Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:Q86TM3 (
cage
)
29,987
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In this study, we designed and synthesized a highly stable manganese (Mn
2+
)-based hepatobiliary complex by tethering an ethoxybenzyl (EOB) moiety with an ethylenediaminetetraacetic acid (EDTA) coordination
cage
as an alternative to the well-established hepatobiliary gadolinium (Gd
3+
) chelates and evaluated its usage as a T
1
hepatobiliary magnetic resonance imaging (MRI) contrast agent (CA). This new complex exhibits higher r
1
relaxivity (2.3 mM
-1
s
-1
) than clinically approved Mn
2+
-based hepatobiliary complex Mn-DPDP (1.6 mM
-1
s
-1
) at 1.5 T. Mn-EDTA-EOB shows much higher kinetic inertness than that of clinically approved Gd
3+
-based hepatobiliary MRI CAs, such as Gd-DTPA-EOB and
Gd-BOPTA
. In addition, in vivo biodistribution and MRI enhancement patterns of this new Mn
2+
chelate are comparable to those of Gd
3+
-based hepatobiliary MRI CAs. The diagnostic efficacy of the new complex was demonstrated by its enhanced tumor detection sensitivity in a liver cancer model using in vivo MRI.
...
PMID:Synthesis and Evaluation of Manganese(II)-Based Ethylenediaminetetraacetic Acid-Ethoxybenzyl Conjugate as a Highly Stable Hepatobiliary Magnetic Resonance Imaging Contrast Agent. 3038 68
