Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q86TM3 (cage)
 29,987 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Various minor tranquilizers (benzodiazepines, barbiturates and meprobamate) induced an increase in the food intake of rats or mice. Drugs were injected i.p. 30 min before testing and the amount of food consumed during 30 min was recorded. The enhanced food consumption occurred when the animals were in a novel situation, in a situation which they had previously experienced, or in their home cage, in which they were used to eating in the daytime within 30 min. Studies with two benzodiazepines showed this effect to be maximal between 10 to 30 min after injection and to disappear 4 hrs after injection. Moreover, minor tranquilizers reduce the latency before eating of rats and mice tested in a new situation. These results and the observation of anti-anxiety drugs-induced hyperphagia in satiated animals suggest that: 1. The enhanced food consumption of a non familiar food in a novel situation induced by the minor tranquilizers could hardly be related only to their anti-anxiety action. 2. The existence of some inhibitory controls (endogenous satiety in daytime or satiety after recent absorption) is not essential for the action of the minor tranquilizers. 3. An increased motivation and a disruption in the food related behavior could possibly be an explanation for all the observed effects.
Psychopharmacologia 1975 Dec 31
PMID:[Effects of antianxiety drugs on the food intake in trained and untrained rats and mice (author's transl)]. 0 42

The importance of the role of toxoplasma oocysts in the mode of spread of the infection for men and animal has differently been estimated. In own earlier experiments, we found out that the transmission of the infection by means of oocysts from cat to cat is not the rule. In a similar experimental setup, we tested now whether rabbits can be infected by getting into contact with faeces of cats containing sporulated toxoplasma oocysts (see table 1). 8 toxoplasma-free rabbits and two toxoplasma-free cats as control were placed on infectious faeces of 10 cats (group 1-8). As further controls served four non-infected rabbits being kept in the same cage (group 11-12). Four of eight rabbits which had been placed on the infectious faeces and one control animal having had no intended contact with those faeces got infected. Our experiments show that the question whether domestic cats have any significance as source of infection with toxoplasms cannot generally be answered. It has to be differentiated each time which mammal gets into contact with oocysts.
Zentralbl Bakteriol Orig A 1979 Dec
PMID:[Transmission of toxoplasma oocysts from domestic cats to rabbits (author's transl)]. 4 48

The sleep pattern of sixteen baboons (Papio papio) was studied under two very different conditions: (1) in a laboratory at Marseilles, the monkey being immobilized in a restraining chair in a soundproof cubicle; (2) in an African reserve, the monkey being housed in a large cage placed in its natural environment. Some very marked differences emerged. Sleep in the laboratory was longer (by 24 min) and richer in stage 3 and paradoxical sleep. In Africa, however, the sleep showed much more stage 1, was more fragmented and stages 2 and 3 and paradoxical sleep episodes were of shorter duration. Records made in Africa indicate that sleep is independent of slight environmental changes (day length, brightness of the moon, variations in temperature, calls of predators). But the comparison of the two series of results reveals the reorganization which occurs when the monkey is exposed to such different conditions. This adaptation to the environment affects, unequally, the various slow sleep stages and paradoxical sleep. In fact, the major modifications occur in stages 1 and 3 of slow sleep and in paradoxical sleep, while stage 2 appears to constitute the stable, unmodifiable nucleus of sleep.
Electroencephalogr Clin Neurophysiol 1975 Dec
PMID:The sleep of the baboon, Papio papio, under natural conditions and in the laboratory. 5 45

Herpesvirus saimiri was naturally transmitted from squirrel monkeys excreting the virus to one of two owl monkeys housed in the same cage. The owl monkey became infected approximately three months after contact was initiated. H. saimiri was consistently isolated from the peripheral lymphocytes until this animal died eight months later. During this period the owl monkey developed specific antibody to H. saimiri to a maximal neutralization index of 5.5 logs. The other monkey remained uninfected for an ovservation period of one year. The documentation of this horizontal transmission of H. saimiri infection from squirrel monkeys to an owl monkey suggests that owl monkeys developing spontaneous malignant lymphomas associated with H. saimiri infection may also have acquired the infection in this manner.
J Infect Dis 1975 Dec
PMID:Experimental horizontal transmission of Herpesvirus saimiri from squirrel monkeys to an owl monkey. 17 63

The accumulation of bone-seeking radiopharmaceuticals in extraosseous lesions has been reported in patients with myocardial infarctions, cerebral infarctions, and some soft-tissue tumors. While the precise mechanisms involved remain uncertain, the spectrum of abnormalities exhibiting such accumulation increases. In our laboratory, 99mTc-diphosphonate concentrated in four hepatic tumors (one cholangiocarcinoma and three metastases from colon carcinoma). This property of phosphate-related radiopharmaceuticals has not been reported previously. Awareness of the possibility of focal diphosphonate accumulation in the liver should help avoid confusion with right lower rib-cage metastasis or pleural effusion.
J Nucl Med 1976 Dec
PMID:Accumulation of 99mTc-diphosphonate in four patients with hepatic neoplasm: case reports. 18 68

1. Renin-associated, chronic psychosocial hypertension of 150-160 mmHg develops in groups of mice interacting socially in complex population cages. 2. The blood pressures of 16 males in a cage were measured and an intraperitoneal injection of the angiotensin coverting enzyme inhibitor captopril (SQ 14,225) was given. Three hours later blood pressures were measured again. 3. During the first 3 weeks of psychosocial hypertension SQ 14,225 was without effect. But at 1 month and subsequently up to 7 months, SQ 14,225 reduced blood pressure to the normal range of 120-130 mmHg. 4. Plasma renin activities were not related to the extent of blood pressure reduction by SQ 14,225. Hence other factors in addition to the renin-angiotensin mechanism play a part in maintaining chronic psychosocial hypertension.
Clin Sci (Lond) 1979 Dec
PMID:Effects of an angiotensin converting enzyme inhibitor on psychosocial hypertension in mice. 23 19

A chronic pulmonary disease was encountered in nude mice of a barrier sustained colony, and Pneumocystis carinii was identified as the causative agent histopathologically as well as on impression smear preparations in the affected lungs. Fatal infection was seen only in old nude mice aged more than 6 months, while focal pulmonary lesions were developed without clinical signs in young adult nudes 2 to 3 months of age. The lesions produced in aged nude mice were characterized by propagation of mononuclear cells with the presence of foamy masses of P. carinii. Heterozygous littermates were much less susceptible to the infection but pneumocystic lesions could be produced readily by multiple treatment with immunosuppressants. The infection could be transmitted without immunosuppressant to non-infected nudes but not to heterozygous littermates after intranasal inoculation of affected tissue emulsion or by cage mating with severely affected nudes.
Jpn J Exp Med 1977 Dec
PMID:Chronic fatal pneumocystosis in nude mice. 30 93

The effects of sustained constriction of the rib cage (RCC), constriction of the abdomen (AC) and of breathing against a positive pressure of 10 cms of water (PPB) were studied in four normal subjects with moderate constant hypercapnia. Intercostal electrical activity (Eic) was measured by implanted wire electrodes and diaphragmatic electrical activity (Edia) by oesophageal electrodes. There was no fixed relation between Edia and VT. VT was unaltered during AC and RCC: Edia was unaltered during AC but increased during RCC. The response to PPB without constriction varied: three subjects increased end-expiratory VL with increase in Edia and inspiratory Eic. One subject initially, and one subject after training, maintained end-expiratory VL constant with no change in Edia and an increase in expiratory Eic. When PPB was applied during AC and RCC there was an increase in Edia proportional to end-expiratory lung volume. The overall response to distortion was determined by voluntary choice, but muscle electrical activity reflected chest wall configuration: when the diaphragm was shorter and at a mechanical disadvantage its electrical activity increased. This was compatible with a reflex with afferent information from diaphragm tendon organ and muscle spindle receptors.
Respir Physiol 1978 Dec
PMID:Muscle activity during chest wall restriction and positive pressure breathing in man. 36 29

Congenitally athymic nude mice (nu/nu) were infected intravenously with Mycobacterium bovis BCG Japanese strain under specified pathogen-free (SPF) or germ-free (GF) conditions. SPF euthymic litter mates (nu/+) serving as controls were found to tolerate the infection well, while SPF nu/nu mice following infection of 3 X 10(7) organisms died by week-36. Animals having received a very small dose (3 X 10(0) of organisms and their non-infected cage mates showed no evidence of infection at week 37 post-infection. Time-course observations carried out on SPF and GF nu/nu mice following infection with 10(5) or 10(6) organisms revealed that the number of organisms in the liver and spleen reached 10(6) to 10(7) viable units per organ at week 12 and this level was maintained for 50 weeks post-infection. Bacillary counts in the kidney and lung increased progressively and reached a level of 10(7) to 10(8) at the terminal stage of infection. In the liver, spleen and lymph nodes of nu/nu mice, granulomas were noted 12 weeks postinfection. The granulomas were composed of macrophages and accompanied by slight infiltration of lymphocytes, plasma cells and a small number of polymorphonuclear leucocytes. In later infection stages, small aggregations of pigmented macrophages packed with acid-fast bacilli were present in the liver, spleen and lymph nodes. Lesions with large foci of bacilli-laden macrophages developed progressively in the kidney, lung and subcutaneous and periosteal connective tissues. Periosteal granulomatous lesions, sometimes accompanied by exudation, intruded occasionally into the bone marrow, resulting in extensive granulomatous osteomyelities.
Jpn J Exp Med 1978 Dec
PMID:Progressive and fatal infection with attenuated Mycobacterium bovis (BCG) in nude mice. 37 3

Movements of the chest wall during the interval between an acoustic stimulus and the subject's vocal response were examined and timed in eight normal males. The reaction-time interval was divisible into two phases, a latency period with duration independent on chest wall status at the time of stimulus and an adjustment period during which the rib cage and abdomen usually moved oppositionally to achieve a prephonatory postural set. The time required for this adjustment varied significantly with lung volume, but was independent of the ventilatory phaze previously in progress.
J Speech Hear Res 1979 Dec
PMID:Chest wall movements prior to phonation. 51 93


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