Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q86TM3 (cage)
 29,987 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lung volumes are decreased by tense ascites and increase after large volume paracentesis (LVP). The overall effect of ascites and LVP on the respiratory function is poorly understood. We studied eight cirrhotic patients with tense ascites before and after LVP. Inspiratory muscle force (maximal transdiaphragmatic pressure (Pdi,max), and the lowest pleural pressure (Pp1,min)) was assessed while the patients were seated. Rib cage and abdominal volume displacements, as well as pleural and gastric pressures were measured during quiet breathing while the patients were supine. Pdi,max and Ppl,min were normal and did not change after LVP (from 84.2+/-19.7 to 85.2+/-17.0 cmH2O and from 68.3+/-19.7 to 74+/-15.9 cmH2O, respectively). The abdominal contribution to the generation of tidal volume was greater than that of the rib cage (79 vs 21%), a pattern which did not change after LVP (73 and 27%). Before LVP, tidal swings both of pleural pressure (Ppl,sw) and transdiaphragmatic pressure (Pdi,sw) were large (15.3+/-4.3 and 18.5+/-3.9 cmH2O, respectively) and the load on inspiratory muscles was increased as a consequence of elevated dynamic elastance of the lung (El,dyn) (11.4+/-2.6 cmH2O x L(-1)) and ("intrinsic") positive end-expiratory pressure (PEEPi) (4.3+/-3.5 cmH2O). LVP reduced the load on the inspiratory muscles, as shown by the significant decrease in Ppl,sw (10.6+/-2.0 cmH2O), Pdi,sw (12.8+/-3.0 cmH2O), El,dyn (10.0+/-2.0 cmH2O x L(-1)) and PEEPi (1.1+/-1.3 cmH2O). The amount of fluid removed was closely related to changes in Ppl,sw and PEEPi. We conclude that the strength of the inspiratory muscles is normal or reduced in seated cirrhotic patients. In the supine position, tense ascites results in an increase in lung elastic load and development of positive end-expiratory pressure, with a consequent overload and increased activation of inspiratory muscles. Large volume paracentesis decreases overloading and activation, but does not change the strength of the inspiratory muscles.
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PMID:Respiratory mechanics in patients with tense cirrhotic ascites. 923 Feb 57

Rank correlations between cortisol reactivity measures (baseline, 2 h stress peak and change from baseline) at 6 months and 1 year and (1) behaviors videotaped in the home cage and (2) subjectively judged personality ratings were examined in 36 juvenile tufted capuchins from birth to 6 years of age. High cortisol reactivity was associated with both lower levels of play and exploration in the home cage, and higher levels of proximity and contact with mothers. Animals with higher baseline cortisol played by themselves more, and played with other animals less, than did those with lower baselines. High cortisol reactivity, especially at 1 year of age, was also related to higher levels of dorsal carrying by mothers in the second year, when most infants are independent of mothers. Ratings on the personality traits, Aggressive, Confident, Curious, Effective and Opportunistic, were all negatively correlated with cortisol reactivity levels, while Apprehensive, Fearful, Insecure, Submissive and Tense were positively correlated with cortisol reactivity. In summary, there was a relationship between high physiological reactivity and inhibited, fearful behavior and temperament patterns not previously described in capuchins.
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PMID:Cortisol reactivity and its relation to homecage behavior and personality ratings in tufted capuchin (Cebus apella) juveniles from birth to six years of age. 1175 Jul 75