Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q86TM3 (cage)
 29,987 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Design and construction of stable adsorbents for efficient separation and purification of natural gas and C2H2 is fundamentally important in the chemical industry, and hierarchical cage-based MOFs are attractive in this regard due to their intrinsic structural advantages. In this work, a cage-based MOF (termed ZJNU-15) assembled from a tetranuclear Cu4O-based SBU and an amine-functionalized N,O-mixed donor ligand was solvothermally constructed. Single-crystal X-ray diffraction studies showed that the resulting MOF incorporates two different types of polyhedral cages in the entire network and bears incompatible open copper sites and uncoordinated amine groups immobilized in the pore surface. In view of its intriguing structural features, its gas adsorption properties with respect to C2 hydrocarbons, CO2, and CH4 were systematically investigated, revealing that it could achieve efficient removal of C2 hydrocarbons and CO2 from CH4 as well as separation of a binary C2H2-CO2 mixed gas, which is associated with natural gas and C2H2 separation and purification. At 298 K and 1 atm, for equimolar binary components, the IAST-predicted adsorption selectivities for C2 hydrocarbons over CH4 are above 17.7, while the CO2/CH4 and C2H2/CO2 adsorption selectivities are 5.0 and 4.4, respectively. Notably, stability studies showed that the framework maintained its structural integrity after being immersed in HCl/NaOH aqueous solutions within a pH range of 4-11 at ambient temperature for 24 h, indicating its good hydrolytic stability under harsh chemical conditions, which might lay a solid foundation for its practical applications.
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PMID:A hydrostable cage-based MOF with open metal sites and Lewis basic sites immobilized in the pore surface for efficient separation and purification of natural gas and C2H2. 3211 37

An acid-base neutralization technique has generated interest for the ability to achieve an enhanced dissolution of pH-dependent weakly basic or acidic poorly water-soluble drugs. However, the underlying nanonization mechanism, following acid-base neutralization, requires further elucidation. We hypothesized that the nanosuspensions (NSPs) via nanonization of drug particles could be attributed to the "salt-induced effect" and surfactant-driven micellization after acid-base neutralization. Rebamipide (RBM) and valsartan (VAL) were chosen as model drugs owing to poor water solubility and pH-dependent aqueous solubility. The drug NSP was rapidly obtained via salt formation (NaCl) after neutralization of the drug in basic NaOH solution and poloxamer 407 (POX 407) in acidic HCl solution. The NSP surrounded by NaCl salt was further stabilized by POX 407. The resulting NaCl salt modulated the critical micelle aggregation of POX 407, stabilizing the drug-loaded NSP in a cage of salt and micellar surfactant. In non-assisted homogenization, size analysis indicated the relationship between salt concentration and size reduction. Fourier transform infrared (FTIR) spectra revealed that the existence of hydrogen bonding between the drug and surfactant after neutralization, attributed to NSP size reduction. Changes in drug crystallinity to the nano-amorphous state were confirmed by powder X-ray diffraction (PXRD). Overall, the salt-induced drug NSP synergistically enhanced the dissolution rate, narrowing a gap between drug dissolution profiles in different pH environments.
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PMID:Mechanistic understanding of salt-induced drug encapsulation in nanosuspension via acid-base neutralization as a nanonization platform technology to enhance dissolution rate of pH-dependent poorly water-soluble drugs. 3263 69


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