Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q8IXL6 (RNS)
 1,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to analyse the peripheral disturbances repetitive stimulation test (RNS Test) and nerve conduction studies were done in 33 patients, 19 women and 14 men (mean age 38.2 years), with at least probable diagnosis of multiple sclerosis. In RNS Test the mean CMAP amplitude was significantly lower in comparison to the control group without any difference after 30 seconds of effort. Significant decrementing response was revealed at low rate of stimulation (2Hz) and incrementing response during tetanic stimulation. Significant lower mean amplitude of M wave in all investigated nerves was found in motor nerve conduction velocity test. Abnormal mean distal latency and motor conduction velocity were less common. The mean results of sensory conduction velocity test were similar to the control group.
Neurol Neurochir Pol
PMID:[Electrophysiological analysis of changes in peripheral nervous system in multiple sclerosis]. 1039 24

Reactive oxygen and nitrogen species (ROS and RNS respectively) play an important role in the proper functioning of many cellular processes. Generation of reactive oxygen species is an integral part of aerobic metabolism of cells. Their overproduction and subsequent oxidative stress occurs during pathogenesis of many diseases. Nitrosative stress is very closely linked to oxidative stress. Nitric oxide (NO), can react with molecular oxygen, superoxide anions and metal cations generating consecutive reactive oxygen species. These highly reactive chemical compounds react with proteins impairing their function by oxidation, or nitrosylation of amino acid residues, which may induce apoptosis. Furthermore, nitric oxide enhances the effect induced by cyclooxygenases and becomes a mediator of the inflammatory response. This paper gathers key information on the reactive oxygen and nitrogen species as well as processes in which they participate.
Pol Merkur Lekarski 2011 Nov
PMID:[Reactive oxygen and nitrogen species]. 2229 36

Beta-glucans participate in the processes of repair, metabolism and detoxification, and affect the overall health of the body counteract the pathological conditions of reactive oxygen and nitrogen and the processes in which they participate. Reactive oxygen species (ROS) and nitrogen (RNS) play an important role in the pathogenesis of many diseases. Production of ROS is an integral part of aerobic metabolism of cells. Physiological concentrations of ROS play an important role in proper functioning of many cellular processes, and their overproduction occurs during induced oxidative stress. Very closely associated with oxidative stress is nitrosative stress. Nitric oxide (NO) reacts with molecular oxygen, superoxide anion radical and metal cations to give more reactive oxygen species. Reactive oxygen and nitrogen react with proteins to cause impairment of their function by oxidation or nitrosylation of amino acid residues, which can direct the path of apoptotic cells. In addition, nitric oxide enhances the effect induced by cyclooxygenase and becomes a mediator of inflammation.
Pol Merkur Lekarski 2012 Oct
PMID:[Beta-glucan as a natural anticancer agent]. 2327 10