Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q86TM3 (cage)
 29,987 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Various behavioral sequelae have been noted in patients receiving prolonged, high-dose glucocorticoid therapy. The present study assayed several behavioral dimensions of rats receiving daily intramuscular injections of the synthetic glucocorticoid, prednisolone. Specifically, assessments of water intake, nociception, locomotion, and the grasping responses were conducted; measures of gonadal, adrenal, and total body weights were also taken. Twelve daily injections were given to four groups (N = 6/group) of immature male rats with each group receiving a different dose of drugs (0.0, 8.0, 16.0, 32.0 mg/kg). Prednisolone generally suppressed home-cage water intake, and latencies to hind paw-lick in the hot-plate assay. Measures of wheel running and the grasping response were generally enhanced. Absolute gonadal and adrenal weights as well as total body weights were decreased. Relative organ weights suggested that daily prednisolone treatments had produced suppression of the pituitary-adrenal axis. It was concluded that prednisolone is active in these assays and that such measures may be useful in studies of drug interaction with this agent.
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PMID:Prednisolone effects upon body and organ weights, water intake, and several behaviors. 716 54

A five-year-old boy with deforming and destructive invasion of pulmonary aspergillosis to the thoracic cage was diagnosed as having chronic granulomatous disease. Conventional antifungal therapy failed in this patient. Prednisolone therapy was added and rapidly improved the general condition of patient but deterioration had already been very rapid. The failure of systemic therapy prompted us to give amphotericin B locally to the granulomatous lesions through the bronchocutaneous fistula. This application yielded a good clinical response with closure of fistula. Despite this improvement the patient died from septicemia. We believe that systemic prednisolone treatment is useless in such cases, but local application of amphotericin B into the granulomatous lesions together with systemic therapy during the earlier stages of infection can contribute to a change in prognosis.
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PMID:Invasive pulmonary aspergillosis in chronic granulomatous disease: response to systemic prednisolone treatment and locally applied amphotericin B. 782 43