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Query: UNIPROT:Q99581 (FEV)
 3,296 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The prevalence of respiratory symptoms and acute and chronic changes in ventilatory function were studied in three groups of textile workers: 68 workers with exposure to synthetic fibers only, 30 with previous exposure to cotton, and 77 with previous exposure to hemp. The prevalence of dyspnea, grade 3 to 4, was significantly lower (P less than .01) in workers with a history of exposure to synthetic fibers only than in those previously exposed to hemp or cotton. No case of byssinosis was found in any of the workers studied. Values in ventilatory-function tests (FEV 1.0, FVC and MEF 50%) were significantly reduced during the work shift on Monday and Thursday. The Monday MEF 50% preshift values were significantly lower than expected in all three groups of workers. A comparison of the 1963-1973 data on the 77 workers previously exposed to hemp showed a lower prevalence of most chronic respiratory symptoms and smaller acute FEV1.0 and FVC reductions when they worked with synthetic fibers (1973) than when they were exposed to hemp (1963).
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PMID:Respiratory-function changes in textile workers exposed to synthetic fibers. 93 43

Closing volume (single breath nitrogen test), regional ventilation and perfusion (using intravenous xenon-133), and total lung function (TLC, VC, and FEV) were measured before and after intramuscular administration of 250 mug 15-methyl prostaglandin F2alpha (15-me PGF2alpha) in 10 healthy women. The cardiac output was measured with the Minnesota impedance cardiograph model 304A and the transthoracic impedance was used as an expression of the thoracic fluid volume. The slope of the alveolar plateau on the closing volume tracing showed a 271% increase 20 minutes after the prostaglandin administration, at which time the closing volume per cent (CV%) had decreased (P less than 0-01) and the closing capacity (CC%) had increased (P less than 0-05). Vital capacity (VC) decreased (P less than 0-01), residual volume (RV) increased (P less than 0-01), and the total lung capacity (TLC) remained unchanged. The maximal decrease (9%) in FEV1 was seen after 20 minutes. All these measurements except the slope of the alveolar plateau returned to control levels after 60 minutes. The redistribution of regional ventilation was more pronounced than that of the regional pulmonary blood flow. No change was observed in cardiac output and transthoracic impedance. None of the patients experienced any dyspnoea. Our results are consistent with a more pronounced effect of prostaglandin F2alpha on the small airways (the alveolar plateau) than on the larger airways (FEV1). In cases where an increase in the slope of the alveolar plateau is observed, the closing volume per cent should not be used as a measurement of the lung disease. It is concluded that the single breath nitrogen test (N2 closing volume) is more sensitive than the conventional tests.
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PMID:Pattern of total and regional lung function in subjects with bronchoconstriction induced by 15-me PGF2 alpha. 101 40

The dyspnea grade (MRC scale) was confronted with the arterial oxygen tension (PaO2) measured at rest in a group of 51 patients with chronic obstructive lung disease with moderate or severe impairment of ventilatory function (FEV 1.0 less than 1.5 1). For the group as a whole no correlation was found, but in the "bronchitic" subgroup (clinical-roentgenologic and biologic criteria) a tendency of PaO2 to decrease with the increase in dyspnea severity was apparent. The linear correlation coefficient did not attain the significance threshold owing to the limited number of observations (r = 0.46; p greater than 0.05).
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PMID:Breathlessness and blood oxygen tension in patients with chronic bronchitis and emphysema. 102 58

The breath-holding CO transfer factor and transfer coefficient were correlated with the severity of dyspnea in 37 patients with moderate or severe obstructive lung disease FEV 1.0 less than 1.5 1) No correlation was evident when the whole group was considered. When the patients were subdivided into "bronchitics", "intermediate" and "emphysematous" a correlation between dyspnea severity and gas transfer appeared for the latter subgroup; this correlation was statistically significant for the transfer coefficient.
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PMID:Breathlessness and transfer factor for the lung in chronic obstructive lung disease. 121 3

Dyspnea, leg effort (Borg 0 to 10 scale), ventilation, and heart rate (VEmax/VEcap; HRmax/HRcap expressed as a percentage of capacity) were measured at maximal exercise (cycle ergometer) in 97 patients with chronic airflow limitation (CAL) (FEV, 46.6 +/- 14.23% of predicted) and compared with 320 matched control subjects. Patients with CAL achieved a maximum power output of 86 +/- 39.5 W (60 +/- 23.2% of predicted) compared with 140 +/- 37.5 W (98 +/- 14.5% of predicted) in controls (p less than 0.0001), VEmax/VEcap was 72 +/- 19.3% compared with 53 +/- 18.6% (p less than 0.0001), and HRmax/HRcap was 76 +/- 13.5% compared with 82 +/- 13% (p less than 0.001). These findings were expected. The median intensity of dyspnea was 6 (severe to very severe) and leg effort was 7 (very severe) in both groups, and these findings were unexpected. The patients with CAL were handicapped by an increase in both dyspnea and peripheral muscular effort relative to the actual power output. The rating of dyspnea exceeded leg effort in 25 (26%) of CAL versus 69 (22%) control subjects: the rating of leg effort exceeded dyspnea in 42 (43%) CAL and 117 (36%) control subjects; both were rated equally in 30 (31%) CAL and 134 (42%) control subjects, respectively (NS). VEmax/VEcap and HRmax/HRcap were not significantly different in those limited by dyspnea, leg fatigue, or a combination of both. All values are expressed +/- SD.
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PMID:Exercise capacity and ventilatory, circulatory, and symptom limitation in patients with chronic airflow limitation. 836 56

We studied 27 patients (seven male, 20 female) with stable mild-to-moderate asthma to measure their level of physical fitness and to determine if a relationship existed between aerobic fitness and the degree of airway reactivity, expiratory flow rates, or the amount of habitual leisure-time physical activity. Nonspecific bronchial hyperreactivity (NSBHR) was quantified by methacholine inhalation challenge. On a separate day, exercise capacity was evaluated with incremental exercise testing to exhaustion after bronchodilator pretreatment. The level of physical activity was assessed with a validated written questionnaire. FEV, was 78 +/- 13% predicted prebronchodilator and 92 +/- 14% predicted postbronchodilator. The mean provoking concentration of methacholine that caused a 20% decrease in FEV1 (PC20) was 1.14 +/- 1.38 mg/ml and ranged from 0.019 to 5.71 mg/ml. There was no correlation between PC20 and prebronchodilator FEV1 r = 0.37, p greater than 0.05). Mean maximal oxygen uptake (VO2max) was not significantly different from predicted normal values (36.9 +/- 10.8 versus 38.5 +/- 5.3, p = 0.32). Mean maximal O2pulse (maximal heart rate/VO2max), anaerobic threshold, and dyspnea index were within normal limits. There was no relationship between VO2max and FEV1 when expressed as percentages of predicted values (r = 0.08, p = 0.71) or between VO2max and PC20 (r = 0.23, p = 0.25). There was, however, a significant relationship between VO2max and the level of habitual leisure-time activity (F = 3.64, p less than 0.05). Results from the exercise questionnaire suggested that asthmatics perceive their disease as a limiting factor to improved aerobic fitness and that they lack adequate knowledge about asthma and exercise.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Physiologic and nonphysiologic determinants of aerobic fitness in mild to moderate asthma. 155 93

The efficacy of inhaled high-dose beclomethasone dipropionate (BDP) in intrinsic and cortico-dependent asthma was studied in 12 asthmatics (3 males and 9 females), average age 39 years (range 17-62 years), with a mean duration of the disease of 9 years (range 2-20 years). The patients were instructed to use one actuation (250 micrograms), three times daily or two actuations three times daily in severe cases in which dyspnoea persisted during the intake of oral corticosteroids. The results during the 6 month follow-up period were: Clinical: dyspnoea, wheeze and cough disappeared or diminished, oral administration of corticosteroids stopped or the daily dose was reduced, the intake of beta-agonists decreased; Functional: after 2-4 weeks, in almost all cases, the base line values of FEV 1.0 and Raw were normal and hyperinflation significantly diminished after the first month of BDP therapy. Clinical and functional improvement were maintained during the follow-up period; no side-effects were revealed.
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PMID:Clinical management of bronchial asthma with inhaled high-dose beclomethasone dipropionate (Beclomet 250--Orion). 184 40

Three patients presented respiratory abnormalities following Crotalus durissus snakebite. These abnormalities appeared in the first 48 h after the snake bite and consisted of dyspnea, tachypnea, use of accessory muscles of respiration (cases 1 and 2) and flaring of the nostrils (case 2). Cases 1 and 2 developed acute respiratory failure. Case 2, 24 h after the snakebite presented difficult breathing and periods of apnea. He was intubated in the emergency room and transferred to the intensive case unit where he arrive with spontaneous breathing. His respiratory pattern worsened and measurement of arterial pH and blood gases showed metabolic and respiratory acidosis with partial carbon dioxide pressure increasing from 40 to 50.3 mmHg compatible with acute ventilatory failure. Both patients needed mechanical ventilation. Weaning from the ventilator was accomplished after 33 days in case 1 and after 15 days in case 2. Both patients also presented acute renal failure treated with peritoneal dialysis with full recovery of the renal function. Measurements of forced vital capacity (FVC) and forced expiratory volume in the first second (FEV 1.0) was carried out 58 hours after the snakebite in case 3. Both FVC and FEV 1.0 were reduced in relation to the predicted values (60 and 67% respectively) but the ratio FEV 1.0/FVC was in the normal range. These findings were compatible with a restrictive pattern of ventilatory failure. Serial measurements showed progressive increase of both FVC and FEV 1.0 reaching 72 and 79% of the predicted values, respectively, in the 10th day after the snakebite.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Respiratory involvement secondary to crotalid ophidian bite (Crotalus durissus)]. 184 45

The relationship between loss of pulmonary function and the presence of asbestos-related pleural disease was evaluated for 913 Minnesota asbestos workers. Asbestos-related pleural disease was categorized as circumscribed plaques or diffuse thickening. Compared with workers with normal pleura, workers with plaques had a decreased mean percentage for predicted forced vital capacity (FVC) and predicted forced expiratory volume in 1 s (FEV1.0). Diffuse thickening was associated with more profound decreases in FVC and FEV1.0. No relationship was seen between FEV % [(100 x FEV1.0)/FVC)] and either type of pleural disease. Dyspnea was associated with diffuse thickening more so than plaques. These results remained after control for pack-years of smoking, extent of parenchymal disease, and the presence of pulmonary disease history. Pleural plaques and diffuse pleural thickening were considered independent risk factors for the loss of lung function.
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PMID:Effects of asbestos-related pleural disease on pulmonary function. 206 56

The long term outcome for 88 patients with bullous emphysema who had operations was analysed from the clinical, respiratory function and occupational point of view. In order to reduce to the minimum any bias which would be likely to appear as a result of a decrease in the number of patients with time respiratory function parameters were compared to those of a restricted number of patients for whom we knew all the values for each period determined. Before the operation all the patients showed radiological signs of bullous emphysema; the respiratory function measurements in 66 of them showed bronchial obstruction with distension, hypoxaemia at rest without hypercapnia. The clinical follow up and respiratory function was spread over more years. It showed a post operative improvement in dyspnoea which was perceptible in 77% of patients at 2 years, 68% at 3 years, 60% at 4 years, 51% at 5 years, 32% at 10 years. 2/3 of the patients who were working before the operation had taken up their normal work following it. the survival levels were 86% at 1 year, 83% at 2 years, 80% at 3 years, 78% at 4 years, 77% at 5 years, 73% at 6 years, 73% at 6 years, 58% at 10 years. Of 20 patients who died 12 had died of respiratory failure. All the spirographic parameters had improved following the operation but a secondary deterioration was noted around the 5th post operative year for the vital capacity, and at the third year for residual volume, FEV 1, and the FEV 1/VC ratio as well as PAO2.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Long-term outcome of surgically treated bullous emphysema]. 210 80


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