Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q86TM3 (cage)
 29,987 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Six critical tests with disophenol were conducted in July, 1978, in fur seal pups (Callorhinus ursinus) naturally-infected with adult hookworms, Uncinaria lucasi, and infested with various stages of two species of sucking lice, Proechinopthirus fluctus (Ferris) and Antarctophthirus callorhini (Osborn). Disophenol at a dose rate of 12.5 mg/kg was administered subcutaneously to each of six pups. Each pup was contained in an individual cage for 60 h posttreatment at which time pups were exmained at necropsy. Efficacy against hookworms ranged from 2% to 88% and of both species of lice ranged from 26% to 90% for the six pups. Disophenol removed approximately 90% of all adult lice but only slightly more than 60% of all nymphs. The only sign of toxicosis was a probable drug related fluid-like feces for four pups from 12 to 60 h posttreatment.
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PMID:Variable activity of disophenol against hookworms and lice of northern fur seal pups on St. Paul Island, Alaska. 737 24

Grooming is often related to dearousal following stressors. Interestingly, electrical and chemical stimulation of the paraventricular nucleus of the hypothalamus (PVH), at levels that are known to activate the hypothalamus-pituitary adrenal axis (HPA), also elicits grooming. At the level of the PVH, the neuroendocrine stress response is apparently still linked to the behavioural response to stressors. However the precise nature of this relation is not fully understood. Here we report on grooming in rats following exposure to different stressors which are known to activate the HPA axis. Stressors such as handling, restraint, novelty, encounters with aggressive or non-aggressive conspecifics, or moistening the fur, change the amount and time course of grooming upon return in the home cage, as compared with controls that are just handled. However, the amount of grooming is not directly related to the strength of the stressor. Defeated intruders groom less upon return in their home cage. Novelty and non-aggressive encounters with conspecifics reduce the variation in the amount of grooming between rats. The time course of grooming over the 20-min observation period also differs between treatments. Following restraint, or exposure to non-aggressive conspecifics, grooming first increases and then decreases. Moistened rats immediately start grooming which subsequently decreases. Rats used as intruders in the territory of another rat maintain a constant low level of grooming. Rats placed in a novel cage steadily increase grooming during the 20-min observation period. These results suggest that grooming cannot be simply understood as an immediate response necessary to reduce arousal following stressors. Following exposure to a stressor, grooming rather seems temporary suppressed.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Effect of environmental stressors on time course, variability and form of self-grooming in the rat: handling, social contact, defeat, novelty, restraint and fur moistening. 788 Apr 54

An experimental cage system was designed for evaluating the association of social status and reproductive performance in blue foxes under fur-farm conditions. The present test cage apparatus consisted of 6 small cages and 1 large cage that were connected. The small cages were utilized for males of different social status and the large cage for females coming on heat. The results showed that this type of testing apparatus can be used for evaluating a female's acceptance of males of different social rank. The locomotor activity of males significantly depended on their social status; thus the most active individuals in the test were the most dominant, and vice versa. Females most often accepted higher-ranking males. Juvenile males were the least dominant and also the least accepted by females. Urination activity was not necessarily related to dominance.
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PMID:Evaluation of the relationship between social status and reproductive performance in farmed blue foxes. 821 57

In group-housed laboratory mice whisker trimming (removal of vibrissae) occurs occasionally, but in the A2G strain it is seen almost invariably. We have tested the hypothesis that whisker trimming in A2G mice is not prevented by offering the possibility to withdraw from it. Pairs of male or female mice showing absence of whiskers and/or absence of nasal fur were separated by placing in their cage either one or two wire screens with a 10 mm mesh. Unlike the single screen, the two screens, which were 10 mm apart from each other, excluded nose to mouth contact. After five weeks, whiskers had regrown in mice separated by the double screen, whereas in the pairs separated by the single screen whiskers remained in part absent. This suggests that 2 mice involved in whisker trimming, either actively or passively, co-operate in this behaviour.
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PMID:Whisker trimming behaviour in A2G mice is not prevented by offering means of withdrawal from it. 836 73

Animals with partial alopecia were seen frequently in a breeding colony of guinea pigs. No pathologic aetiology could be determined. An influence of nutrition on the density of the hair coat was considered. Breeding groups were fed one of the commercial guinea pig diets of differing composition, with or without the addition of hay. Observation occurred over a period of months and the quality of the hair coat was evaluated periodically using a semi-quantitative scoring system. More extensive and more frequent fur defects were found is guinea pigs receiving a breeding diet with a high content of crude protein (23%) and a low level of crude fibre (12%), offered hay only restrictively compared with animals receiving a diet with a lower content of crude protein (15.5%) and a higher level of crude fibre (19.5%), offered the same amount of hay. The amount of hay offered is of paramount importance. Animals fed only the diet with the higher level of crude fibre (19.5%), according to the manufacturer's instructions as a complete food, without the addition of hay, showed a less dense hair coat within 4 weeks. In our colony a group of five breeding animals and their young required 200 g of hay daily in order to improve their hair coat quality to normal. Conversely, animals receiving less hay had progressively deteriorating hair coat density. Not only the amount of hay offered, but also the accessibility for all animals plays a role in preventing alopecia in guinea pigs. In larger cages (twice the usual ground surface area) fur defects were seen when the same amount of hay (200 g) was offered in only one central area, rather than spread out evenly throughout the cage. Hair loss was observed to be the result of trichophagia between adult animals kept in the same cage. The need for crude fibre of breeding animals does not appear to be completely met by pellets rich in fibre segments.
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PMID:Influence of feeding hay on the alopecia of breeding guinea pigs. 934 26

In the early 1920s, workers in both England and the US had discovered that rats on a rachitic diet would remain healthy if irradiated with ultraviolet light. However, they also found, to their surprise, that "control" rats too would recover if either their jar was irradiated without the rat in it or if a cage-mate was removed for irradiation and then returned. The ideas that either air or material objects that had been irradiated continued themselves to convey healthful secondary radiations were investigated but not confirmed. There was then the commercially important finding that with irradiation, some rachitic diets would become anti-rachitic. However, this effect did not explain all the previous findings. Consumption of either small irradiated fecal particles or of feces from irradiated rats was the likely explanation for the recovery of nonirradiated rats, but this was not tested by direct experiment, and it now appears unlikely that feces from irradiated rats would show significant antirachitic activity. It is suggested that an alternative possibility--activity of grease from irradiated fur--deserves investigation.
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PMID:Forgotten mysteries in the early history of vitamin D. 1072 Jan 80

Tetrodotoxin (10 pmol in 300 nl of Ringer), injected bilaterally into the region of the amygdala in conscious rabbits, virtually abolished the sudden falls in ear pinna blood flow that normally occur in response to salient environmental stimuli (touching the animal's fur, slightly moving its cage, or applying or removing a drape covering the cage). Time spent at 0-20% of maximum flow values during a 10 min observation period, commencing 15 min after injection of tetrodotoxin, significantly decreased compared with the pre-injection control period (30+/-14 s compared with 286+/-24 s, P<0.01, n=8 rabbits) and the time spent at 70-100% of maximum flow values significantly increased (521+/-36 s compared with 127+/-29 s, P<0.01). Vehicle was injected on the day before tetrodotoxin injections in four of eight rabbits and on the day after tetrodotoxin injections in the other four rabbits, in a counterbalanced design. Rabbits fully recovered from the effects of tetrodotoxin in one day. Vehicle did not significantly affect the time spent at different flow percentage values. Falls in ear blood flow elicited by noxious stimuli (ear pinch, inhalation of formaldehyde vapor) occurred in a normal pattern after tetrodotoxin. Amygdaloid circuitry is thus necessary for the production of falls in ear pinna blood flow that occur in response to unconditioned non-noxious stimuli, but not for the falls that occur in response to unconditioned noxious stimuli in rabbits. In humans, the amygdaloid region may also be involved in co-ordinating falls in cutaneous blood flow occurring in response to salient or anxiety-evoking stimuli. Thus, discovery of the neural pathways by which amygdaloid circuitry alters ear pinna blood flow in rabbits may elucidate the manner in which similar cardiovascular changes occur in humans during anxiety reactions.
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PMID:Amygdala co-ordinates sudden falls in ear pinna blood flow in response to unconditioned salient stimuli in conscious rabbits. 1043 Apr 78

Rigorous experimental design can minimize the high risk of false positives and false negatives in the behavioral phenotyping of a new transgenic or knockout mouse. Use of well established, quantitative, reproducible behavioral tasks, appropriate Ns, correct statistical methods, consideration of background genes contributed by the parental strains, and attention to litter and gender issues, will maximize meaningful comparisons of -/-, +/-, and +/+ genotypes. Strategies developed and used by our laboratory are described in this review. Preliminary observations evaluate general health and neurological reflexes. Sensory abilities and motor functions are extensively quantitated. Specific tests include observations of home cage behaviors, body weight, body temperature, appearance of the fur and whiskers, righting reflex, acoustic startle, eye blink, pupil constriction, vibrissae reflex, pinna reflex, Digiscan open field locomotion, rotarod motor coordination, hanging wire, footprint pathway, visual cliff, auditory threshold, pain threshold, and olfactory acuity. Hypothesis testing then focuses on at least three well-validated tasks within each relevant behavioral domain. Specific tests for mice are described herein for the domains of learning and memory, feeding, nociception, and behaviors relevant to discrete symptoms of human anxiety, depression, schizophrenia, and drug addiction. An example of our approach is illustrated in the behavioral phenotyping of C/EBPdelta knockout mice, which appear to be normal on general health, neurological reflexes, sensory and motor tasks, and the Morris water task, but show remarkably enhanced performance on contextual fear conditioning.
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PMID:Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests. 1044 92

We determined whether functional integrity of neurons in the amygdala is necessary for sudden episodes of cutaneous vasoconstriction that occur when the conscious animal detects a salient alerting stimulus. To inhibit neuronal function, muscimol (5 nmol in 300 nl), a long acting and potent GABA-A receptor agonist that hyperpolarizes neurons, was injected bilaterally into the amygdala or into a more dorsal control site in conscious rabbits. Cutaneous blood flow was measured in the ear pinna flow using an ultrasonic Doppler probe chronically implanted around the central ear artery. Ear flow responses to salient unconditioned alerting stimuli (fur touch, slight cage movement. removal of drape covering cage) were examined before and after injection of the muscimol, and the effects compared with effects of muscimol on the ear flow response to more nociceptive stimuli, including ear pinch. Muscimol injections into the dorsal control site did not significantly alter alerting-related episodes of ear pinna vasoconstriction. Muscimol injections into the amygdala almost completely abolished ear vasoconstriction elicited by fur touch (0/5 positive responses), drape removal (0/7 positive responses) and cage movement (0/7 positive responses). Muscimol injections into the amygdala reduced the mean ear flow coefficient of variation for a 15 min observation period from 47+/-5 before injection to 15+/-33% after injection (P<0.01, n=7 rabbits). Muscimol injections into the amygdala did not alter the vigorous ear pinna vasoconstriction elicited by ear pinch (7/7 positive responses). Our results indicate that neuronal function in the amygdala, probably the central nucleus of the amygdala, is necessary for the occurrence of ear pinna vasoconstriction episodes elicited by unconditioned salient stimuli but not for the occurrence of corresponding vasoconstriction elicited by nociceptive stimuli.
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PMID:Neurons in amygdala mediate ear pinna vasoconstriction elicited by unconditioned salient stimuli in conscious rabbits. 1147 84

A significant proportion of patients suffering from major clinical depression exhibit sudden bursts of anger often described as "panic attacks without anxiety or fear" or "irritability." We investigated aggressive behavior in mice from four different inbred strains subjected to unpredictable chronic mild stress (UCMS). Our results show that UCMS affects self-grooming behavior, as evaluated by the state of an animal's fur, with severity of symptoms differing according to genetic background. Furthermore, UCMS increased aggression both in a resident-intruder test and between cage-mates. UCMS is therefore a valuable model of the problematic aggressive behavior seen in depressive patients.
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PMID:Agonistic behavior and unpredictable chronic mild stress in mice. 1457 28


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