 Feb 03
PMID:The biochemistry, haematology, nutrition and racing performance of two-year-old thoroughbreds throughout their training and racing season. 3 33


Anat Rec 1979 Aug
PMID:Midwest Association of Anatomists. Thirty-sixth annual meeting. October 6-8, 1978. Downtown Holiday Inn, Dayton, Ohio. Abstracts. 3 81

Mutagenic, DNA-damaging, and in vivo alteration of DNA have been demonstrated for 1,2-dimethylhydrazine (DMH), a potent inducer of adenocarcinomas of the large intestine and colon of rats. These activities are pH-dependent, with 6.5 giving optimum response. There was no requirement for metabolic activation with rat-liver S9 mix when the appropriate Bacillus subtilis mutant strains were used. The Rec- strains recA8 and mc-1 were greater than 300-fold more sensitive to the DNA-damaging activity of DMH than was their isogenic wild-type parent. The DNA isolated from DMH-treated mc-1 had altered spectroscopic characteristics, and gave a greatly reduced transformation efficiency. Treatment of B. subtilis strain TKJ6321 with DMH at pH 6.5 induced His+, Met+ mutations in substantial numbers at low concentrations of this chemical. The use of B. subtilis mutants in these studies has therefore made it possible to demonstrate mutagenic and DNA-damaging activity in bacteria for this potent carcinogenic chemical.
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PMID:DNA-damaging and mutagenic effects of 1,2-dimethylhydrazine on Bacillus subtilis repair-deficient mutants. 4 Jan 24


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