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Query: UNIPROT:Q86TM3 (cage)
 29,987 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We evaluated the effect of global inspiratory muscle fatigue (GF) on respiratory muscle control during exercise at 30%, 60%, and 90% of maximal power output in normal subjects. Fatigue was induced by breathing against a high inspiratory resistance until exhaustion. Respiratory pressures, breathing pattern, and perceived breathlessness were measured. Induction of GF had no effect on the ventilatory parameters during mild and moderate exercise. It altered, however, ventilatory response to heavy exercise by increasing breathing frequency and minute ventilation, with minor changes in tidal volume. This was accompanied by an increase in perceived breathlessness. GF significantly increased both the tonic and phasic activities of abdominal muscles that allowed 1) the diaphragm to maintain its function while developing less pressure, 2) the same tidal volume with lesser shortening of the rib cage inspiratory muscles, and 3) relaxation of the abdominal muscles to contribute to lung inflation. The increased work performed by the abdominal muscles may, however, lead to a reduction in their strength. GF may impair exercise performance in some healthy subjects that is probably not related to excessive breathlessness or other ventilatory factors. The respiratory system is remarkably adaptable in maintaining ventilation during exercise even with impaired inspiratory muscle contractility.
Pneumonol Alergol Pol 1996
PMID:[Effect of respiratory muscle fatigue on their function during exercise]. 899 54

Idiopathic scoliosis is a triplanar deformity associated with a rib hump. The quantitative assessment of the principal elements of spinal and rib cage deformity based on the chosen parameters measured on a-p radiographs and CT scans was done in a group of 89 children with idiopathic scoliosis. The average Cobb angle was 63 degrees. In regression and correlation analysis the statistically significant correlation among spinal lateral curve, axial rotation and kyphosis/lordosis index was found. Significant correlation between the elements of spinal deformity and the size of the rib hump were also found. The rib cage may play an important role in the pathogenesis of idiopathic scoliosis.
Chir Narzadow Ruchu Ortop Pol 1997
PMID:[Pathomechanics of spinal and rib cage deformity in idiopathic scoliosis]. 937 67

Two cases of cervical discopathy operated on with anterior interbody fusion with the BAK-cage are described. The authors stress the advantages of this kind of stabilization: shorter time of the operation, no bone graft complication, immediate stabilization without collar. The technical procedures of BAK-cage implantation, indications and exclusion criteria are discussed.
Neurol Neurochir Pol
PMID:[Anterior interbody fusion of cervical spine with BAK-C: case reports]. 1096 29

The selectively bred alcohol-preferring and alcohol-non-preferring lines of rats have been used to study the biology of alcohol abuse and dependence. In our laboratory new lines of Wistar rats have been selectively outbread for 7 years and 19 generations for high and low ethanol intake (WHP--Warsaw High Preferring) and WLP--Warsaw Low Preferring respectively). After the first selection procedure, the highest scoring females and males were used initiate upward selection, while the lowest scoring pairs were used to initiate downward selection. Mated pairs were housed in breeding cages, pups were allowed to nurse for 3 weeks before weaning, then the pups of each litter were culled to the same-sex cage and allowed to mature until they were subjected to the selection procedure. In order to determine the alcohol intake and preference, the rats were individually housed in wire cages containing two graduated drinking tubes mounted at the front. During the entire investigation, the subjects had free access to standard lab chow (Bacutil, Poland). Ethanol solution was prepared from 95% stock ethanol and tap water. The animals were presented with 10% ethanol solution and water (two-bottle choice test). The drinking tubes were rotated daily to prevent position preference. Alcohol intake was calculated as average g/kg/day (absolute ethanol) while alcohol preference (in %) was calculated as the amount of alcohol consumed/total fluid x 100. Our results (17-19 generations) have shown that mean alcohol intake in WHP rats was higher than 5.0 g/kg/24 h ethanol, while WLP rats generally consumed less than 2.0 g/kg/24 h ethanol. Our results also showed that the total fluid intake in WHP rats slightly but not significantly higher as compared with WLP rats. Maximal ethanol consumption (in both lines) occurred during the natural dark phase three bungs (19.00-20.00 hrs, 23.00-02.00 hrs and 04.00-05.00 hrs). Interestingly, the intakes of high concentrations of sucrose and saccharin solutions were significantly higher in WHP than in WLP rats. Furthermore, the WHP rats reduced their alcohol and water intakes in the presence of 10% sucrose solution. Thus, it appears that high consumption of sweets may be a neurobiological factor promoting increased ethanol intake by WHP rats.
Acta Pol Pharm 2000 Nov
PMID:Animal model of ethanol abuse: rats selectively bred for high and low voluntary alcohol intake. 1129 78

Two cases with cervical discopathy and radiculopathy are presented. Discectomy and anterior interbody fusion with cage-plate PCB manufactured by French company Scient'x was performed. Authors present the shape of the implant and technical details of implantation. The paper discusses the advantages of the PCB which simplifies and shortens the operation procedure, minimizes the risk of traditional bone graft harvesting and provides immediate stabilization of the operated segment.
Neurol Neurochir Pol
PMID:[Anterior interbody fusion of cervical spine with case-plate PCB]. 1198 12

A patient with an inverterate transpedicular fracture of atlas and C2/C3 subluxation, with stenosis of spinal canal by bone fragment, was operated using anterior retropharyngeal approach. Stabilization with interbody cage was performed. During follow up examination both clinical and radiological result was good. This surgical approach seems to be a comfortable approach to the upper cervical spine.
Chir Narzadow Ruchu Ortop Pol 2002
PMID:[Surgical treatment of old C2 spinal fracture with C2/C3 subluxation using an anterior retropharyngeal approach--case report]. 1223 5

Expiratory muscle recruitment is common in stable COPD patients. However, physiological significance of expiratory muscle recruitment in COPD remains unclear. The purpose of this study was to assess the effect of expiratory muscle contraction on force generating ability of the diaphragm in COPD patients breathing at rest. The force generating ability of the diaphragm was evaluated from its pressure swing (Pdi) for a given diaphragm electrical activity (Edi), where Edi was normalized as % of its maximal value [Pdi/(Edi/Edimax)]. Phasic expiratory muscle contraction was measured as the total expiratory rise in gastric pressure (Pgaexp.rise). Nineteen patients with severe COPD, participated in the study but only 10 exhibited phasic rise in Pga during expiration with a mean Pgaexp.rise of 1.91 +/- 0.89 cmH2O. Patients were divided into passive expiration (PE) and active expiration (AE) groups. There was no significant difference in lung function and breathing pattern parameters between the two groups. Pdi/(Edi/Edimax) was 0.63 +/- 0.07 and 0.54 +/- 0.07 cm cmH2O/% in PE and AE groups, respectively, and was not significantly different between each other. Compared with PE group, AE group not only recruited expiratory muscles, but also preferentially recruited inspiratory rib cage muscles and derecruited the diaphragm. In conclusion phasic contraction of expiratory muscles at rest in COPD patients do not improve the force-generating ability of the diaphragm.
Pneumonol Alergol Pol 2002
PMID:[Role of expiratory muscles in COPD patients]. 1270 80

A definition of subsidence in terms of spinal biomechanics is presented in the paper. Subsidence is defined as sinking of a body with a higher elasticity modulus (e.g. graft, cage, spacer) in a body characterized by a lower elasticity modulus (e.g. vertebral body), resulting in 3D changes of the spinal geometry. Magnitude of subsidence is directly proportional to the load pressure and to the difference between the elasticity modules, but inversely proportional to the area of the graft-bed interface. Both biological and mechanical qualities of the graft-bed interface are important for the subsidence process. Any excessive subsidence decreases the interbody space and produces both local and general kyphotization of the spine. This may cause destabilization of the screw-plate and/or screw-bone interfaces (e.g. pulling-out, altered angulation or breakage of the screws). A method is proposed of radiological estimating the absolute magnitude of subsidence, based on the real known length of the implanted stabilizer (e.g. plate). Clinical examples of an excessive subsidence and its impact on the stabilizing plate system are presented. Subsidence is inherent in the interbody fusion process. Endplate preservation and a dynamic modification of cervical plates may enables us to control subsidence and reduce the number of complications.
Neurol Neurochir Pol 2003
PMID:[Subsidence and its effect on the anterior plate stabilization in the course of cervical spondylodesis. Part I: definition and review of literature]. 1474 48

Chronic unpredictable stress (CUS) is one of the behavioral models resembling in some respects (loss of normal aggresiveness) human depression. In the present study, consistent with the ethical principles for scientific experiments on animals, we have decided to modify the CUS procedure. In this new modified model named chronic unpredictable mild stress (CUMS), we have introduced mild stressor (14 h period of 45 degrees cage tilt) instead of one severe stressor (20 s exposure to electric footshock). The purpose of the present study was to determine whether this new procedure CUMS, similarly to CUS, affected the footshock-induced fighting behavior. We have also investigated the effect of antidepressant drugs with different pharmacological profiles (imipramine, mianserin, fluoxetine, moclobemide, tianeptine) and anxiolytic drug (oxazepam) on fighting behavior in rats submitted to CUMS. It was found that in rats subjected to CUMS procedure the number of fighting attacks was significantly reduced (by about 80%). Prolonged treatment (once daily, for 14 days) with imipramine (10 mg/kg/day), tianeptine (12.5 mg/kg/day), mianserin (10 mg/kg/day), moclobemide (50 mg/kg/day), fluoxetine (10 mg/kg/day), but not oxazepam (5 mg/kg/day) prevented the deficit in fighting behavior in rats subjected to CUMS. In conclusion, the results of the present study indicate that CUMS, similarly to CUS procedure, induced behavioral deficit in rats which was normalized by antidepressants with a different pharmacological profile.
Pol J Pharmacol
PMID:Antidepressants in chronic unpredictable mild stress (CUMS)-induced deficit of fighting behavior. 1521 60

The purpouse of this study was to compare results of anterior cervical decompression and fusion for cervical disc disease with 2 different interbody devices: titanium cylinder-design cage and carbon box-design cage. The results of operations of 46 patients (60 instrumented levels) divided in to groups according to implant type were examined to asses the restoration of disc height, clinical outcome, bony fusion and complication rate. In the cylinder-design cage group average postoperative restoration of disc height was 72% but with narrowing rate of 26% in follow up. In the carbon box group postoperative disc height restoration was 51% with narrowing in follow up to 6%. Clinical outcome was comparable in both groups and loss of disc height in cylinder-design cage group had no effect on clinical outcome. There were 2 cases of pseudoarthrosis in cylinder cage group. Overall the study shows better radiological outcome of carbon box-design cages in comparison to cylinder design cages with no influence on clinical effect.
Chir Narzadow Ruchu Ortop Pol 2005
PMID:[Assessment of radiological results of anterior cervical discectomy with different fusion cages]. 1661 67


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