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Query: UNIPROT:Q86TM3 (cage)
 29,987 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Coccidial oocysts and/or vegetative germs, spores, and toxins of Cl. perfringens Type A were used in mono-infection and poly-infection experiments on SPF chicken aged seven and 56 days and kept under different conditions. Necrotic enteritis was regularly reproduced in all experimental groups with polyinfections. In chicken aged seven days necrotic enteritis was reproduced even after repeated mono-infections with 4 X 10(9) gerus and toxin of Cl. perfringens. The loss figures recorded from ground-kept infected groups were higher than those established from the cage-kept animals. The pathologica-anatomic findings recorded from the dead chicken included necrotic, ulcerative, and catarrhal to haemorrhagic intestinal inflammations, with necrotic enteritis being most strongly pronounced in the ileum and jejunum. All infected groups lost not only animals but weight as well. Their average weight on the 21 st day from the onset of infection was up to 26.4 per cent lower than that of the control groups.
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PMID:[Experimental reproduction of necrotic enteritis in the chicken. 2. Further mono- and polyinfections with CL. perfringens and coccidia with special reference to ground-kept chickens]. 19 Sep 69

Studies were undertaken to evaluate the fundamental conditions for a low-intensity voluntary wheel running model in rats and its chronic effects on health indexes. Male Fischer rats (SPF) 5 weeks of age were housed in individual sedentary conditions or in individual wheel-cage units which allowed free access to voluntary wheel running for 8 months. Voluntary running averaged 640 +/- 198 m/day, reached a peak (965m) at the 2nd month and waned over time, reaching a plateau after the 6th month (about 400-500m). Exercising rats consumed more food (+23%), but exhibited decreased body weight gains (-9%), suggesting a remarkable lowering of fat. A lowering effect on resting blood pressure (-5%) was also recognized. In addition, preventive effects on oxygen toxicity and effective bactericidal activity of neutrophils and pulmonary alveolar macrophages (PAM) were suggested. Although the amount of exercise in this study was the smallest of the other preceding ones conducted with a voluntary wheel running model, many potential health benefits were recognized. Such health promoting and protective effects by low-intensity voluntary exercise and the harmfulness of forced exercise in rats have been reported in researches on cancer, lowering fat and hypertension. Therefore it is important to set up conditions for low-intensity voluntary running. It was also demonstrated by this study that strictly controlled environmental conditions, such as room temperature and humidity, a 12-hr light-dark cycle and prevention of infection and psychological stress to rats, as well as using male rats, which are more inactive, were important factors to establish this model.
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PMID:[Conditions for low-intensity voluntary wheel running in rats and its chronic effects on health indexes]. 128 62

8,600 laboratory rats (outbred and inbred, SPF) of 3 independent breeding and experimental units, divided into groups of in 80-100 animals of equal sex and age, were housed in groups of 5 animals of the same sex and age per cage under highly standardized (SPF) conditions. The body masses were determined monthly between 8 and 56 weeks of age. The frequency distributions of body mass per group (coefficient of variation 7-12%) very frequently showed small negative kurtosis (-0.12 to -0.76) but no general tendency to skewness. Kurtosis is small and seems to have been acquired before birth and had no genetic reasons because it was also present in groups of inbred strains and in animals not selected artificially after birth. It may be caused by shortages of both tails of the frequency distribution of the body mass.
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PMID:Frequency distribution of body mass in groups of highly standardized laboratory rats are characterized by negative kurtosis. 214 24

A 21 week experiment was conducted with male SPF Ico/Shoe: WIST rats to study the influence on diagnostic parameters of toxicological studies of (i) acidification of drinking water by hydrochloric acid (untreated tap water vs. pH 3 vs. pH 2), (ii) individual vs. group caging (5 animals/cage), and (iii) ad libitum vs. 10 ml restrictive water supply. Acidification to pH 2 resulted in a slightly but significantly reduced excretion of phenol red, lowered proteinuria and a decreased urine volume, whereas all other parameters remained unchanged. Individual caging was less stressful than expected from published data. Red blood cell counts were increased, water consumption and urine volume were somewhat lowered, but stress-sensitive parameters like adrenal weight, leucocyte and lymphocyte counts were not altered. A 10 ml restrictive water supply decreased urine volume, food consumption, body weight development and organ weights. Furthermore transient increases in red blood cell counts and hemoglobin contents, leucopenia and--most important--an impaired renal function were observed. In conclusion acidification of drinking water with hydrochloric acid should not be lower than pH 3, male Ico/Shoe: WIST rats can be regarded as minimum susceptible to individual caging, and reduced water intake might give false positive nephrotoxic effects.
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PMID:Effects of drinking water acidification, restriction of water supply and individual caging on parameters of toxicological studies in rats. 252 65

SPF cats were experimentally infected orally with bovine rotavirus. All of them excreted virus over a period of at least two weeks after inoculation. Seroconversion was observed after one week for all the animals, but it did not stop viral excretion or prevent further excretion of the same or another rotavirus strain given later. Cats or dogs kept in the same cage as inoculated animals became infected and excreted virus, but seroconversion was not observed in these contact animals. None of the animals developed diarrhoea during the experiment. Cats are thus able to multiply bovine rotavirus, and transmission of this virus occurs between cats or between dogs and cats. Therefore, cats, like dogs, may play a role in the epizootiology of rotavirus infection in calves.
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PMID:Propagation of bovine rotavirus by cats and dogs. 630 66

In a longevity study with SPF rats of the Han:Wistar outbred stock, 320 virgin males and 320 virgin females of marked littermates were maintained in a barrier-type animal house under highly standardized conditions from weaning until their natural end of life. Diseased and dead animals were sectioned and examined using histological, bacteriological and virological methods. The mortality of the rats is low up to the 18th month of life. Thereafter the mortality graph inclines steadily. The course of the graph is determined by very few diseases only, such as pituitary adenomas in both sexes, adenocarcinomas of the uterine glands in the females, and in the third and fourth year nephropathies in the males. Because of the high number of adenocarcinomas of the uterine glands the median life expectancy is between 30 and 33 months for the females, somewhat lower than between the 33rd and the 36th months for the males. The disease spectrum consists generally of tumor lesions, but out of the large tumor spectrum only single alterations exceed the 5% border. As shown by analysis of variance and estimation of the heritability coefficients (h2), mortality and the most important tumorous lesions underlie high genetic effects. The cage environments are found to have no influence upon mortality and diseases. Under the given standardized environmental conditions, the present results can be looked upon--because of the strong genetic effects on mortality and diseases - to be representative for correspondingly selected populations of future generations of the Han:Wistar stock.
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PMID:Genetic and environmental influences on lifespan and diseases in Han:Wistar rats. 720 22

This study determined the extent of arsenic (As) absorption from soil from Anaconda, Montana. Prepubescent male and female SPF New Zealand White rabbits (5/sex/group) were given a single oral (capsule) administration of soil (3900 ppm As) at three different dose levels (0.2, 0.5, and 1.0 g of soil/kg, corresponding to 0.78, 1.95, and 3.9 mg As/kg, respectively). Standard groups included untreated controls, an intravenous sodium arsenate group (1.95 mg As/kg), and a gavage sodium arsenate group (1.95 mg As/kg). Urine, cage rinse, and feces were collected at 24-hr intervals for 5 days and were analyzed for total As concentration. Clinical signs, body weights, and food consumption for treated animals were similar to controls. Maximum As concentrations were obtained over the initial 24-hr collection interval. A dose-dependent delay in urinary As excretion, the major elimination pathway, was observed in the oral soil group compared to that in the gavage group. For the animals in the soil groups, approximately 80% of the administered As dose was eliminated in the feces compared to approximately 10 and 50% for the intravenous and oral gavage groups, respectively. The relative oral bioavailabilities (+/- SD) of As in the gavage and test soil groups based on comparison with excreta data from the intravenous group were approximately 50 +/- 5.7 and 24 +/- 3.2%, respectively (after normalization of intravenous group's As recovery data to 100%). These results indicated that As in the soil was probably in a less soluble and therefore a less absorbable form than sodium arsenate.
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PMID:Bioavailability of arsenic in soil impacted by smelter activities following oral administration in rabbits. 836 90

Gnotobiotic Wistar rats were produced using gnotobiotic techniques, which were established in the production of a SPF mouse colony, in order to establish a barrier-sustained colony. One strain of Escherichia coli, 28 strains of Bacteriodaceae (B-strains), three strains of Lactobacillus (L-strains) and a chloroform-treated fecal suspension (CHF, Clostridium mixture) were prepared from conventional Wistar rats as the microflora source. Two groups of limited-flora rats, E. coli plus B-strains and E. coli plus CHF, were produced. After confirmation that Clostridium difficile was not detected in the CHF-inoculated rats, two groups of limited-flora rats were transferred to an isolator and housed together in a cage. These rats were then orally inoculated with L-strains. The gnotobiotic rats showed colonization resistance to Pseudomonas aeruginosa, and the number of E. coli in the feces was 10(5) to 10(6)/g. The gnotobiotic rats were transferred to a barrier room as a source of intestinal flora for SPF colonies. In the SPF rats, basic cecal flora was mainly composed of Bacteroidaceae, clostridia, fusiform-shaped bacteria and lactobacilli, and did not change over a long period. Their flora became similar to that of conventional rats.
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PMID:Establishment of specific pathogen-free (SPF) rat colonies using gnotobiotic techniques. 1151 91

In 2000, the authors found endemic infections of mouse hepatitis virus, minute virus of mice, Syphacia obvelata, and Myobia musculi among mice in a large barrier facility at the University of Mainz. To eliminate the infections, they subdivided the facility into two distinct hygiene units. However, architectural constraints made it impossible to completely separate the HVAC systems of both hygiene units and to establish adequate personnel locks. To compensate for these suboptimal barrier conditions of the two newly established units, the authors replaced the open-top caging and open-servicing system with filter-top cages that were manipulated in cage-changing stations. The authors then depopulated the two units in series, independently eliminating the contaminated mice and restocking the units with SPF animals. In spite of the high infection pressure and the suboptimal barrier conditions, the authors had only a single case of recontamination.
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PMID:Decontamination of a barrier facility using microisolator cages and provisional partitioning. 1758 55

Wild rodents, and especially rats, are significantly more difficult to handle, maintain and breed than laboratory rats and mice. They can be characterized as more skittish, neophobic and aggressive. While establishing a breeding colony of wild Norwegian rats (Rattus norvegicus) I developed some helpful devices and I will describe them here. In this paper I also describe the techniques for transporting animals between their home cages, separating them inside cages, and catching individuals that escape. These devices do not require any home cage modification. They may be modified for size. With size modification these devices may be used for handling animals in any type of laboratory cages. They may be used with all species of small mammals, for example, mice, gerbils, hamster, and opossums. They prove especially helpful when physical contact with humans is a problem (e.g. SPF conditions of breeding, and behavioral procedures that do not allow handling).
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PMID:Devices for handling small mammals in laboratory conditions. 1866 64


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