Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:Q8IXL6 (
RNS
)
1,091
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The integrity of the genome is threatened by DNA damaging events such as radiation, viral infection and chemicals. Ionizing irradiation is known to cause genotoxic damage through the generation of reactive oxygen species (ROS) and nitrogen species (
RNS
) and we have found that a signaling pathway for the nuclear translocation of
Translin
is initiated in association and efficiently blocked by a specific inhibitor of nitric oxide synthase (NOS). This suggests the involvement of inducible nitric oxide synthase (iNOS)-derived nitric oxide (NO) in the nuclear translocation of
Translin
. To address the functional significance of
Translin
in the hematopoietic generation system after ionizing irradiation, we generated
Translin
-deficient (
Translin
(-/-)) mice and examined hematopoietic colony formation after sublethal ionizing irradiation. We thereby confirmed a severe delay of colony formation in the spleens of
Translin
(-/-) as compared with
Translin
(+/+) mice. Taken together, the results suggest that
Translin
contributes to hematopoietic regeneration by acting as a sensor protein for radiation-induced damage.
...
PMID:Contribution of Translin to hematopoietic regeneration after sublethal ionizing irradiation. 1823 74
