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Query: UNIPROT:Q86TM3 (cage)
 29,987 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

2-months restriction of physical activity of dogs markedly reduced their capacity for prolonged running. The rate of exercise-induced Tre increases was significantly higher in the cage-confined dogs in comparison with controls. At the point of exhaustion blood glucose concentration and muscle glycogen content were similar in the control and cage-confined animals, in spite of the much shorter time of exercise until exhaustion in the latter. The exercise-induced increases in plasma FFA concentration were considerably lower in dogs after prolonged inactivity period in spite of the greater activation of the adrenergic system. It is concluded, that there are several factors which may contribute to the reduction of the ability of cage-confined dogs to perform prolonged physical exercise. The most important seems to be the diminished muscle glycogen content, modifications in exercise metabolism and exercise-induced hyperthermia.
Acta Physiol Pol
PMID:The effect of prolonged restriction of physical activity on exercise performance in dogs. 49 38

Eight-week restriction of physical activity markedly reduced the capacity for prolonged running. The rate of exercise-induced Tre increases was also significantly higher in comparison with control experiments. At the point of exhaustion blood glucose concentration and muscle glycogen content were similar in the control and cage-confined animals, however the rate of decrease in blood glucose level and muscle glycogen depletion during exercise were higher in the cage-confined dogs than in the controls.
Acta Physiol Pol
PMID:The effect of restriction of physical activity on adaptation to prolonged exercise in dogs. 127 12

Investigations were made of the action of ACTH and LH-RH on a number of behavioural paradigms and the possible involvement of neurotransmitters or opiates by pretreatment of receptor blockers in rats and mice. ACTH delayed the extinction of active avoidance behaviour. Atropine and haloperidol blocked this action, whereas phenoxybenzamine and propranolol were ineffective. LH-RH or a highly potent analogue of LH-RH (D-Trp6-LH-RH) decreased the rate of disappearance of dopamine in the hypothalamus following alpha-methyl- paratyrosine inhibition of catecholamine synthesis, and blocked the accumulation of serotonin following MAO inhibition. LH-RH or the analogue attenuated the consolidation of passive avoidance learning. Apomorphine-induced cage-climbing was also inhibited by the LH-RH analogue, but this action was not influenced by naloxone. Open-field activity (ambulation, rearing and grooming) was decreased by the analogue peptide. Naloxone blocked the action on ambulation and rearing, but was ineffective on grooming. The LH-RH analogue caused a dose-dependent increase in cataleptogenic activity. This action could not be blocked with naloxone. The LH-RH analogue suppressed picrotoxin-induced seizures. Naloxone restored the situation to the control level. The data suggested that the effects of some neurohormones are mediated by transmitters or endogenous opiates, and that both peptide-transmitter and peptide-peptide interactions have to be considered in the action of neurohormones.
Pol J Pharmacol Pharm
PMID:Involvement of neurotransmitter and neuropeptides in behavioural action of some neurohormones. 198 90

The subjects were 100 alcohol addicted persons and 117 non-addicted (according to CAGE criteria). The sociodemographic characterization of each person was done. The parameters of psychomotor performance were estimated: the simple reaction time task, the simple performance test, the tapping test and a visual-motoric coordination. The following conclusions were established: 1) the alcohol addiction makes the psychomotoric performance worse, 2) the CAGE test is proposed to be included as a routine method to qualify for a job demanding high psychomotor performance, 3) the persons suspected of alcohol addiction should be sent to the specialist +psychotechnical examinations, 4) the building trade workers are the high risk group for alcohol addiction.
Psychiatr Pol
PMID:[Evaluation of psychomotor performance of professionally active alcoholics]. 213 71

The relations between social functioning and severity of alcohol dependence of 40 male patients from Dependence Treatment Ward in Bydgoszcz were studied. Using the MAST, CAGE, and self clinical scale the cohort was divided into two groups: less and more severe dependent probands. The demographic and social data of patients from both groups did not differ significantly. Social functiong was evaluated by use the Scale of Social Roles taking into consideration the set of marital roles (with basic roles of sexual partner, friend, guardian, and family support). The disposition to perform the role, privileges, fulfilling the duties, activity, and harmonization of the role were estimated in each of the role mentioned above and in every patient. It was shown that subjects more dependent on alcohol are significantly less active in the role of sexual partner and in support of family, as well as are less effective in performing such roles and are more egoistic in the role of sexual partner than men less dependent on alcohol. No differences were found in other roles among studied groups. The revealed differences were discussed in the aspect of psychologica and interactive hanges in marital couple.
Psychiatr Pol
PMID:[Severity of alcohol dependence and social functioning of male patients with alcoholism. I. Functioning in the sharing of marital roles]. 263 Nov 27

The relations between social functioning and severity of alcohol dependence of 40 male patients from Dependence Treatment Ward in Bydgoszcz were studied. Using the MAST, CAGE, and self clinical scale the cohort was divided into two groups: less and more severe dependent probands. The demographic and social data of patients from both groups did not differ significantly. Social functioning was evaluated by use the Scale of Social Roles taking into consideration the set of basic roles: role of guardian, family support, educator, superior, subordinate, member of social group, patient, and the role of child. The dispositions to perform the role, privileges, fulfilling the duties, activity, and harmonization of the role were estimated in each of the role mentioned above and in every patient. It was shown that subjects more dependent on alcohol are significantly less active in the role of family support, educator, subordinate, and they possess significantly less dispositions to the role of educator and superior. No differences were shown between the groups regarding other characteristics of each role. The comparison of joint structural elements of the whole set of roles among more dependent patients showed deficits of social functioning as follow: the impairment of dispositions and fulfilling of duties as well as lesser activity, in comparison with less dependent probands. The level of privileges obtained from the roles did not differ in both groups. The specific influence of alcohol dependence severity on the way of social functioning demonstrated in the study may show the directions of therapy.
Psychiatr Pol
PMID:[Severity of alcohol dependence and social functioning of male patients with alcoholism. II. Functioning in parental, employee's and autonomous roles]. 263 Nov 28

Male Wistar rats were given orally for seven days water, clonidine (0.125 or 0.25 mg/kg bid) or S3341, a new clonidine-like drug (2.5 or 5.0 mg/kg bid) and afterwards pairs of rats were injected ip with 2.5 mg/kg of apomorphine (APO). Water-treated animals did not behave aggressively. Clonidine and S3341 both induced clear aggression when combined with a subthreshold dose of APO. Some degree of hyperirritability developed in these two groups during drug treatment when observed in the home-cage. No significant changes in aggressive behavior were noted upon acute administration of both drugs, though some tendency to augment aggressivity could be observed after clonidine (0.25 mg/kg po). It is suggested that noradrenergic neurons play an inhibitory role in APO-induced fighting.
Pol J Pharmacol Pharm
PMID:Enhanced apomorphine-induced fighting in rats after prolonged oral treatment with drugs altering noradrenergic transmission. 282 37

The aim of the present study was to examine an effect of cold exposure on the concentration of triglycerides (TG) in the rat's liver. The rats were divided into the following groups: control, fed with oil, treated with hydrocortisone, fed with oil and treated with hydrocortisone, treated with noradrenaline. The rats exposed to cold were kept in wire cages (one rat in one cage) in the cold room at temperature +2 degrees C. They had free access to food (pellet diet for rodents) and water. In the control group the exposure to cold increased mildly (though significantly) the TG concentration after 1 and 3 h and had no effect after 2 and 24 h. It did not affect the concentration of plasma free fatty acids (FFA). At room temperature feeding with oil (2 ml/100 g of body weight) alone, and combined with hydrocortisone treatment (5 mg/100 g of body weight) as well as treatment with noradrenaline (0.1 mg/100 g of body weight) had no effect on the liver TG concentration, although the concentration of plasma FFA was increased. Exposure to cold for 3 h increased markedly the liver TG concentration in each of those groups. It is concluded that exposure to cold elicits a mechanism, which in the presence of elevated plasma FFA concentration induces accumulation of TG in the liver.
Acta Physiol Pol
PMID:Effect of cold exposure on the concentration of triglyceride in the liver of the rat. 321 50

The effect of encouraging to ingestive behavior was examined in cats pretreated with amphetamine (AMPH) in a dose sufficient for evoking anorexia (2 mg/kg). AMPH evoked complete refusing of spontaneous food ingestion in all animals. However, the cats could eat in even frantic manner when they were encouraged to ingestive behavior by moving the bowl with food around the place where the animal was sitting in the experimental cage. This result reveals that so called "anorexic syndrome" does not consist simply in a loss of appetite. It may be temporarily suppressed by some additional external stimuli which enable to channel the animal's behavior to the ingestive one.
Acta Physiol Pol
PMID:Amphetamine anorexia in cats: the effect of encouraging to ingestive behavior. 387 Jan 52

We examined the control of respiratory muscles with emphasis on the diaphragm during exercise at 30%, 60% and 90% of maximal working capacity in normal subjects. Control of the diaphragm was quantified by plotting transdiaphragmatic pressure (Pdi), its electromyographic activity (Edi) and its power (Wdi = Pdi x Dab/Ti) vs. workload and Pdi, an index of shortening velocity of diaphragmatic fibres (Dab/Ti) and Wdi vs. Edi. We observed that increase in Pdi (approximately 2-fold) from rest to heavy exercise was inadequately small comparing to increases in minute ventilation (approximately 9-fold) and Edi (approximately 4.5-fold). We hypothesized and confirmed that Wdi might increase even though Pdi decreased due to increasing Dab/Ti and expresses more closely diaphragmatic contribution to inspiratory effort during exercise than Pdi. Significantly augmented shortening velocity of the diaphragm suggests that it acts predominantly as a flow generator during exercise. It is strongly assisted in this task by abdominal muscles. The responsibility for generating inspiratory pressures falls on the inspiratory rib cage muscles. This arrangement may however impair diaphragm's performance even in healthy subjects as indicated by reduced Pdi twitch after exercise.
Pneumonol Alergol Pol 1996
PMID:[Function of the diaphragm during exercise]. 899 53


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