Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:Q8NET8 (
TrpV3
)
5
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Temperature-sensitive transient receptor potential (TRP) channels such as TRPA1 and TRPV1 have been identified as downstream ion channel targets in the transduction of
itch
. As a member of the temperature-sensitive TRP family, the Ca
2+
-permeable nonselective
cation channel TRPV3
is expressed abundantly in skin keratinocytes. Recent identification of gain-of-function mutations of human TRPV3 from patients with Olmsted syndrome, which is characterized by severe
itching
and palmoplantar and periorificial keratoderma, unveils its crucial role in chronic
itch
and skin diseases. In this review, we will focus on recent progress made in the understanding of TRPV3 that emerges as an attractive target for developing effective antipruritic therapy for chronic
itch
or skin-related diseases.
...
PMID:The Ca
2+
-Permeable Cation Transient Receptor Potential TRPV3 Channel: An Emerging Pivotal Target for Itch and Skin Diseases. 2837 24
