Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q9UID3 (FFR)
 233 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Multivessel obstructive coronary artery disease is observed in about half of the STEMI patients undergoing primary PCI. Optimal management of non-culprit lesions in these settings continues to be a matter of debate and no consensus has been reached. Lack of robust scientific data led to significant heterogeneity in practice among different centres and countries. In general, three approaches have been defined in haemodynamically stable patients: an aggressive approach with non-culprit PCI during the index procedure, an intermediate approach with non-culprit PCI or CABG as a staged procedure during the index hospital stay or within 30 days, and a conservative approach with non-culprit PCI/CABG only in case of refractory symptoms or objective detection of ischaemia. Based on available data and subsequent post hoc pooled analysis, an intermediate approach has been considered as an accepted option and often adopted. Conversely, the recent PRAMI study results (Preventive Angioplasty in Acute Myocardial Infarction) suggested that an aggressive approach (including non-culprit PCI during the index procedure) provided better clinical outcome than the conservative "culprit only" approach. It is, however, as yet unknown if the aggressive approach used in the PRAMI study is also better than the traditionally advocated intermediate approach with angiographically or FFR-driven staged non-culprit revascularisation. The purpose of this review is to discuss the available evidence and integrate it into daily clinical decision making.
...
PMID:Multivessel PCI in STEMI: ready to be the recommended strategy? 2525 34

Ischemic heart disease is a dynamic process of atherosclerosis of the coronary arteries or functional alterations of coronary circulation that can be modified by lifestyle, pharmacological therapies, and revascularization. Such treatment may result in disease stabilization or regression. New terminology describes clinical presentations of Ischemic heart disease categorized as either acute coronary syndrome or chronic coronary syndrome. The reduction in prevalence of obstructive coronary artery disease in a symptomatic population causes a lower pretest probability and clinical likelihood of disease, influencing the diagnostic work-up. Noninvasive functional or anatomic imaging for myocardial ischemia is recommended as the initial test to diagnose coronary artery disease in symptomatic patients, where obstructive disease cannot be excluded by clinical assessment alone. Coronary computed tomography (CT) angiography has advanced and is first line in suitable patients, due to high rule-out power and further qualification of the diagnosis by functional assessment using noninvasive nuclear or magnetic resonance technology or CT-based fractional flow reserve (FFR-CT). Optimal medical treatment remains paramount, while FFR-guided myocardial revascularization in patients that are not responsive to antianginal treatment provides further symptom relieve as well as prognostic impact on prevention of spontaneous myocardial infarction.
 ...
PMID:Ischemic Heart Disease: An Update. 3228 6