Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q99581 (FEV)
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Human Gene/Protein
a disintegrin and metalloprotease domain 33 13.2
FEV 13.2
BNIP3L protein 13.2
FLJ20184 13.2
integrator complex subunit 12 11.9
GSTCD 11.7
CEP68 10.9
NLRP8 10.7
NPNT 10.7
ZGPAT 10.7
EML3 10.7
EMI domain-containing protein 2 10.4
SVIL 10.2
USP38 10.2
RNA polymerase II-associated protein 1 10.2
ZAN 10.0
PPT2 10.0
PEF 9.9
SPATS2L 9.9
GTF2H4 9.9
MAZR 9.9
E1A-F 9.8
IDH3B 9.8
THSD4 9.8
surfactant protein A1 9.8
ETV1 9.7
RAB4B 9.7
ROGDI 9.7
GLCCI1 9.5
CD99 protein 9.4
HLA-DP beta 9.3
IL13RA1 9.3
IDH3A 9.2
SEC24C 9.2
AGER 9.2
BTAF1 9.2
MEF 9.1
IRF3 protein 9.1
ZNF263 9.1
NLRP4 9.0
LGALS4 9.0
DDHD1 8.9
TNS1 8.8
ADAMTS15 8.8
receptor for advanced glycosylation end products 8.8
LUM 8.8
FAM13A 8.8
COPD 8.8
FIF 8.7
Tryptophan hydroxylase 2 8.6
WDR36 8.5
HTR4 8.5
SERPINE2 8.5
RAB1A 8.5
HYAL-1 8.5
PGAP3 8.4
LIME 8.4
CUBN 8.4
HLA-DQA2 8.3
adenylyl cyclase 2 8.3
PEA3 8.2
ATS 8.2
NFATC2 8.2
GPR126 8.0
ADAM19 8.0
EGLN2 8.0
V75 8.0
NYGGF4 8.0
FLI1 8.0
SNIP 8.0
PIF 7.9
RAD54B 7.9
PRDX5 7.9
ETV2 7.8
HHIP 7.8
SARP 7.8
ELF1 7.8
SFTPA1 7.8
SLC26A9 7.8
NSUN2 7.8
more...
Disease
Tracheobronchial dyskinesia 12.2
FIF 9.6
Respiratory bronchiolitis-associated interstitial lung disease 9.2
Bronchial wall thickening 9.2
COPD exacerbation 9.2
obstructive airway disease 9.1
Bronchiolitis obliterans 9.1
Bronchial hyperresponsiveness 8.8
COPD 8.8
Chronic respiratory failure 8.7
Eosinophilic bronchitis 8.7
Restrictive lung disease 8.5
small airways disease 8.5
chronic obstructive pulmonary disease 8.4
Systolic heart failure 8.4
Respiratory morbidity 8.3
Overlap syndrome 8.3
AAT deficiency 8.2
MSSD 8.2
Oral Mucositis 8.0
Meconium ileus 8.0
byssinosis 7.7
childhood asthma 7.7
sinobronchial syndrome 7.7
Airway obstruction 7.7
chronic bronchiolitis 7.5
ERS 7.5
reactive airway disease 7.3
emphysema 7.3
Exercise-induced asthma 7.1
peripheral primitive neuroectodermal tumor 7.0
BOS 7.0
chronic bronchitis 6.9
Skin toxicity 6.9
bronchorrhea 6.9
bronchiectasis 6.8
ASG 6.8
MDI 6.8
lung disease 6.7
cystic fibrosis 6.6
asthma 6.6
Microscopic polyangiitis 6.6
ICS 6.6
occupational lung disease 6.5
cough variant asthma 6.5
Cardiovascular morbidity 6.5
perennial rhinitis 6.5
bronchospasm 6.5
lymphangioleiomyomatosis 6.3
FUS 6.2
asthmatic bronchitis 6.2
DTD 6.2
Askin tumor 6.2
acute chest syndrome 6.1
seasonal rhinitis 6.1
rhinovirus infection 6.0
OHS 6.0
lung neoplasm 6.0
pancreatic insufficiency 6.0
Adrenal gland 6.0
Adrenal gland 6.0
bronchomalacia 5.9
stage I NSCLC 5.9
bronchiolitis 5.9
Hepatopulmonary syndrome 5.9
HFA 5.8
AA1 5.8
respiratory disease 5.8
USH2A 5.8
Rhinosinusitis 5.7
Occupational asthma 5.7
Thoracic 5.7
Pel 5.7
silicosis 5.6
asbestosis 5.5
Chlamydia pneumoniae infection 5.5
Allergic bronchopulmonary aspergillosis 5.5
pneumoconiosis 5.4
Ewing's sarcoma 5.4
interstitial lung disease 5.3
more...
Symptom
smokers cough 12.2
Increased work of breathing 11.7
runny eyes 10.9
Rhonchi 10.2
Air trapping 10.0
Quadriceps weakness 9.9
Lung hyperinflation 9.4
out of breath 9.1
Diaphragmatic weakness 9.0
sinus congestion 8.9
Hoover's sign 8.7
nocturnal cough 8.4
dry throat 7.8
Respiratory symptoms 7.8
chest tightness 7.7
Gasping 7.3
dyspnea 6.8
wheezing 6.7
catarrh 6.7
respiratory problem 6.6
persistent cough 6.6
productive cough 6.6
Nasal symptoms 6.5
chronic cough 6.2
exertional dyspnea 6.1
precordial pain 5.8
clubbing 5.8
cough 5.7
shortness of breath 5.5
labored breathing 5.5
orthopnea 5.4
hemoptysis 4.5
hypercapnia 4.4
tachypnea 4.2
twitching 4.2
Hudson 4.2
nasal congestion 4.1
hyperoxia 4.1
night sweats 4.0
Fluctuation 4.0
rales 3.9
sore throat 3.8
hoarseness 3.7
stridor 3.6
cachexia 3.6
exhaustion 3.2
rhinorrhea 3.1
tingling 2.9
nasal discharge 2.8
overweight 2.8
hunger 2.8
chills 2.8
snoring 2.7
chest pain 2.6
fatigue 2.6
discomfort 2.6
torticollis 2.6
discomfort 2.6
hypocapnia 2.5
alexithymia 2.5
cyanosis 2.4
weakness 2.3
sneezing 2.3
acute pain 2.3
Depressive symptoms 2.3
heartburn 2.2
sleepiness 2.2
tremor 2.1
dysuria 2.0
analgesia 1.8
nausea 1.5
epigastric pain 1.5
Ill 1.4
anorexia 1.1
headache 1.0
numbness 0.9
ENT 0.9
Welt 0.8
paresis 0.7
back pain 0.7
more...
Drug
Denufosol tetrasodium 11.7
Meptin 10.9
Foradil 10.5
Foradil 10.5
Foradil 10.5
Doxofylline 9.9
Vanceril 9.5
Pulmozyme 9.5
Roflumilast 9.4
Roflumilast 9.4
Spiriva 9.2
Fluticasone furoate 9.2
Accolate 9.0
Ciclesonide 8.7
Oxitropium bromide 8.7
Berotec 8.6
Alupent 8.6
Alupent 8.3
Ventolin 8.2
Ludiomil 8.1
Ludiomil 8.1
Serevent 8.0
Bricanyl 7.9
Becotide 7.8
Oxycon 7.7
Atrovent 7.6
Solon 7.6
Ipratropium bromide 7.5
Salbutamol 7.5
Intal 7.4
Fluticasone propionate 7.4
Coal tar 7.3
ETS 7.2
Ethane 7.1
Budesonide 7.1
Marimastat 7.1
PFT 6.9
Omalizumab 6.9
Mepolizumab 6.9
Deflazacort 6.8
Prograf 6.8
MINO 6.7
Malonaldehyde 6.6
Talc 6.5
Syrup 6.5
Asthma 6.3
Fenoterol 6.3
Dimethylformamide 6.3
Cefaclor 5.7
Nedocromil sodium 5.7
MRC 5.6
Pirfenidone 5.3
Azithromycin 5.3
Citric acid 5.2
KCL 5.2
Allergen 5.0
ACT 4.7
Aminoguanidine 4.5
Ramipril 4.5
Omeprazole 4.3
Orphan 4.2
Diurnal 4.1
PPA 4.0
Helium 4.0
Nitric Oxide 3.9
Theophylline 3.8
Wine 3.8
Rosiglitazone 3.6
Tacrolimus 3.5
Xanthium 3.5
SF6 3.5
Histamine 3.4
ROC 3.3
Prednisone 3.2
DHT 3.1
IL-11 3.1
DHT 3.1
Horizon 3.0
Fraction 2.9
CCL 2.9
more...
Enzyme
nicotinamide N-methyltransferase 6.7
jararhagin 5.9
BAL 5.5
iduronate-2-sulfatase 5.3
CYP27A1 5.2
LTA4 hydrolase 5.0
tryptophan hydroxylase 4.8
neutrophil elastase 4.7
cathepsin S 4.3
SPT 4.2
aromatic L-amino acid decarboxylase 4.2
cysteine synthase 4.0
3-hydroxyacyl-CoA dehydrogenase 3.8
3-hydroxyacyl-CoA dehydrogenase 3.8
gamma-glutamylcysteine synthetase 3.8
deoxyribonuclease 3.7
SST 3.7
deoxyribonuclease 3.7
PAT 3.5
TSP-1 3.5
SPT 3.4
tryptase 3.4
cystathionine beta-synthase 3.3
MIP 3.3
bromelain 3.2
MMP-3 3.1
PDE 3.0
elastase 2.9
heme oxygenase 2.8
chalcone synthase 2.7
phosphodiesterase 2.6
aspartate aminotransferase 2.5
succinic dehydrogenase 2.5
prostate-specific membrane antigen 2.5
cathepsin K 2.4
AST 2.3
CYP3A4 2.2
MMP 2.2
NADH dehydrogenase 2.2
chitinase 2.2
hormone-sensitive lipase 2.2
PAH 2.1
ADH 2.1
citrate synthase 2.1
DNase 1.9
pyruvate kinase 1.9
hexokinase 1.9
peroxiredoxin 1.9
catalase 1.7
complex I 1.7
collagenase 1.7
isocitrate dehydrogenase 1.6
glutathione peroxidase 1.6
glutathione reductase 1.6
granzyme B 1.5
isocitrate dehydrogenase 1.5
CD13 1.4
phosphofructokinase 1.3
succinate dehydrogenase 1.2
MDR 1.1
hyaluronidase 1.1
CD10 1.0
kinesin 0.9
alanine aminotransferase 0.9
peroxidase 0.8
luciferase 0.8
phosphorylase 0.8
glutathione S-transferase 0.8
diaphorase 0.7
ACE 0.7
NQO1 0.6
hyaluronidase 0.6
caspase-1 0.6
superoxide dismutase 0.6
GSK 0.5
caspase-8 0.5
NOS 0.4
MAP 0.4
glucose-6-phosphate dehydrogenase 0.3
NO synthase 0.3
more...
Compound
Fluticasone 9.4
Nedocromil 9.3
Formoterol 9.3
Mometasone 9.2
Fluticasone 9.1
Zafirlukast 9.0
AMCC 8.3
Ipratropium 8.3
Methacholine 8.2
Salmeterol 7.9
8-HETE 7.7
Salbutamol 7.5
Beclomethasone 7.4
6-trans-LTB4 7.2
Terbutaline 7.2
gamma-Glutamylcysteine 7.1
HFA 7.1
Montelukast 7.1
20-OH-LTB4 6.9
ECP 6.8
ECP 6.7
ECP 6.7
20-COOH-LTB4 6.7
SVC 6.7
AAT 6.6
Xamoterol 6.6
CIPC 6.6
S-phenyl 6.6
S-phenyl 6.5
Fexofenadine 6.5
Levoglucosan 6.5
SD 25 6.4
Glycopyrrolate 6.4
Triamcinolone 6.3
Leucovorin 6.3
Triphosphate 6.3
TDI 6.3
CD 3 6.2
DNC 6.1
C 6 6.0
3GC 5.9
benzo[ghi]perylene 5.9
Cefaclor 5.7
Tobramycin 5.7
Azithromycin 5.7
Mannitol 5.7
pentanedioic acid 5.7
11-dehydro-thromboxane 5.7
DPI 5.6
Mannitol 5.6
Disodium cromoglycate 5.5
MAOA 5.4
Lipoxin A4 5.4
Geigy 5.4
Azan 5.3
benzo[a]anthracene 5.2
S-benzyl 5.1
Lansoprazole 5.1
BAL 5.0
PRN 5.0
LTD 5.0
TET 4.9
TET 4.9
20-HETE 4.9
Styrene 4.8
HEI 4.7
HFIP 4.7
PAE 4.6
TBC 4.6
AIR 4.6
HCP 4.4
MDR 4.4
Crocin 4.4
SDA 4.3
Leukotriene B4 4.3
Asbestos 4.2
HCP 4.2
5-HETE 4.1
Thiobarbituric acid 4.1
PGJ2 4.1
more...