Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q86TM3 (cage)
 29,987 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Reactions of the pyridine N-oxide ligands L, L2 and L3 with the silver acetylenediide-containing system under hydrothermal conditions gave rise to four silver-acetylenediide complexes bearing interesting C2@Agn motifs: (Ag2C2)2(AgCF3CO2)8(L1)3.5 (1), (Ag2C2)2(AgCF3CO2)8(L2)2 (2), (Ag2C2)(AgCF3CO2)4(L3) (3) and [(Ag7(C2)(CF3SO3)3(L3)2(H2O)2] x 2CF3SO3 (4) (L = nicotinic acid N-oxide, L(1) = pyridine N-oxide, L2 = 1,2-bis(4-pyridyl)ethane N,N'-dioxide, L3 = 1,3-bis(4-pyridyl)propane N,N'-dioxide), which exhibit new distorted polyhedral C2@Agn cage motifs. Complex 1 has a pair of acetylenediide dianions encapsulated in a Ag(14) aggregate composed of three polyhedral parts, whereas 2 contains an irregular (C2)2@Ag13 double cage. In 3, the basic building unit is a centrosymmetric (C2)2@Ag12 double cage with each component single cage taking the shape of a highly distorted triangulated dodecahedron with one missing vertex. As to complex 4, the core is a C2@Ag7 single cage in the form of a slightly distorted monocapped trigonal prism with four cleaved edges that include all three vertical sides. Furthermore, in the silver-rich environment, the pyO-type ligands are induced to exhibit unprecedented coordination modes, such as the mu(5)-O,O,O,O',O' ligation mode of L2 in 2 and the mu4-O,O,O',O' mode of L3 in 3 and 4.
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PMID:Polyhedral C2@Agn cages distorted by ancillary pyridine N-oxide ligands in silver-acetylenediide complexes. 1678 73

The reaction of MeAlCl2 with 'PhPLi2' in THF gives [{MeAl(PPh)3Li(4).3 THF}4(mu4-Cl)]-Li+ (1). The GaIII and InIII analogues, [{MeE(PPh)3Li(4).3 THF}4(mu4-Cl)]-Li+(THF)3 (E=Ga (2), In (3)), are obtained by the in situ reactions of MeECl2 with PhPLi2 in THF. For all of the complexes, the cage anions have an unusual cubic arrangement that is similar to a zeolite, and contain large voids (ca. 17 A). The location of the Li+ counterions in 1-3 and their coordination environment appears to subtly reflect variations in packing and lattice energy. Whereas in 1 highly mobile, loosely coordinated Li+ counterions are present, 2 and 3 contain less mobile THF-solvated counterions within the cavities. X-ray crystallographic and solid-state NMR studies are reported on 1-3, together with model DFT calculations on the selectivity of halide coordination.
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PMID:Structural, solid-state NMR and theoretical studies of the inverse-coordination of lithium chloride using group 13 phosphide hosts. 1708 73

Three isostructural disklike heptanuclear FeIII compounds of the general formula [FeIII7(mu3-O)3(L)3(mu-O2CCMe3)6(eta1-O2CCMe3)3(H2O)3], where L represents a di- or triethanolamine moiety, display a three-blade propeller topology, with the central Fe atom representing the axle or axis of the propeller. This motif corresponds to the theoretical model of a frustrated Heisenberg star, which is one of the very few solvable models in the area of frustrated quantum-spin systems and can, furthermore, be converted to an octanuclear cage for the case where L is triethanolamine to give [FeIII8(mu4O)3(mu4-tea)(teaH)3(O2CCMe3)6(N3)3].1/2MeCN.1/2H2O or [FeIII8(mu4O)3(mu4-tea)(teaH)3(O2CCMe3)6(SCN)3].2MeCN when treated with excess NaN3 or NH4SCN, respectively. The core structure is formally derived from that of the heptanuclear compounds by the replacement of the three aqua ligands by an {Fe(tea)} moiety, so that the 3-fold axis of the propeller is now defined by two central FeIII atoms. Magnetic studies on two of the heptanulcear compounds established unequivocally S = 5/2 spin ground state for these complexes, consistent with overall antiferromagnetic interactions between the constituent FeIII ions.
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PMID:Odd-numbered Fe(III) complexes: synthesis, molecular structure, reactivity, and magnetic properties. 1725 17

The reaction of Cu(ClO4)2. 6H2O with t-BuP(O)(OH)2 and 3,5-(CF3)2PzH in the presence of triethylamine afforded the dodecanuclear cage ([Et3NH]2[Cu12(mu-3,5-(CF3)2Pz)6(mu3-OH)6(mu-OH)3(mu3-t-BuPO3)2(mu6-t-BuPO3)3][t-BuPO2OH][C6H5CH3]2) (2). The molecular structure of this cage revealed that it possesses a barrel-shaped architechture. The cage structure is built by the cumulative coordination action of phosphonate, hydroxide, and pyrazolyl ligands. A similar reaction involving Cu(NO3)2. 3H2O, t-BuP(O)(OH)2, 3,5-dimethylpyrazole, and triethylamine afforded another dodecanuclear cage [Cu12(mu-DMPz)8(eta1-DMPzH)2(mu4-O)2(mu3-OH)4(mu3- t-BuPO3)4].3MeOH (3). The latter is crown-shaped and is built by the coordination of pyrazole, pyrazolyl, phosphonate, hydroxide, oxide, and methanol ligands. Both of the dodecanuclear cages are efficient nucleases in the presence of magnesium monoperoxyphthalate.
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PMID:Barrel- and crown-shaped dodecanuclear copper(II) cages built from phosphonate, pyrazole, and hydroxide ligands. 1848 17

The employment of the dianion (dpkd(2-)) of the gem-diol form of di-2-pyridylketone (dpk) as a tetradentate chelate in manganese chemistry is reported, and the synthesis, crystal structure, and magnetochemical characterization of [Mn26O16(OMe)12(dpkd)12(MeOH)6](OH)6 x solv (3 x solv) are described. The reaction of Mn(ClO4)2 x 6 H2O, dpk, NaOMe, and NEt3 (2:1:4:2) in MeCN/MeOH affords complex 3, which possesses a rare metal topology and is mixed-valence (4 Mn(II), 22 Mn(III)). The complicated [Mn26(mu4-O)10(mu3-O)6(mu3-OMe)12(mu-OR)12](18+) core of 3 consists of an internal Mn(III)16 cage of adjacent Mn4 tetrahedra surrounded by an external Mn(II)4Mn(III)6 shell. The latter is held together by the alkoxide arms of twelve eta(1):eta(2):eta(1):eta(1):mu3 dpkd(2-) groups. Variable-temperature, solid-state direct current (dc), and alternating current (ac) magnetization studies were carried out on 3 in the 1.8-300 K range. Complex 3 is predominantly antiferromagnetically coupled with a resulting S = 6 ground state, a conclusion confirmed by the in-phase (chi'(M)) ac susceptibility data. The observation of out-of-phase (chi''(M)) ac susceptibility signals suggested that 3 might be a single-molecule magnet, and this was confirmed by single-crystal magnetization vs dc field sweeps that exhibited hysteresis, the diagnostic property of a magnet. Combined ac chi''(M) and magnetization decay vs time data collected below 1.1 K were used to construct an Arrhenius plot; the fit of the thermally activated region above approximately 0.1 K gave U(eff) = 30 K, where U(eff) is the effective relaxation barrier. At lower temperatures, the complex exhibits temperature-independent relaxation, characteristic of ground-state quantum tunneling of magnetization between the lowest-lying M(s) = +/-6 levels. The combined work demonstrates the ligating flexibility of dipyridyl-diolate chelates and their usefulness in the synthesis of polynuclear Mn(x) clusters with interesting magnetic properties, without requiring the co-presence of carboxylate ligands.
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PMID:High nuclearity single-molecule magnets: a mixed-valence Mn26 cluster containing the di-2-pyridylketone diolate dianion. 1884 28

Two new Mn(III) complexes with unprecedented topologies containing the tert-butylphosphonate ligand (t-BuPO3(2-)), [Mn9O6(t-BuPO3)2(O2CMe)11 (MeCOOH)(H2O)].8H2O(1), and [NBu(n)4][Mn13O6(t-BuPO3)10(OH)2(N3)6(MeCOOH)2(H2O)2].6H2O(2) have been prepared by treatment of Mn(O2CMe)2 and NBu(n)4MnO4 with tert-butylphosphonic acid in the presence of different bases. The core of 1 consists of two [Mn3O] units connected to a near linear [Mn3] unit by four mu3-O, while the core of 2 possesses a Mn centred disklike [Mn7O6] unit linked to six additional manganese atoms via six mu4-O. Compounds 1 and 2 are both homovalent manganese(III) cage clusters, of which the six-coordinated Mn centers are all Jahn-Teller distorted. Magnetic susceptibility measurements reveal that compounds 1 and 2 display overall ferromagnetic and antiferromagnetic interactions, respectively, between the adjacent Mn(III) ions. Both the in-phase signal chi'M T and out-of-phase signal chi"M, of the two complexes exhibit frequency-dependence below approximately 3 K.
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PMID:Synthesis and characterization of nona- and trideca-nuclear manganese phosphonate clusters. 1902 60

Treatment of an alkaline earth metal (Ca, Sr, Ba) with 2,4,6-trimethylphenol (HOmes) at elevated temperatures in the presence of mercury under solvent-free conditions, followed by extraction of the reaction mixture with 1,2-dimethoxyethane (dme), afforded dinuclear alkaline earth aryloxo complexes [Ae2(Omes)4(dme)4] (Ae = Ca 1, Sr 3, Ba 6). Extraction of the Ca metal and HOmes reaction mixture with thf afforded [Ca3(Omes)6(thf)] 2. In contrast, redox transmetallation ligand exchange reactions between an alkaline earth metal, diphenylmercury and HOmes in dme yielded solely 1 for Ca metal, a mixture of 3 and the methoxide bridged cage [Sr5(Omes)5(OMe)5(dme)4] x 2dme 4 for Sr metal, and solely [Ba5(Omes)5(OMe)5(dme)4] x dme 7 for Ba metal. The methoxide ligands originate from the C-O activation of the dme solvent. Treatment of liquid ammonia activated Sr or Ba metal with HOmes in thf afforded the linear species [Ae3(Omes)6(thf)6] (Ae = Sr 5, Ba 8), and 8 was also obtained from barium metal and HOmes in refluxing thf. The structures of 1 and 3, determined by X-ray crystallography, consist of two six coordinate Ae metal atoms, to each of which is bound a terminal aryloxide ligand, two bridging aryloxide ligands, and chelating and unidentate dme ligands. The structures of 4 and 7 contain five Ae metal atoms arranged on the vertices of a distorted square based pyramid. The Ae atoms are linked by four mu3-OMe ligands and a mu4-OMe ligand. Four bridging aryloxide ligands and four chelating dme ligands complete the coordination spheres of the four seven coordinate Ae atoms at the base of the pyramid, and a terminal aryloxide ligand is bound to the five coordinate apical Ae atom. The structures of 5 and 8 consist of a trinuclear linear array of Ae metal atoms, and contain solely bridging aryloxide ligands. Three thf ligands are bound to each terminal Ae atom, giving all Ae atoms a coordination number of six.
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PMID:Metal based synthetic routes to heavy alkaline earth aryloxo complexes involving ligands of moderate steric bulk. 1966 79