Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q8NEX9 (reductase)
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Human Gene/Protein
reductase 26410
NADPH 3879
NADH 2579
Sep 1789
Mol 1637
microsomal 1497
HMG-CoA reductase 1494
cytochrome 1266
P450 1056
cytochrome P450 950
NAD 918
ferredoxin 891
NADP 850
cytochrome c 786
oxidoreductase 739
FAD 698
cytochrome P-450 664
Pseudomonas 617
ATP 590
catalase 580
superoxide dismutase 539
GSH 514
endoplasmic reticulum 511
thioredoxin 458
FMN 431
flavoprotein 429
polypeptide 407
membrane-bound 396
NADPH-cytochrome P-450 reductase 387
androgen receptor 381
peroxidase 372
insulin 371
NADP+ 365
cytochrome b5 359
glutathione peroxidase 321
glutathione reductase 305
aromatase 301
HDL 295
SDS 288
NMR 283
cytochrome b 271
EPR 258
LDL receptor 252
ubiquinone 238
nitric oxide synthase 235
HSD 225
fused 223
ADP 222
ATPase 218
NAD+ 206
CPR 200
DT-diaphorase 199
hemoglobin 193
calmodulin 186
xenobiotic 184
alcohol dehydrogenase 176
ribonucleotide reductase 174
Gen 172
thioredoxin reductase 172
methemoglobin 171
aldo-keto reductase 169
SOD 168
fatty acid synthase 166
lactate dehydrogenase 164
glutathione S-transferase 163
dimeric 158
AMP 144
dihydrofolate reductase 144
GSNOR 140
HSD1 139
CO2 135
alkaline phosphatase 129
glucose-6-phosphate dehydrogenase 129
Prx 129
delta 4 128
Smith-Lemli-Opitz syndrome 126
cytokine 124
ACP 124
CYP3A4 119
cytochrome c oxidase 118
more...
Disease
cancer 1023
tumor 578
hypercholesterolemia 519
GSH 514
atherosclerosis 488
prostate cancer 379
diabetes 361
Mycobacterium 341
tuberculosis 305
SDS 288
cardiovascular disease 278
hyperlipidemia 233
hypertension 204
hepatocellular carcinoma 196
carcinogenesis 190
coronary heart disease 189
coronary artery disease 184
obesity 166
breast cancer 165
Steroids 162
stroke 155
Alzheimer's disease 155
carcinoma 149
dyslipidemia 138
myopathy 135
cold 131
Smith-Lemli-Opitz syndrome 129
ACP 124
plaque 120
ischemia 114
myocardial infarction 103
pheochromocytoma 102
hyperhomocysteinemia 102
PCC 99
leukemia 88
depression 87
tumor growth 86
type 2 diabetes 86
epididymis 84
external genitalia 83
malaria 77
methemoglobinemia 73
mole 72
mole 72
metabolic syndrome 71
Klebsiella 70
dehydration 69
SEM 67
neuroblastoma 65
MCF 64
seminal vesicles 64
adenocarcinoma 62
fatty liver 61
iron deficiency 58
renal disease 57
hyperglycemia 57
tumorigenesis 57
vascular disease 55
FAS 52
colorectal cancer 52
osteoporosis 51
lung cancer 51
heart failure 50
acne 50
Parkinson's disease 49
mental retardation 48
mental retardation 48
AGA 46
NAME 46
melanoma 45
gallstones 44
uterus 43
erectile dysfunction 43
multiple sclerosis 43
colon cancer 43
epilepsy 43
asthma 42
polycystic ovary syndrome 41
Chagas 41
PDB 40
more...
Symptom
starvation 117
masculinization 79
weakness 62
pain 54
seizures 51
cyanosis 41
myalgia 36
headache 27
fatigue 25
anesthesia 25
hyperoxia 21
diarrhea 19
agitation 15
collapse 15
acidity 15
Lower urinary tract symptoms 14
exhaustion 14
hepatomegaly 13
hypotonia 13
tremor 12
overweight 10
nausea 10
ataxia 10
thinning 9
HSA 9
prostatism 9
flushing 8
abdominal pain 8
respiratory distress 7
dysuria 7
angina 7
anorexia 7
hypothermia 6
analgesia 6
constipation 6
insomnia 6
urinary frequency 6
vomiting 5
Acute urinary retention 5
cerebellar ataxia 5
dyspnea 5
lethargy 5
ophthalmoplegia 5
spasticity 5
Wind 4
paraparesis 4
chest pain 4
shortness of breath 4
dystonia 4
splenomegaly 4
Ill 4
dizziness 4
abdominal discomfort 4
hemiplegia 3
discomfort 3
chills 3
hot flashes 3
nocturnal polyuria 3
acute stress 3
syncope 3
dysarthria 3
bloating 3
Anoxia 3
pelvic pain 3
discomfort 3
functional recovery 3
Decreased activity 3
erythema 3
hemoptysis 2
incoordination 2
cachexia 2
disturbed balance 2
ENT 2
abnormal gait 2
muscle stiffness 2
neurological disability 2
pallor 2
scaly skin 2
arthralgia 2
cough 2
more...
Drug
NADH 2548
FAD 698
THF 412
ascorbate 327
Simvastatin 260
lysine 242
Lovastatin 222
DHT 191
DHT 191
Pravastatin 184
Finasteride 182
vitamin E 120
Cardiovasc 116
Dermatol 110
MAP 99
ROS 97
Glutathione 79
Trypanothione 78
Gel 65
Kenyan 63
niacin 55
Leaf 54
Asn 53
Dihydrotestosterone 48
Heme 48
CDP 45
Rosuvastatin 45
CPR 43
Triclosan 43
Nitric Oxide 36
Dutasteride 35
Vitamin K 32
Ethanol 32
BH4 29
EE2 27
IFN-gamma 26
nitroglycerin 24
citric acid 24
pyridoxal phosphate 23
lactose 22
Isoniazid 21
Flavin 21
Mevastatin 19
Adriamycin 18
caffeine 18
Vitamin E 18
Estrogens 17
Ketoconazole 17
IL-2 16
CS-514 16
Gemfibrozil 16
NBT 16
ABC 15
ALA 15
Bifidobacterium 14
Cibacron Blue 14
Riboflavin 14
MK-733 14
NH3 14
Digitalis 14
Glycerol 13
Lipitor 13
-deoxyadenosine 13
Lipitor 13
Indomethacin 13
Angiotensin II 12
ICI 12
Nephron 12
Arsenic trioxide 12
Ezetimibe 12
DNase I 12
Monit 12
HCG 11
R1881 11
EPA 11
Pregnenolone 11
Carbenoxolone 11
all-trans-retinol 10
Mutagen 10
Capsicum 10
more...
Enzyme
CPR 699
catalase 619
superoxide dismutase 596
diaphorase 511
peroxidase 406
NQO1 367
glutathione peroxidase 339
glutathione reductase 318
nitrate reductase 299
alcohol dehydrogenase 294
nitrate reductase 293
nitrate reductase 293
nitrate reductase 291
nitrate reductase 289
nitrate reductase 289
complex I 281
ATPase 279
nitrite reductase 269
nitrite reductase 266
demethylase 265
nitrite reductase 257
succinate dehydrogenase 250
HSD 242
nitrogenase 235
glutathione S-transferase 234
aldose reductase 206
3-hydroxy-3-methylglutaryl-CoA reductase 201
ribonucleotide reductase 197
xylitol dehydrogenase 193
peroxiredoxin 189
xylitol dehydrogenase 189
11beta-hydroxysteroid dehydrogenase 186
NADPH-diaphorase 182
thioredoxin reductase 177
ribonucleotide reductase 177
lactate dehydrogenase 176
glucose-6-phosphate dehydrogenase 168
NADH-cytochrome b5 reductase 166
dihydrofolate reductase 161
adrenodoxin reductase 157
diaphorase 157
NO synthase 153
3-hydroxy-3-methylglutaryl coenzyme A reductase 148
chalcone synthase 143
mitogen-activated protein kinase 142
trypsin 138
cytochrome oxidase 135
alkaline phosphatase 130
NADPH oxidase 129
CYP3A4 119
cholesterol acyltransferase 119
NADPH oxidase 118
luciferase 117
hydrogenase 117
NADH dehydrogenase 116
hydrogenase 116
succinic dehydrogenase 114
aldehyde reductase 111
aldehyde reductase 109
protein kinase 108
ACS 107
aldehyde reductase 104
creatine kinase 104
aldehyde dehydrogenase 99
carbonyl reductase 97
acid phosphatase 94
xanthine oxidase 87
farnesyltransferase 83
formate dehydrogenase 82
aryl hydrocarbon hydroxylase 81
ERK 81
alanine aminotransferase 81
nitrous oxide reductase 79
AMP-activated protein kinase 78
heme oxygenase 77
methionine synthase 77
formate dehydrogenase 76
formate dehydrogenase 76
aspartate aminotransferase 76
flavin reductase 75
more...
Compound
NADPH 3885
NADPH 3882
NADH 2548
oxygen 2015
Dec 1946
DNA 1694
CoA 1519
iron 1450
NADP 1242
NAD 1102
nitric oxide 1004
HMG-CoA 979
phosphate 970
hydrogen 922
NAD 918
glucose 917
water 858
Clin 780
sodium 770
nitrogen 746
sulfate 725
acetate 723
FAD 700
cysteine 663
nitrate 650
ATP 591
GSH 565
GSH 565
nicotinamide 526
arginine 454
ethanol 449
FMN 448
xylose 448
methionine 430
His 411
copper 393
ammonium 349
lysine 349
CO2 342
aldehyde 338
methane 326
calcium 325
hydroxide 315
SDS 312
tyrosine 311
salt 310
aldehyde 298
H2O2 285
Cholesterol 263
galactose 260
alanine 258
glycerol 255
molybdenum 253
ubiquinone 253
pyridine 251
DHT 237
ADP 236
homocysteine 231
ADP 225
DMSO 223
ADP 222
glutamate 220
zinc 214
glutaryl-CoA 212
serine 198
pentose 184
alcohol dehydrogenase 182
Phe 181
NH2 181
ammonia 177
Cardiol 176
DEAE 175
androstane 174
GSSG 171
aniline 166
potassium 165
cyanide 154
AMP 154
Lovastatin 154
Atorvastatin 152
more...