Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q99542 (matrix metalloproteinase)
15,999 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
matrix metalloproteinase 15999
MMP-9 3202
MMP-2 2664
collagen 2332
Mol 1586
metalloproteinase 1074
Sep 1060
MMP 928
MMP-1 927
vascular endothelial growth factor 914
EPA 803
tumor necrosis factor 799
cytokine 764
MMP-3 675
TIMP-2 661
MMP9 597
MT1-MMP 550
MMP-13 527
p38 507
matrix metalloproteinase 2 489
TNF 478
collagenase 463
IL-6 461
fibronectin 454
ERK1 434
E-cadherin 377
MMP2 362
ERK 328
urokinase-type plasminogen activator 325
MAPK 325
type I collagen 323
stromelysin 306
cyclooxygenase-2 287
extracellular signal-regulated kinase 285
caspase-3 285
p65 274
lipopolysaccharide 272
AKT 272
AP-1 268
IL-8 268
more...
Disease
cancer 3393
tumor 3095
breast cancer 672
tumor growth 569
carcinoma 566
metastases 529
tumor progression 526
osteoarthritis 465
atherosclerosis 454
tumorigenesis 341
melanoma 339
stroke 328
hepatocellular carcinoma 314
lung cancer 296
arthritis 293
carcinogenesis 288
ischemia 283
rheumatoid arthritis 275
hypertension 275
plaque 274
diabetes 271
adenocarcinoma 270
glioma 249
prostate cancer 246
squamous cell carcinoma 230
MCF 203
myocardial infarction 200
colorectal cancer 187
heart failure 183
gastric cancer 182
ovarian cancer 167
liver fibrosis 160
cerebral ischemia 159
colon cancer 156
pancreatic cancer 147
glioblastoma 147
fibrosarcoma 146
asthma 142
osteosarcoma 138
chronic obstructive pulmonary disease 134
more...
Symptom
pain 108
thinning 41
skin damage 34
anesthesia 29
seizures 27
respiratory distress 25
functional recovery 23
weakness 17
erythema 16
hyperoxia 16
hypothermia 13
angina 13
dry eye 12
low back pain 11
fatigue 11
starvation 10
acidity 10
chest pain 9
diarrhea 9
arthralgia 9
cough 8
headache 8
collapse 7
cachexia 6
dyspnea 6
back pain 6
overweight 6
syncope 5
Neuropathic pain 5
myalgia 5
discomfort 5
discomfort 5
ataxia 5
abdominal pain 4
skin irritation 4
bone pain 4
stigma 4
exhaustion 4
Scratch 4
constipation 3
more...
Drug
Gelatin 194
Dermatol 180
Cardiovasc 85
lysine 75
Doxycycline 63
ROS 63
IFN-gamma 56
uPA 55
CSF 50
Monit 44
IL-2 35
MAP 33
Batimastat 31
Batimastat 31
Angiotensin II 27
Gel 27
Marimastat 26
CTX 26
CTX 25
vitamin E 25
CTX 24
Asthma 23
Asn 23
ETS 20
Ilomastat 18
ascorbate 18
CCL 16
Retinoic acid 13
Epigallocatechin 13
Simvastatin 12
Ethanol 12
p75 12
Indomethacin 12
ICI 10
MRC 10
IFN-beta 10
Emodin 9
Taxol 9
Vitamin A 9
CaCl2 9
more...
Enzyme
collagenase 1731
mitogen-activated protein kinase 1297
MMP 1052
MMP-3 818
ERK 538
matrix metalloproteinase 2 406
urokinase-type plasminogen activator 406
matrix metalloproteinase 9 328
focal adhesion kinase 326
protein kinase 298
caspase-3 230
luciferase 206
protein kinase C 206
plasmin 201
MEK 179
tissue plasminogen activator 145
phosphatidylinositol 3-kinase 140
peroxidase 138
superoxide dismutase 138
interstitial collagenase 130
reverse transcriptase 129
elastase 126
cathepsin K 107
catalase 96
alkaline phosphatase 85
NADPH oxidase 83
thrombin 83
trypsin 82
phosphoinositide 3-kinase 75
NADPH oxidase 74
neutrophil elastase 70
furin 69
NO synthase 64
renin 63
alanine aminotransferase 62
ACS 61
stromelysin-3 54
aspartate aminotransferase 52
PARP 51
proteasome 51
more...
Compound
Dec 1153
DNA 682
oxygen 644
Clin 502
TNF 478
acetate 351
nitric oxide 337
water 335
zinc 331
MDA 311
calcium 272
MTT 250
glucose 248
tyrosine 218
cysteine 204
serine 198
sodium 162
Collagen 159
phosphate 152
PEG 151
sulfate 130
arginine 123
lysine 120
PEG 119
THP 116
THP 116
Gly 113
leucine 113
MEK 107
Cardiol 105
hydrogen 104
alanine 101
retinoic acid 100
ASA 98
ethanol 98
methionine 86
hyaluronic acid 79
SDS 78
GSH 76
GSH 76
more...