Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:Q8IXL6 (
RNS
)
1,091
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
ROS and
RNS
are important mediators of signaling pathways in the endothelium. Specific members of the
TRP
superfamily of cation channels act as important Ca
2+
influx pathways in endothelial cells and are involved in endothelium-dependent vasodilation, regulation of barrier permeability, and angiogenesis. ROS and
RNS
can modulate the activity of certain
TRP
channels mainly by modifying specific cysteine residues or by stimulating the production of second messengers. In this review, we highlight the recent literature describing redox regulation of
TRP
channel activity in endothelial cells as well as the physiological importance of these pathways and implication for cardiovascular diseases.
...
PMID:Redox regulation of transient receptor potential channels in the endothelium. 2780 96
