Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q8IXL6 (RNS)
 1,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Nitric oxide is one of the most important signaling molecule of living organisms. It may be produced by two ways: from arginine by means of NO-syntases and from nitrite by means of nitrite reductases. The last way is realized mostly at hypoxic state of organisms and heme-containing globins of vertebrates (hemoglobin, myoglobin, cytoglobin, neuroglobin) mediate the transformation of NO2 into NO by means of their nitrite reductase activities. Hypoxic NO-signaling depends on oxygen concentration and is important for exercise, vascular hypoxic vasodilation, myocardial preconditioning and angiogenesis. Data of scientific literature of last 15 years show that the nitrite-reductase activity of heme-containing globins was used for oxygen sensing and ROS/RNS defence at early stages of life evolution.
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PMID:[THE ROLE OF HEME-CONTAINING GLOBINS IN HYPOXIC NO-SIGNALING OF VERTEBRATE CELLS]. 2659 67