Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:Q86TM3 (
cage
)
29,987
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The tumor stroma has the capacity to drive cancer progression, although the mechanisms governing these effects are incompletely understood. Recently, we reported that deletion of tissue inhibitor of metalloproteinases (Timps) in fibroblasts unleashes the function of
cancer-associated
fibroblasts and identifies a novel mode of stromal-tumor communication that activates key oncogenic pathways invoving Notch and
ras homolog gene family, member A
(
RhoA
) via stromal exosomes.
...
PMID:Tumor suppression by stromal TIMPs. 2731 4
