Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:Q8IXL6 (
RNS
)
1,091
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Fibrosis is characterized by excessive accumulation of extracellular matrix (ECM) in basement membranes and interstitial tissues, resulting from increased synthesis or decreased degradation of ECM or both. The plasminogen activator/plasmin system plays an important role in ECM degradation, whereas the
plasminogen activator inhibitor 1
(
PAI-1
) is a physiologic inhibitor of plasminogen activators.
PAI-1
expression is increased in the lung fibrotic diseases and in experimental fibrosis models. The deletion of the
PAI-1
gene reduces, whereas the overexpression of
PAI-1
enhances, the susceptibility of animals to lung fibrosis induced by different stimuli, indicating an important role of
PAI-1
in the development of lung fibrosis. Many growth factors, including transforming growth factor beta (TGF-beta) and tumor necrosis factor alpha (TNF-alpha), as well as other chemicals/agents, induce
PAI-1
expression in cultured cells and in vivo. Reactive oxygen and nitrogen species (ROS/
RNS
) have been shown to mediate the induction of
PAI-1
by many of these stimuli. This review summarizes some recent findings that help us to understand the role of
PAI-1
in the development of lung fibrosis and ROS/
RNS
in the regulation of
PAI-1
expression during fibrogenesis.
...
PMID:Oxidative stress, plasminogen activator inhibitor 1, and lung fibrosis. 1797 97
