Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q9UE34 (fibrinogen)
 30,244 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Eluates of 13 malignant and 17 normal tissues were prepared at 56 degrees C using the continuous flow technique. Albumin was detected in all the eluates. IgG, IgA, C3 or haptoglobin were detected in most of the malignant and some of the normal tissues. Carcinoembryonic antigen, beta 2-microglobulin, alpha 1-antitrypsin or alpha 1-antichymotrypsin were detected in some of the eluates of the malignant tissues only. IgM, IgD, C1q, C4, Cl-INH, alpha 1-macroglobulin, beta 2-lipoprotein, fibrinogen and alpha 1-foetoprotein were not detected in any of the eluates. The ratio of the concentration of albumin to the concentration of IgG was similar in extracts and eluates of all the normal tissue and in 3 of the malignant tissues indicating non-specific binding of IgG.
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PMID:Characterization of heat eluates of human malignant tissues. 38 13

Using corresponding monospecific antisera from the rabbit, the precipitation curves for albumin, alpha-1-antitrypsin, haptoglobin 1-1 and fibrinogen were produced. In parallel, four different dilutions of these antigens were examined by line immmunoelectrophoresis, employing the same antisera. The distance of the resulting line immune precipitates from the start served to calculate the amount of antigen-antiserum reacting with each other. After converting these values to the amount of antiserum used for producing the precipitation curves, the 'line antigen/antibody ratios' were drawn into the appropriate precipitation curves. All electroimmune precipitates (in this case, the 'line immune precipitates') were found to be located on the side of antigen excess of their corresponding precipitation curve.
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PMID:Determination of the position of electroimmune precipitates of antigen--antibody systems on their respective quantitative precipitation curves. 41 16

Fibrinogen synthesis in rabbits was evaluated following intravenous infusions of stage 3 degradation products of homologous fibrinogen or fibrin, prepared in vitro. Fibrinogen production was measured by determining the rate of appearance of 75SeM into circulating fibrinogen. Fibrinogen synthesis increased threefold after the administration of stage 3 FDP (D and E), dialyzed to remove LMW digestion fragments, In contrast, the fdp obtained by plasminolysis of crosslinked thrombin clots or of noncrosslinked ancrod or thrombin clots failed to enhance basal fibrinogen production. Accelerated fibrinogen production was not accompanied by alterations in haptoglobin concentration or by increased incorporation of 75SeM into haptoglobin. Fibrinogen synthesis was not increased after infusions of FPA and FPB.
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PMID:Regulation of fibrinogen biosynthesis: effect of fibrin degradation products, low-molecular-weight peptides of fibrinogenolysis, and fibrinopeptides A and B. 42 74

The relationship between the erythrocyte sedimentation rate (ESR) and plasma proteins was studied within homogenous clinical material and in vitro models. In acute phase reactions, fibrinogen was the likely cause of the ESR-elevation, but there were significant associations between the ESR and the concentrations of alpha 1-antitrypsin, C3, haptoglobin and albumin. In chronic diseases, the ESR-elevation was probably caused by fibrinogen, mono- or polyclonal increase of IgG, IgA, IgM alone or in combinations. In multiple myeloma of the IgG and IgA subtypes, significant correlations were found between the ESR and the monoclonal proteins or between the ESR and the percentage of plasma cells in bone marrow. Model studies showed that the ESR increased linearly with the concentrations of fibrinogen or gammaglobulin (IgG) when these exceeded normal thresholds. The ESR was slightly decreased by increasing concentrations of albumin. Albumin had a synergistic effect on the ESR together with gamma-globulin, but not together with fibrinogen.
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PMID:The relationship between the erythrocyte sedimentation rate (ESR) and plasma proteins in clinical materials and models. 53 82

Differences in mobility of free and complex-bound antigen molecules during electrophoresis in antibody-free and antibody-containing agarose gel were investigated with albumin, alpha-1-antitrypsin, haptoglobin and fibrinogen. The combination of line electrophoresis and one-dimensional single electroimmunodiffusion as designed for this purpose is described. Differences in time between the start of line electrophoresis and that of rockets, in view of their influence on the formation of the line precipitate, served as reference values. Three basic types of morphology of the line precipitate in the area of possible interaction between line and rocket precipitation were distinguished: total interruption, partial interruption and no interruption. By means of the time differences indicator system it was found that this apparent reduction in mobility during electroimmunodiffusion of the antigens tested was reversely proportional to the electrophoretic mobility of free antigens.
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PMID:Investigation of the apparent delay in mobility of albumin, alpha-1-antitrypsin, haptoglobin 1-1 and fibrinogen in electroimmunodiffusion. 82 59

Changes in plasma haptoglobin, total protein, hematocrit, and hemoglobin content of blood were studied in rats at various times during a 7-d exposure to oxygen at 760 torr. Plasma haptoglobin and other plasma proteins were fractionated and quantitatively evaluated for a 3-d exposure period. Total protein and haptoglobin were depressed after 7 d of exposure. Significant changes were not noted before this time. With a 3-d exposure, for which plasma proteins were fractionated, fibrinogen showed a considerable increase whereas albumin, gamma globulins, and the beta 1 globulin fraction decreased significantly. Individual variations in albumin and haptoglobin were correlated inversely to the hematocrit. These variations indicate that the altered composition of the plasma protein is due, in part, to a variable loss of the various plasma protein fractions as a result of increased vascular permeability.
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PMID:Changes in haptoglobin and other plasma proteins of rats during exposure to pure oxygen at 760 torr. 111 9

Proteins from grossly and histologically normal human aortic intimas and human aortic intima with fatty streaks or fibro-fatty lesions were extracted with 9 M urea mixture. Protein extracts were mixed with an internal absorbance calibrator (carbonic anhydrase) and subsequently separated by two-dimensional gel electrophoresis, silver stained, and quantitated by a laser beam densitometer. The vascular-origin proteins actin, tropomyosin-like proteins, tubulin, glycoprotein G35, and two myosin light chains were present in the highest amounts in normal aortic intima (27-year-old male). Quantitation of vascular-origin proteins in aortic intima with a fibro-fatty lesion from the same subject showed a slight decrease in relative amount of these proteins as compared to the normal intima. Several polypeptides (P15, P18, P60, P110b) and plasma-derived proteins not observed in the normal intima were found in fibro-fatty lesion (albumin, haptoglobin beta-chain, fibrinogen beta-chain, alpha 1-HS-glycoprotein). Other proteins which were present in very low amounts in the normal intima (transferrin, alpha 1-antitrypsin, apolipoprotein A-1, P56, P190) were found to be major proteins of intima with fibro-fatty lesion. Differences in relative amount of plasma-derived and vascular-origin proteins between normal intima and intima with fatty streaks, studied in a large number of specimens from 38 thoracic intimas and 18 paired abdominal intimas (16-34 years old) were less prominent. Statistically significant increases of the albumin/actin ratio were found in fatty streaks as compared to paired normal intimas as well as in the mean value of albumin/actin ratio in the group of fibro-fatty lesions (mean = 6.1) as compared to the group of fatty streaks (mean = 1.7) or normal intima (mean = 0.7). Several lesion unique proteins were observed; however, the frequency of the occurrence of these proteins in 41 specimens with lesion was low. No significant differences were observed in intima protein pattern and quantities of selected intima proteins between paired thoracic and abdominal aortas.
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PMID:Quantitative alteration of some aortic intima proteins in fatty streaks and fibro-fatty lesions. 128 71

In proliferative diseases of the homeopathic system before starting and at the end of treatment, the values of 8 acute phase factors were studied simultaneously, that is: seromucoid, sialic acid, alpha 1 acid glycoprotein, alpha 1 antitrypsin, haptoglobin, ceruloplasmin, transferrin, and fibrinogen. In chronic myeloid and lymphatic leukaemia no constant increase nor decrease of the concentration of any of the factors was found. In non-Hodgkin lymphoma the concentration of one factor -ceruloplasmin was constantly increased, and that of two factors--sialic acid and fibrinogen was decreased, while in plasmocytoma the concentration of two factors--haptoglobin and ceruloplasmin was constantly increased. At the end of treatment the concentration of certain factors was changing. In chronic myeloid leukaemia the concentration of ceruloplasmin, fibrinogen, and seromucoid was decreasing, while in non-Hodgkin lymphoma the concentration of haptoglobin and fibrinogen was increasing, in chronic lymphatic leukaemia the concentration of haptoglobin and increasing, in chronic lymphatic leukaemia the concentration of haptoglobin and transferrin was increasing, and in plasmocytoma the concentration was increasing of haptoglobin, sialic acid, and transferrin. The result of treatment in chronic myeloid leukaemia was good, in non-Hodgkin lymphoma and chronic lymphatic leukaemia--moderate, and in plasmocytoma it was least beneficial.
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PMID:[Factors of the "acute phase" in proliferative diseases of the hemopoietic system]. 129 50

A prospective study on 11 patients with temporal artery biopsy-proven arteritis examined the frequency and significance of anti-cardiolipin antibodies. Antibody levels in 7 patients were higher than 20 units but were not correlated with an inflammatory syndrome, as assessed by measurement of 4 inflammatory proteins (fibrinogen, C-reactive protein, orosomucoid and haptoglobin). These 7 patients were treated with steroids and their antibody levels returned to the normal range after 4 to 16 weeks of therapy, later than the inflammatory proteins. Two patients had slight increases of their anti-cardiolipin antibody levels, but no signs of clinical relapse or increases of inflammatory proteins were observed. In this study, no correlation was found between the presence of anti-cardiolipin antibodies and the occurrence of ischemic complications in 6 of the 11 patients.
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PMID:[Anti-cardiolipin antibodies in Horton's disease]. 130 Aug 62

The hepatic expression of albumin (Al) and plasma acute phase protein genes (APP) was examined during the development of rat liver and in response to inflammation of the dam. Throughout the 10- to 20-day gestation period the level of alpha 2-macroglobulin (alpha 2M) mRNA in fetal liver exceeded twice that of the adult liver. The concentrations of the other APP and Al mRNAs were 10-30% of those of the adult liver between days 10 and 13 of gestation, then increased to values which ranged from 40% for haptoglobin (Hp) to 80% for Al and alpha 1-acid glycoprotein (AGP) mRNAs on day 19 of gestation. The transition of fetuses to an extrauterine environment was followed by a temporary overexpression of the Hp gene and an increase of the fibrinogen (Fb), AGP and thiostatin (TST) mRNAs to adult levels. Fetal liver responded to inflammation of the mother by a transcriptional induction of all of the investigated APP genes, except for the Fb gene whose level of expression remained unchanged. The pattern of individual APP genes expression in maternal and fetal livers was similar and characteristic for the acute phase reaction.
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PMID:The expression of liver acute-phase protein genes during rat development and in response to inflammation of the dam. 137 3


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