Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:Q99542 (
matrix metalloproteinase
)
15,999
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
matrix metalloproteinase
15999
MMP-9
3202
MMP-2
2664
collagen
2332
Mol
1586
metalloproteinase
1074
Sep
1060
MMP
928
MMP-1
927
vascular endothelial growth factor
914
EPA
803
tumor necrosis factor
799
cytokine
764
MMP-3
675
TIMP-2
661
MMP9
597
MT1-MMP
550
MMP-13
527
p38
507
matrix metalloproteinase 2
489
TNF
478
collagenase
463
IL-6
461
fibronectin
454
ERK1
434
E-cadherin
377
MMP2
362
ERK
328
urokinase-type plasminogen activator
325
MAPK
325
type I collagen
323
stromelysin
306
cyclooxygenase-2
287
extracellular signal-regulated kinase
285
caspase-3
285
p65
274
lipopolysaccharide
272
AKT
272
AP-1
268
IL-8
268
more...
Disease
cancer
3393
tumor
3095
breast cancer
672
tumor growth
569
carcinoma
566
metastases
529
tumor progression
526
osteoarthritis
465
atherosclerosis
454
tumorigenesis
341
melanoma
339
stroke
328
hepatocellular carcinoma
314
lung cancer
296
arthritis
293
carcinogenesis
288
ischemia
283
rheumatoid arthritis
275
hypertension
275
plaque
274
diabetes
271
adenocarcinoma
270
glioma
249
prostate cancer
246
squamous cell carcinoma
230
MCF
203
myocardial infarction
200
colorectal cancer
187
heart failure
183
gastric cancer
182
ovarian cancer
167
liver fibrosis
160
cerebral ischemia
159
colon cancer
156
pancreatic cancer
147
glioblastoma
147
fibrosarcoma
146
asthma
142
osteosarcoma
138
chronic obstructive pulmonary disease
134
more...
Symptom
pain
108
thinning
41
skin damage
34
anesthesia
29
seizures
27
respiratory distress
25
functional recovery
23
weakness
17
erythema
16
hyperoxia
16
hypothermia
13
angina
13
dry eye
12
low back pain
11
fatigue
11
starvation
10
acidity
10
chest pain
9
diarrhea
9
arthralgia
9
cough
8
headache
8
collapse
7
cachexia
6
dyspnea
6
back pain
6
overweight
6
syncope
5
Neuropathic pain
5
myalgia
5
discomfort
5
discomfort
5
ataxia
5
abdominal pain
4
skin irritation
4
bone pain
4
stigma
4
exhaustion
4
Scratch
4
constipation
3
more...
Drug
Gelatin
194
Dermatol
180
Cardiovasc
85
lysine
75
Doxycycline
63
ROS
63
IFN-gamma
56
uPA
55
CSF
50
Monit
44
IL-2
35
MAP
33
Batimastat
31
Batimastat
31
Angiotensin II
27
Gel
27
Marimastat
26
CTX
26
CTX
25
vitamin E
25
CTX
24
Asthma
23
Asn
23
ETS
20
Ilomastat
18
ascorbate
18
CCL
16
Retinoic acid
13
Epigallocatechin
13
Simvastatin
12
Ethanol
12
p75
12
Indomethacin
12
ICI
10
MRC
10
IFN-beta
10
Emodin
9
Taxol
9
Vitamin A
9
CaCl2
9
more...
Enzyme
collagenase
1731
mitogen-activated protein kinase
1297
MMP
1052
MMP-3
818
ERK
538
matrix metalloproteinase 2
406
urokinase-type plasminogen activator
406
matrix metalloproteinase 9
328
focal adhesion kinase
326
protein kinase
298
caspase-3
230
luciferase
206
protein kinase C
206
plasmin
201
MEK
179
tissue plasminogen activator
145
phosphatidylinositol 3-kinase
140
peroxidase
138
superoxide dismutase
138
interstitial collagenase
130
reverse transcriptase
129
elastase
126
cathepsin K
107
catalase
96
alkaline phosphatase
85
NADPH oxidase
83
thrombin
83
trypsin
82
phosphoinositide 3-kinase
75
NADPH oxidase
74
neutrophil elastase
70
furin
69
NO synthase
64
renin
63
alanine aminotransferase
62
ACS
61
stromelysin-3
54
aspartate aminotransferase
52
PARP
51
proteasome
51
more...
Compound
Dec
1153
DNA
682
oxygen
644
Clin
502
TNF
478
acetate
351
nitric oxide
337
water
335
zinc
331
MDA
311
calcium
272
MTT
250
glucose
248
tyrosine
218
cysteine
204
serine
198
sodium
162
Collagen
159
phosphate
152
PEG
151
sulfate
130
arginine
123
lysine
120
PEG
119
THP
116
THP
116
Gly
113
leucine
113
MEK
107
Cardiol
105
hydrogen
104
alanine
101
retinoic acid
100
ASA
98
ethanol
98
methionine
86
hyaluronic acid
79
SDS
78
GSH
76
GSH
76
more...