Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UID3 (FFR)
 233 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Multivessel obstructive coronary artery disease is observed in about half of the STEMI patients undergoing primary PCI. Optimal management of non-culprit lesions in these settings continues to be a matter of debate and no consensus has been reached. Lack of robust scientific data led to significant heterogeneity in practice among different centres and countries. In general, three approaches have been defined in haemodynamically stable patients: an aggressive approach with non-culprit PCI during the index procedure, an intermediate approach with non-culprit PCI or CABG as a staged procedure during the index hospital stay or within 30 days, and a conservative approach with non-culprit PCI/CABG only in case of refractory symptoms or objective detection of ischaemia. Based on available data and subsequent post hoc pooled analysis, an intermediate approach has been considered as an accepted option and often adopted. Conversely, the recent PRAMI study results (Preventive Angioplasty in Acute Myocardial Infarction) suggested that an aggressive approach (including non-culprit PCI during the index procedure) provided better clinical outcome than the conservative "culprit only" approach. It is, however, as yet unknown if the aggressive approach used in the PRAMI study is also better than the traditionally advocated intermediate approach with angiographically or FFR-driven staged non-culprit revascularisation. The purpose of this review is to discuss the available evidence and integrate it into daily clinical decision making.
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PMID:Multivessel PCI in STEMI: ready to be the recommended strategy? 2525 34

In a ranking of the gross domestic product per capita in 2015, Belgium ranked 19th in the world according to the International Monetary Fun1d and the World Bank. It has a Human Development Index of 0.890, in which it is preceded by only 20 other countries in the world. This is, at least in part, due to a well-developed social security system on which all citizens can rely. Over the last 5-10 years, however, this system has come under increasing pressure. This has resulted in insufficient, incomplete and late reimbursement of all technologies that were introduced over the last ten years in the cathlab: intracoronary imaging techniques are not reimbursed at all, and FFR only to a vastly insufficient degree. For several structural heart interventions, a system of limited and incomplete reimbursement has recently been set up, with a requirement to organise these procedures within the frames of hospital networks. Numbers of PCIs have risen by 15% over the last four years, coinciding with an increase in the number of cathlabs by 50%, aiming at better access to primary PCI for STEMI patients. This has also resulted in a decrease in the average procedure volume per centre. Two thirds of PCIs are performed via the radial access. DES penetration has increased to 74%, approaching 100% in some centres, while the uptake of BRS has been very limited so far.
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PMID:Belgium: coronary and structural heart interventions from 2010 to 2015. 2850 23