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Query: UNIPROT:Q86TM3 (cage)
 29,987 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Several independent synthetic routes are described leading to the formation of a novel unsaturated tetracyclic phosphorus carbon cage compound tBu4C4P6 (1), which undergoes a light-induced valence isomerization to produce the first hexaphosphapentaprismane cage tBu4C4P6 (2). A second unsaturated isomer tBu4C4P6 (9) of 1 and the bis-[W(CO)5] complex 13 of 1 are stable towards similar isomerization reactions. Another starting material for the synthesis of the hexaphosphapentaprismane cage tBu4C4P6 (2) is the trimeric mercury complex [(tBu4C4P6)Hg]3 (11), which undergoes elimination of mercury to afford the title compound 2. Single-crystal X-ray structural determinations have been carried out on compounds 1, 2, 9, 11, and 13.
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PMID:Hexaphosphapentaprismane: a new gateway to organophosphorus cage compound chemistry. 1218 Mar 42

Reaction of the lithium triamidostannate [MeSi[SiMe(2)N(p-Tol)](3)SnLi(OEt(2))] (1) with 0.5 molar equivalents of MCl(2) (M=Zn, Cd, Hg) in toluene afforded the corresponding heterodimetallic complexes [MeSi[SiMe(2)N(p-Tol)](3)Sn](2)M [M=Hg (2), Cd (3), and Zn (4)]. The molecular structures of the mercury and cadmium complexes were determined by X-ray diffraction and found to adopt a linear Sn-M-Sn metal-metal bonded array (d(Sn-Hg) 2.6495(2), d(Sn-Cd) 2.6758(1) A), these being the first Hg-Sn and Cd-Sn bonds to be characterized by X-ray diffraction. That the Hg-Sn bonds are shorter than the Cd-Sn bonds in the isomorphous complexes is attributed to relativistic effects in the mercury system. In contrast, the structure of the Zn analogue is unsymmetrical with one stannate unit being Sn-Zn bonded (d(Sn(1)-Zn) 2.5782(4) A), while the Zn(II) atom bridges two amido functions of the second stannate cage, thus representing a second isomeric form of these complexes. The different degree of metal-metal bond polarity is reflected in the (119)Sn NMR chemical shifts of the three complexes. Variable-temperature NMR studies and a series of (1)H ROESY experiments of the cadmium complex 3 in solution revealed a dynamic exchange between the two isomers.
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PMID:Metal-metal bonds between group 12 metals and tin: structural characterization of the complete series of Sn-M-Sn (M=Zn, Cd, Hg) heterodimetallic complexes. 1220 58

In the present study, electrospray ionization mass spectrometry is used to evaluate the metal-binding selectivities of an array of novel caged macrocycles for mercury(II), lead(II), cadmium(II), and zinc(II) ions. In homogeneous methanol/chloroform solutions as well as extractions of metals from aqueous solution by macrocycles in chloroform, it is found that the type of heteroatom (S, O, N), cavity size, and presence of other substituents influence the metal selectivities. Several of the macrocycles in this study bind mercury ion very selectively and efficiently in the presence of many other metal ions and have an avidity toward mercury that was tunable by the size and combination of heteroatoms in the macrocycle ring and the number of cage groups attached. The extraction mechanism was further investigated by determining the variation in extraction selectivity as a function of the counterions of the mercury salts.
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PMID:Metal complexation of thiacrown ether macrocycles by electrospray ionization mass spectrometry. 1223 51

Easily observed on the single molecule level, highly fluorescent and photostable silver nanoclusters have been photochemically prepared within poly(amidoamine) dendrimer hosts in aqueous solutions. The dendrimer cage stabilizes and solubilizes the nanoclusters to yield highly stable, photoactivated single nanodots ranging in size from 2 to 8 silver atoms. These multicolored, highly fluorescent species are extremely photostable and readily observed on the single molecule scale with weak mercury lamp excitation. Such easily created, bright, photoactivated water-soluble fluorophores are likely to greatly expand the impact of single molecule labeling studies in a wide variety of systems.
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PMID:Individual water-soluble dendrimer-encapsulated silver nanodot fluorescence. 1244 Aug 82

The deep-red, air-stable complexes [Pt(2)Hg(2)(P(2)phen)(3)](PF(6))(2), 1, or [Pd(2)Hg(2)(P(2)phen)(3)](PF(6))(2), 2, (P(2)phen is 2,9-bis(diphenylphosphino)-1,10-phenanthroline) are most conveniently prepared by the stoichiometric reaction of either Pt(dba)(2) or Pd(2)(dba)(3).CHCl(3) (dba is dibenzylideneacetone) with P(2)phen and a single drop of elemental mercury in refluxing dichloromethane under an atmosphere of nitrogen. The (31)P[(1)H] NMR spectrum (CD(3)CN) of 1 shows a single sharp resonance at 43.1 ppm for the phosphorus atoms of the P(2)phen ligand with both (195)Pt ((1)J(P-Pt) = 4350 Hz) and (199)Hg ((2)J(P-Hg) = 620 Hz) satellites indicating the Hg(2)(2+) unit is dynamic. Compound 2 has a similar resonance at 44.9 ppm with (199)Hg satellites ((2)J(P-Hg) = 638 Hz). The (199)Hg NMR (CD(2)Cl(2), vs Hg(OAc)(2)) spectrum of 2 shows a heptet pattern at 833 ppm while for 1 a heptet superimposed on a doublet of heptets is observed at 770.8 ppm. The (195)Pt NMR spectrum of 1 displays a quartet at -3071 ppm with (199)Hg satellites and a (1)J(Pt-Hg) value of 1602 Hz. Characterization of 1 and of 2(BF(4)(2) by single-crystal X-ray diffraction studies confirms the metallocryptand structure consisting of three phosphine-imine ligands forming a D(3) symmetric cage with a Hg(2)(2+) ion in its center coordinated to two phenanthroline rings with the Hg-Hg bond (1, 2.7362(6); 2(BF(4)(2), 2.6881(4) A) oriented perpendicular to the vector between the trigonally coordinated Pt(0) or Pd(0) atoms on each end. The Pt-Hg separations in 1 average 2.8143(6) A while in 2(BF(4)(2) the average Pd-Hg separation is 2.7698(5) A. Excitation into the low energy excitation bands of 1 (475 nm) and 2 (430 nm) produces weak emissions centered at 593 nm with shoulders at 530 and 654 nm in 1 and centered at 524 nm with a shoulder at 545 nm in 2.
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PMID:Pd(0) and Pt(0) metallocryptands encapsulating a spinning mercurous dimer. 1247 50

We present inelastic neutron scattering measurements on liquid mercury at room temperature for wave numbers q in the range 0.3 <q<7.0 A(-1). We find that the energy half width of the incoherent part of the dynamic structure factor S(q,E) is determined by a self-diffusion process. The half width of the coherent part of S(q,E) shows the characteristic behavior expected for a cage diffusion process. We also show that the response function at small wave numbers exhibits a quasielastic mode with a time scale characteristic of cage diffusion, however, its intensity is larger by an order of magnitude than what would be expected for cage diffusion. We speculate on a scenario in which the intensity of the cage diffusion mode at small wave numbers is amplified through a valence fluctuation mechanism.
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PMID:Cage diffusion in liquid mercury. 1475 93

A novel separation method for random screening of target cells from a large heterogeneous population by using a local photo-polymerization is developed. A photo-crosslinkable resin solution is mixed with the sample liquid and we controlled the state from sol to gel by irradiating the near ultraviolet (UV) light with the mercury lamp and He-Cd laser near the target cell. We applied three types of immobilization methods such as direct immobilization method, caging method, and direct immobilization with position control method. The selected cell is immobilized in the cured resin directly or inside the cage of the cured resin. In the position control method, laser tweezers are employed to manipulate the target cell indirectly by using the droplet of the resin as a microtool. The cell is positioned properly by the laser manipulation system and is immobilized in the polymerized resin. After the selected cells are immobilized we can easily remove the other objects by the cleaning flow in the microchannel since the polymerized resin strongly binds with the cover glass and resists more than 466 mm s(-1) flow speed in the microchannel (microchannel size: width is 500 micron and depth is 100 micron). We tested the mercury lamp as well as the He-Cd laser for UV-light irradiation at the local area and confirmed improvement of resolution of the cured area by using the He-Cd laser (from 7 micron to 5 micron). Based on this method, we succeeded in single cell immobilization and basic experiments such as culture and fluorescent dyeing of immobilized yeast cells.
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PMID:Immobilization of individual cells by local photo-polymerization on a chip. 1572 58

We describe the basis of a new design for a user-friendly and easily reproduced mercury-displacement plethysmograph. This system was validated using the rat adjuvant-induced arthritis model in female Lewis rats. Furthermore, 2 different caging systems were evaluated to ensure that caging did not have an effect on disease progression and severity. These groups were evaluated further under frequent- and infrequent-handling conditions. Housing had less effect on the amount of swelling seen during the disease than did the amount of handling. Frequent handling significantly reduced the degree of paw swelling. Frequently handled, arthritic rats housed 5 rats per cage in the Box B system also lost a biologically significant amount of weight by the end of the study. Therefore, we do not recommend housing more than 4 rats per cage under these conditions.
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PMID:Evaluation of a potential stress effect in rat adjuvant arthritis by using a new and efficient plethysmograph. 1664 70

The Cape Fear shiner (Notropis mekistocholas) is a recently described cyprinid species endemic to the Cape Fear River Basin of North Carolina, USA. Only five populations of the fish remain; thus, it is listed as endangered by the U.S. Government. Determining habitat requirements of the Cape Fear shiner, including water quality and physical habitat, is critical to the survival and future restoration of the species. To assess water quality in the best remaining and in the historical habitats, we conducted a 28-d in situ bioassay with captively propagated Cape Fear shiners. Fish were deployed at 10 sites in three rivers, with three cages per site and 20 fish per cage. Water and sediment samples were collected and analyzed for selected metals and organic contaminants. Passive sampling devices also were deployed at each site and analyzed for organic contaminants at test termination. Fish survival, growth (as measured by an increase in total length), and contaminant accumulation were measured on completion of the bioassay. Survival of caged fish averaged 76% (range, 53-100%) and varied significantly among sites and rivers. Caged fish accumulated quantities of cadmium, mercury, polychlorinated biphenyls, and other persistent contaminants over the test duration and grew significantly at only four sites. No apparent relations were observed between exposure to or accumulation of a specific contaminant and reduced growth or survival of fish among all the sites. However, a generalized hazard assessment showed that certain sites exhibited trends in cumulative contaminant presence with reduced fish survival and growth, thereby enabling the identification of the existing riverine habitat most suitable for reintroduction or population augmentation of this endangered fish.
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PMID:Influence of water quality and associated contaminants on survival and growth of the endangered Cape Fear shiner (Notropis mekistocholas). 1698 82

'Caged' compounds are biological molecules that are rendered inactive by a protecting (cage) group. Photocleaving of chemical bonds associated with the cage species with intense UV light results in the release of the active molecules. This technique, called flash photolysis, allows for real-time study of interacting biological molecules and typically involves the use of high intensity lasers or flash lamps to deliver the UV pulse to the biological specimen [Callaway EM, Katz LC. Photostimulation using caged glutamate reveals functional circuitry in living brain slices. Proc Natl Acad Sci USA 1993;90(16):7661-5; Parpura V, Haydon PG. "Uncaging" using optical fibers to deliver UV light directly to the sample. Croat Med J 1999;40(3):340-5; Denk W. Pulsing mercury arc lamps for uncaging and fast imaging. J Neurosci Methods 1997;72(1):39-42]. Here, we introduce compact, custom-designed semiconductor UV light-emitting diodes (LEDs) as a viable and efficient source for performing flash photolysis studies, focusing specifically on the application of these devices for uncaging neurotransmitters locally onto neurons cultured on artificial substrates. The illumination design feature incorporated in these devices allows for direct placement of the UV source in immediate proximity with the neuron of interest and provides a means for optical triggering of activity in the neuronal culture.
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PMID:Semiconductor ultra-violet light-emitting diodes for flash photolysis. 1700 8


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