Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q86TM3 (cage)
 29,987 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A low-molecular-weight acceptor of galactosyltransferase activity was detected in sera and effusions of patients with extensive maligant disease. This substance was purified to homogeneity from both human serum and effusion by using sequential charcoal/Celite and DEAE-cellulose column chromatography. The purified acceptor was shown to act as substrate for both purified normal and cancer-associated human galactosyltransferase (EC 2.4.1.22) isoenzymes, but had a higher affinity for the cancer-associated isoenzyme (Km = 20 microM) than for the normal isoenzyme (Km = 500 microM). The substrate was found to be a glycopeptide with mol.wt. approx. 3600 determined by polyacrylamide-gel chromatography. Carbohyydate analysis demonstrated only the presence of glucosamine and mannose. Amino acid analysis revealed that the peptide moiety consisted of eight different amino acids, including two residues of asparagine and one residue of serine, but no threonine. These structural data suggest that the acceptor is a fraction of an asparagine-glucosamine type of glycoprotein.
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PMID:Detection, purification and characterization of a human cancer-associated galactosyltransferase acceptor. 8 90

The home-cage activity of mice housed in either social or enriched sensory environments was continuously recorded for 23 days. During this period the mice were given daily injections of either strychnine, chlorpromazine, or saline. Both chlorpromazine and social rearing depressed home-cage activity. Strychnine also depressed activity, but only in the social group.
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PMID:Drug-modulated behavioural responses to environmental enrichment. 9 91

Qualitative and quantitative observations were made on two monkeys with unilateral or bilateral removals of areas 5 and 7 of Brodmann. The task was to return to the home cage in the light or in the dark. Both animals were slower in the dark, and also qualitatively abnormal in the light.
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PMID:Disturbance of cage-finding in the monkey. 10 48

Signals of the electrical activity of the specific atrioventricular conduction pathways were recorded with an unipolar lead to obtain an exact time reference. The amplifier used had special characteristics: high gain settings (up to 300,000), very low noise levels, and wide filter range (2 Hz - 1,600 Hz). The low amplitude of the signals under study, of the order of a microvolt, and the wide filter range of the amplifier necessitated placing the patient in a Faraday cage. The signals recorded on magnetic tape were treated by a system of analysis for signal treatment. The method of averaging was used to extract the signal from background noise especially that arising from somatic muscle. The amplitude of the Hisian signal was much larger than that usually obtained with other methods. The intervals were determined with precision of the order of 1 millisecond. Frequential analysis of the signals gave another representation of the information contained in the time signals. This new representation seems to give better discrimination of the different zones of activation of the specific atrioventricular conduction pathways.
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PMID:[Recording and data processing of electrical signals of the specific atrioventricular conduction pathways in man]. 10 83

A mobile-transport-squeeze cage for primates was constructed. The cage contained a clear plastic guillotine door, squeeze apparatus, ventilation holes and locking casters. The squeeze apparatus could be operated by one person.
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PMID:A versatile primate cage for a multiple use facility. 10 71

Ethologic analysis has been used to study the behavioural effects following injection of delta-aminolaevulinic acid (ALA) in mice. After a dose level of 1.6 mmol ALA/kg, male and female mice showed periods of immobility and scanned less frequently than saline-injected controls. Exploration of the cage was significantly reduced in frequency in treated males, many elements of social and sexual investigation were reduced in treated females, and no elements of aggression were seen in treated males. Gait was abnormal and movement lethargic in animals showing the greatest degree of immobility. Righting reflexes and the response to stimuli of noise and touch remained normal. After a dose level of 0.8 mmol ALA/kg, no significant behavioural effects were detectable.
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PMID:Effects of delta-aminolaevulinic acid administration on social behaviour in the laboratory mouse. 10 30

The dynamics of natural selection on a lethal fourth chromosome of Drosophila melanogaster was studied in replicated half-pint bottle and cage populations over 12 generations. Population numbers fluctuated widely in all populations, but there was no association between fluctuation in numbers and change in lethal frequency. In the bottle populations the lethal heterozygote frequency decreased to a low of 0.04 to 0.05 and then increased to 0.18 to 0.30, suggesting that the selection coefficients were not constant. In the cage populations heterozygote frequency decreased to about 0.35 to 0.40. In the cage populations the data suggest that the lethal chromosome is overdominant for both viability and fertility selection.
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PMID:Dynamics of natural selection on a lethal fourth chromosome of Drosophila. Twelve-generation study of experimental populations of D. melanogaster. 11 47

Maintaining isolation-reared adult female Macaca mulatta in a group enclosure resulted in rapid resocialization. The influence of cerebellar lesions on social behaviors was most marked on aggressive interactions and cage stereotype pacing and circling.
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PMID:Behavioral interaction in social-deprivation-reared Macaca mulatta: effects of cerebellar lesions on aggressive and afiliative behaviors. 11 35

The effects of morphine (5, 10, 100, and 150 mg/kg SC) on locomotor activity, object manipulation, grooming, rearing, and responsiveness to social stimulation were observed in naive, nontolerant mice. Morphine induced significant changes in the behavior elements recorded. Five and 10 mg/kg morphine caused an initial phase of about 1 h with inhibition of all activities. After 1 h the mice gradually increased activity and exceeded the corresponding placebo level at the end of the sessions. 100 and 150 mg/kg morphine caused an increase in locomotor activity. This hyperactive continuous running was stereotyped, restricted as it was to only a certain part of the experimental cage. Concurrently all other behavior elements were abolished. The animals did not normalize within the observation period. Neither the sedated mice with low doses nor the mice with high doses of morphine responded socially to the presence of another untreated mouse which was placed in the cage as a social response test.
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PMID:Behavioral effects of low and high acute doses of morphine in solitary mice. 11 35

In this study, we placed unilateral utricular nerve section and measured the locomotor equilibrium function (deviation counts of the animal's trotting gait) by the squirrel monkey platform runway test. We applied physical exercise, both preoperatively (3 weeks) and postoperatively. 21 young adult squirrel monkeys were randomly assigned to three groups (7 each): rotating cage exercise (continuous trotting in the motor-driven rotating cage) group, rail-traversing exercise (60 running shuttles on the rotating rail) group, and control nonexercise group. After the statistical analyses on data it was found that the physical exercise showed some effect; however, the type, daily amount, and number of days applied must be quite substantial.
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PMID:Effect of exercise upon locomotor balance modification after peripheral vestibular lesions (unilateral utricular neurotomy) in squirrel monkeys. 11 1


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