Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UIJ5 (Rec)
 58,342 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A male miniature rough-haired dachshund, presented with episodic haematuria, was found to be a female pseudohermaphrodite. A littermate also had an abnormality of the urogenital tract and their dam had received a progesterone implant during pregnancy. Chromosome analysis of the intersex revealed XX/XY mosaicism in certain tissues.
Vet Rec 1979 Sep 08
PMID:Phenotypic intersex (female pseudohermaphroditism) in a dachshund dog. 55 19

A case of pancreatitis with gastrointestinal ulceration and haemorrhage and necrotising cystitis in a five-and-a-half-year-old dachshund bitch which unexpectedly died six days after dorsolateral fenestration was performed for thoracolumbar degenerative disc disease is described.
Vet Rec 1985 Apr 13
PMID:Pancreatitis, gastrointestinal ulceration and haemorrhage and necrotising cystitis following the surgical treatment of degenerative disc disease in a dachshund. 387 44

Hypersialism as an apparently primary condition is recorded in a young miniature long-haired dachshund. The condition was unilateral and cure was effected by ligation of the parotid salivary duct.
Vet Rec 1980 Dec 13
PMID:Unilateral parotid hypersialism in a dachshund. 746 9

A six-year-old female dachshund was examined because of intermittent lameness in its left pelvic limb and periodic back pain. Myelography, epidurography and computed tomography (CT) revealed a dorsal displacement of the dural sac in the lumbosacral region caused by a soft tissue mass which had the specific density of fat. The mass was removed via a dorsal laminectomy in the lumbosacral area and a histological examination confirmed that it was adipose tissue. The clinical signs resolved after the surgery and a follow-up CT five months later showed no evidence of compression of the dural sac. The diagnosis of epidural lipomatosis in this dog was based on the clinical findings, the results of diagnostic imaging, and the surgical and histological findings, all of which revealed many similarities with epidural lipomatosis in man.
Vet Rec 1996 May 18
PMID:Epidural lipomatosis in a six-year-old dachshund. 873 2

Calculi were located in the kidneys, the ureters and the bladder of a two-year-old male dachshund. The yellow-greenish calculi developed as a result of impaired transformation of xanthine to uric acid resulting in an increased concentration of xanthine in the urine. The cause of the impaired catabolism of xanthine was probably a disorder of the xanthine oxidase enzyme, which catalyses the transformation of xanthine to uric acid.
Vet Rec 1998 Oct 10
PMID:Xanthine urolithiasis in a dachshund. 980 92

A case-control study of 953 dogs with pyometra and 10,660 unmatched control dogs was used to investigate the relationships between age, parity, hormonal therapy and breed, and pyometra in Finnish dogs. Cases were reported in animals between nine months and 18 years of age, with a median age at diagnosis of nine years. Nulliparous bitches had a moderately higher risk of developing pyometra than primiparous and multiparous animals (adjusted odds ratio point estimate, 6.63). The administration of oestrogen increased the risk of pyometra in bitches up to four years of age (odds ratio point estimate > 6). No significant risk-enhancing effect of progestin treatment was detected and it is unlikely that such a risk, if present, is high (likelihood of the odds ratio exceeding 2 < 0.18). Seventeen breeds had an increased risk, and the wire-haired dachshund and mongrels had a decreased risk of developing the condition.
Vet Rec 1998 Oct 31
PMID:Associations between age, parity, hormonal therapy and breed, and pyometra in Finnish dogs. 983

A four-year-old wire-haired dachshund developed progressive neurological signs of ataxia, intention tremor and finally dysuria. Two years later, histopathology showed that neurons throughout the brain and spinal cord were distended with lipopigment which was also present in macrophages. Ultrastructurally, the pigment in the neurons occurred predominantly as electron-dense membranous whorls and stacks. There were a few vacuolated macrophages in the meninges. Hepatocytes were highly vacuolated and electron microscopy suggested that they were empty membrane-bound vesicles. The disease was diagnosed as mucopolysaccharidosis IIIA because of its similarity to other biochemically confirmed cases in the same breed and in a New Zealand huntaway dog. Additional lesions included calcium oxalate uroliths, severe secondary calcification of tissues including the brain and storage deposits in some neurons, and lesions which may have been associated with high levels of the substrate, heparan sulphate.
Vet Rec 2001 May 05
PMID:Histological diagnosis of mucopolysaccharidosis IIIA in a wire-haired dachshund. 1137 Aug 81

Osteogenesis imperfecta (OI) is a genetic disorder causing defects in the development of collagen type I. Clinical signs of affected dachshunds include multiple fractures of bones, joint hyperlaxity and dentinogenesis imperfecta. Recently, a recessive mutation in the SERPINH1 gene was detected in dachshunds and enabled the development of a DNA test to identify dachshunds carrying the mutation. The purpose of the present study was to analyse the dachshund breeding population for the frequency of the SERPINH1 mutation among the nine different breed varieties in dachshunds, birth years and countries of origin. We genotyped the OI-associated SERPINH1 mutation in 1352 dachshunds from 12 different European countries including all nine varieties. Genotyping was done using a restriction fragment length polymorphism validated by DNA sequence analysis. The overall frequency of OI carriers was 12.9 per cent. Across all different size varieties, the SERPINH1 mutation was over-represented in wire-haired dachshunds with 17.3 per cent OI carriers. Among the different countries, the proportion of OI carriers was highest in Germany with 20.4 per cent. The test is useful for dachshund breeders to prevent the occurrence of OI-affected dogs and as a diagnostic tool for veterinarians.
Vet Rec 2013 Apr 06
PMID:Population screening for the mutation associated with osteogenesis imperfecta in dachshunds. 2352 18

The clinical, ultrasonographic and histopathological features of a pancreatic multihormonal islet cell tumour are described in a 12-year-old dachshund with cutaneous lesions suggestive of metabolic epidermal necrosis. This condition was suspected because of the compatible cutaneous signs, a high plasma glucagon concentration and the detection of a well defined pancreatic mass by ultrasonography. The diagnosis was confirmed postmortem and by histology.
Vet Rec 1999 Dec 04
PMID:Ultrasonographic detection of a pancreatic glucagon-secreting multihormonal islet cell tumour in a dachshund with metabolic epidermal necrosis. 2570 70