Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:Q8IYM1 (
SEPT12
)
19
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Septins are a family of filament-forming GTP-binding proteins involved in a variety of cellular process such as cytokinesis, exocytosis, and membrane dynamics. Here we report the biochemical and immunocytochemical characterization of a recently identified mammalian septin,
SEPT12
.
SEPT12
binds GTP in vitro, and a mutation (Gly56 to
Asn
) in the GTP-binding motif abolished binding. Immunocytochemical analysis revealed that wild-type
SEPT12
formed filamentous structures when transiently expressed in Hela cells whereas SEPT12G56A generated large aggregates. In addition, wild-type
SEPT12
failed to form filaments when coexpressed with SEPT12G56A. We also observed that GTP-binding by
SEPT12
is required for interaction with SEPT11 but not with itself.
...
PMID:GTP binding is required for SEPT12 to form filaments and to interact with SEPT11. 1844 21
