Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q96DG6 (Pseudomonas)
 76,258 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cells of all Brucella species were agglutinated by the basic protein-reactive lectins of Mangifera indica and Persea americana. Cells of non-smooth strains including B. ovis and B. canis but not smooth strains were also agglutinated by concanavalin A. These lectins also reacted in a similar pattern with lipopolysaccharide extracts of these organisms. The lectin from Bandeiraea simplicifolia precipitated with the lipopolysaccharide antigens of smooth Brucella organisms and with those of serologically cross-reactive strains of Escherichia coli, Pseudomonas maltophilia, Salmonella and Yersinia enterocolitica but not with antigenically unrelated strains.
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PMID:The interaction of Brucella cell surface components with plant agglutinins. 620 71

Norfloxacin is a quinolinecarboxylic acid compound. We examined the in vitro activity of this compound against gram-positive and -negative species, including anaerobic species. It inhibited 90% (MIC90) of strains of Escherichia coli at 0.05 microgram/ml, Klebsiella sp. at 0.4 microgram/ml, Salmonella and Shigella spp. at 0.1 microgram/ml, Citrobacter sp. at 0.4 microgram/ml, Enterobacter cloacae at 0.2 microgram/ml, Enterobacter aerogenes at 0.4 microgram/ml, and Enterobacter agglomerans at 0.2 microgram/ml. The MICs of Proteus mirabilis, Morganella sp., Proteus vulgaris, Proteus rettgeri, and Providencia sp. were 0.1, 0.2, 0.8, 0.3, and 1.6 micrograms/ml, respectively. The MIC90 of Serratia sp. was 1.6 micrograms/ml, and that of Acinetobacter sp. was 6.3 micrograms/ml. For Pseudomonas aeruginosa the MIC50, the MIC75, and the MIC90 were 0.8, 1.6, and 3.1 micrograms/ml, respectively. The MIC50 of Pseudomonas maltophilia was 3.1 micrograms/ml, and the MIC90 was 12.5 micrograms/ml. Yersinia, Arizona, and Aeromonas all were inhibited at concentrations below 1 microgram/ml, as was Campylobacter. The activity of the compound against gram-positive species was less impressive: the MIC90s of Staphylococcus aureus, Streptococcus pyogenes, Streptococcus agalactiae, and Streptococcus faecalis were 1.6, 6.3, 3.1, and 12.5 micrograms/ml, respectively. All Listeria strains were inhibited by 3.1 micrograms/ml. The activity of norfloxacine was not affected by the type of medium, pH, or inoculum size. There was no major difference between MIC and minimum bactericidal concentration values. Norfloxacin inhibited bacteria in every species which was resistant to ampicillin, carbenicillin, cephalexin, gentamicin, and trimethoprim at concentrations lower than those of aminothiazolyl cephalosporins, moxalactam, and aminoglycosides.
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PMID:In vitro activity of norfloxacin, a quinolinecarboxylic acid, compared with that of beta-lactams, aminoglycosides, and trimethoprim. 621 95

Pefloxacin is a new methyl-4-piperazinyl quinolone. It had MIC90 values of less than 0.01 to 0.8 micrograms/ml for the majority of Escherichia coli, Klebsiella, oxytoca, Citrobacter, Providencia, Enterobacter cloacae, Enterobacter aerogenes, Morganella and Proteus mirabilis. It inhibited ampicillin, cephalexin and nalidixic acid resistant isolates of these species. Against Pseudomonas the pefloxacin MIC90 was 3.1 micrograms/ml. Staphylococcus aureus had a MIC50 of 0.4 micrograms/ml and a MIC90 of 0.8 micrograms/ml and S. faecalis had a MIC90 of 3.1 micrograms/ml. Pefloxacin inhibited Salmonella spp., Salmonella typhi, Shigella spp., Yersinia, Aeromonas, toxigenic E. coli at concentrations of less than 0.05 to 1.6 micrograms/ml, including ampicillin and trimethoprim resistant strains. There was a minimal difference in MIC and MBC values in broth or serum, but major changes in MIC and MBC values occurred in acid urine. Increase in MIC values occurred with repeated transfer in broth or urine.
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PMID:In vitro activity of pefloxacin compared to that of quinolones and other antimicrobial agents. 624 47

Bacteriological evaluation was made on cefotiam (CTM), a new broad-spectrum cephalosporin antibiotic, and the following results wer obtained. 1) CTM has shown very potent antibacterial activities against Staphylococcus aureus, Escherichia coli, Edwardsiella tarda, Citrobacter intermedius, Salmonella, Klebsiella, Proteus mirabilis, Proteus rettgeri, Proteus inconstans, Yersinia enterocolitica, Aeromonas hydrophila, Plesiomonas shigelloides and Pseudomonas putrefaciens. 2) Streptococcus faecalis, Enterobacter and Proteus morganii isolated from urine, Serratia and glucose non fermentative Gram-negative bacilli except Pseudomonas putrefaciens, were almost insusceptible to cefotiam.
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PMID:[Antibacterial activities of cefotiam against various pathogens isolated from clinical materials (author's transl)]. 628 18

The activity of cefotaxime was compared with that of ampicillin, moxalactam, and cefoperozone against 50 isolates of Haemophilus influenzae and with that of ampicillin, carbenicillin, cephalothin, cefoxitin, cefamandole, cefazolin, and several other established and investigational beta-lactam antibiotics against several hundred isolates of gram-negative aerobic enteric bacilli. Minimal inhibitory concentrations of the drugs were determined by the agar plate dilution technique for H. influenzae and by the microtiter broth dilution technique for the other pathogens. Cefotaxime was the most active agent against H. influenzae; it was 20 times more active than ampicillin. It was also the most active agent against Escherichia coli, Klebsiella pneumoniae, nontyphoid Salmonella species, and Yersinia enterocolitica. Cefotaxime was among the most active agents against Enterobacter cloacae, Citrobacter species, Shigella species, Proteus mirabilis, and Acinetobacter calcoaceticus. None of the new cephalosporins or penicillin inhibited greater than 90% of the isolates of Pseudomonas aeruginosa at concentrations of less than or equal to 16 micrograms/ml; these drugs were, however, more active than carbenicillin.
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PMID:Comparative activity of cefotaxime and selected beta-lactam antibiotics against Haemophilus influenzae and aerobic gram-negative bacilli. 629 90

The in vitro activity of cefmenoxime (SCE 1365), a new cephalosporin derivate was compared with two other "third generation" cephalosporins: cefotaxime and moxalactam. Cefmenoxime as cefotaxime and moxalactam were very active against 305 cephalosporinase-producing and cephalosporinase-non-producing Enterobacteriaceae. Cefmenoxime was the most active against Serratia marcescens, Citrobacter freundii, Morganella morganii, Salmonella, Shigella and Yersinia enterocolitica with a mean MIC at least twice lower. Several strains of the species Hafnia alvei, Providencia stuartii and Proteus vulgaris were more resistant. Against Haemophilus influenzae, the activity of the three cephalosporins was higher with a mean MIC between 0,030 and 0,040 microgram/ml. Against carbenicillin-sensible or carpenicillin-resistant Pseudomonas aeruginosa or Acinetobacter calcoaceticus, the three cephalosporins were not performant. Against Staphylococcus aureus, cefmenoxime and cefotaxime had an identical activity with a mean MIC of 1,5 microgram/ml against methicillin-sensible strains and a mean MIC of 5,5 micrograms/ml against methicillin-resistant strains.
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PMID:[In vitro bacteriostatic activity of cefmenoxime (SCE 1365), cefotaxime and moxalactam]. 631 95

The 2-h stool-screening test (SST) (API System S.A., Montalieu-Vercieu, France) was used to screen 231 organisms yielding suspicious colonies on stool differential agars for potential pathogens. All 54 salmonellae yielded correct screens. Of 14 shigellas, 9 keyed as possible Shigella spp.-Yersinia enterocolitica-rare Salmonella spp. (SYS), and 5 (all Shigella sonnei) keyed as possible S. sonnei-Y. enterocolitica-Arizona spp. (SYA). Three Arizona strains were identified as probable Salmonella spp., two were identified as SYA, and one was identified as SYS. Seven Y. enterocolitica strains keyed as SYS, and two keyed as SYA; one strain was screened out as a nonpathogen. The two Aeromonas hydrophila strains keyed as SYA, and the two Plesiomonas shigelloides strains keyed as SYS. All 63 Proteus, Morganella, Providencia, and Pseudomonas aeruginosa strains were screened out as nonpathogens. Among 80 coliforms, 37 were screened as SYA, 32 were screened as SYS, and 11 were screened as nonpathogens. On the basis of the SST, 69/80 coliforms would have been tested further. However, only 1/88 potential pathogens would have been missed, and all Proteus, Morganella, Providencia, and P. aeruginosa strains would have been excluded. The capability of the SST (when combined with a rapid identification method) of providing same-day identification of potential stool pathogens must be weighed against its inability to effectively screen out coliforms. The cost of this method is equivalent to that of a three-tube conventional screening method. The suitability of the SST for individual laboratories must be predicated on the incidence of stool pathogens and commensals in the specific setting as well as on factors related to work flow, technologist acceptability, and turnaround time.
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PMID:Evaluation of a two-hour method for screening pathogens from stool specimens. 638 49

An antigen prepared with agar-grown Legionella pneumophila group 1 killed by 0.5% phenol and suspended in 0.5% yolk sac was examined for use in the indirect immunofluorescence test for legionellosis and compared with a heat-killed antigen. The serological results of the two antigens for single and paired sera agreed well. Morphological and staining characteristics were better for phenol-treated organisms. Electron microscopy observation showed an apparently well-preserved cell surface. The background antibody level among a healthy control population was very low (3.4% with titers of greater than or equal to 16). Sera of patients with gram-negative bacteria infections (Yersinia enterocolytica, Campylobacter jejuni, Salmonella typhimurium, Escherichia coli, Brucella melitensis, Pseudomonas aeruginosa, Mycoplasma pneumoniae, Coxiella burnetti, and Chlamydia psittaci) showed no cross-reactions with the phenol-killed antigen. The data suggest that phenol-killed antigen is sensitive and specific. This antigen is stable for at least 1 year.
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PMID:Comparison of phenol- and heat-killed antigens in the indirect immunofluorescence test for serodiagnosis of Legionella pneumophila group 1 infections. 638 81

A microculture technique, employing 96-well tissue culture plates in plastic bags, was used to test the effect of different gas atmospheres (vacuum, air, nitrogen, and carbon dioxide) on the growth of Escherichia coli, Bacillus macerans, Salmonella typhimurium. Candida albicans, Lactobacillus plantarum, Pseudomonas/Acinetobacter/moraxella-group, Brochothrix thermosphacta and Yersinia enterocolitica at 2, 6, and 20 degrees C. In general, carbon dioxide was the most effective inhibitor. The inhibition increased with decreasing temperature. Only the combination of carbon dioxide and 2 degrees C provided complete inhibition of Broch. thermosphacta and Y. enterocolitica.
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PMID:Microculture model studies on the effect of various gas atmospheres on microbial growth at different temperatures. 641 75

Two murine monoclonal antibodies of the IgG3 class have been isolated after immunization with Brucella abortus. An indirect immunofluorescence test was used to screen hybridoma supernatants and subsequently to determine the cross-reactivity of the monoclonal antibodies with other bacteria. One monoclonal antibody reacted with all the smooth Brucella biotypes tried and with Yersinia enterocolitica serogroup 0:9, though not with rough Br. ovis or with strains of Escherichia, Proteus, Salmonella, Pseudomonas, Francisella and Bordetella. The other monoclonal antibody displayed a high degree of specificity for brucellae carrying the A lipopolysaccharide-protein surface antigen. The implications for the diagnosis of brucellosis are discussed.
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PMID:A monoclonal antibody specific for the A antigen of Brucella spp. 643 72


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