Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q86TM3 (cage)
 29,987 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A spontaneous, progressive disease occurred in a large domestic breeding colony of rhesus monkeys (Macaca mulatta). The disease was characterized by slow but continuous weight loss, alopecia, acne, facial edema, diarrhea and trauma from other monkeys. Breeding efficiency was impaired with a high incidence of abortions and stillbirths. Live offspring were small and unthrifty contributing to a high infant mortality rate. The cause of this disease was polychlorinated biphenyls (PCSs) which were present in the concrete sealant on the cage floors. Removing the sealant and resurfacing the floors alleviated the problem.
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PMID:A spontaneous outbreak of polychlorinated biphenyl (PCB) toxicity in rhesus monkeys (Macaca mulatta): clinical observations. 11 26

A colony of rabbits free from coccidia was established in 1974 by weaning young at 25 days of age from dams infected with coccidia. Until now Bordetella, Pasteurella and Psoroptes cuniculi have not been detected either, and neither diarrhea nor death has occurred in weanlings of the colony. However, the mortality of sucklings was significantly high owing to cannibalism and tread by their dams. The weaning rate was effectively improved by use of a large nursing cage (3,100 cm2) and sterilized hay on a stainless steel mesh floor of the nursing cage.
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PMID:[Establishment of a colony of Japanese white rabbits free from coccidia and their breeding performance (author's transl)]. 16 Aug 72

An outbreak of enteric form of Tyzzer's disease occurred in a golden hamster colony, and 60% of diseased animals examined were found to have severe enterocolitis without hepatic lesions. Organisms were detected within mucosal epithelial cells, especially in the lower ileum, cecum and colon showing degenerative and necrotic changes, and in some cases organisms were also detected in the smooth muscle layer. Infiltration of neutrophils and mononuclear cells in the lamina propria and submucosa was observed. Hamsters either having been cage-mates with diseased ones or given perorally cecal contents from affected animals, suffered from severe diarrhea and were shown to have necrotic foci in the liver. By intravenous inoculation with affected hamster liver homogenate into cortisone-treated mice, hepatic lesions characteristic of Tyzzer's disease were produced. Moreover, such infected mouse liver was found to cause severe diarrhea in hamsters when administered perorally.
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PMID:Transmissible enterocolitis in hamsters caused by Tyzzer's organism. 122 25

To produce physical dependence on morphine, phenobarbital and diazepam in rats, these drugs were mixed with powder form of rat food in concentrations of 0.5 mg/g, 1 mg/g and 2 mg/g of food. One group of rats (the lower dose group) was continuously exposed for 1 week to two morphine-admixed foods with morphine to food ratios of 0.5 mg/g and 1 mg/g in a cage. The other group (the higher dose group) could choose between two morphine-admixed foods with morphine to food ratios of 1 mg/g and 2 mg/g. After 1 week, morphine-admixed foods were replaced with morphine free food for 2 days. Both groups of rats showed greatly reduced body weight and food intake after the first 24-48 hr withdrawal. The body weight decrease was greater for rats in the higher dose group. Control groups of morphine dependent rats were kept on the morphine added food diets and showed the same body weight increase as well as normal control rats during the course of these experiments. Physical dependence on phenobarbital and diazepam was produced using the same dosage schedules as with morphine. Both the lower and higher dose groups showed significant decrease in body weight due to withdrawal after 1 week of drug-food exposure. Levallorphan (0.5, 1, 3 and 5 mg/kg, s.c.) administered to morphine dependent rats had dose-dependent effects on the intensity of abstinence symptoms (e.g., diarrhea, piloerection and wet shakes phenomena), maximal decrease in body weight and duration of decreased body weight. Cross-physical dependence between phenobarbital and diazepam was demonstrated by this method.
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PMID:Physical dependence on morphine, phenobarbital and diazepam in rats by drug-admixed food ingestion. 123 8

The role of rotavirus in diarrheal disease of rabbits was investigated, and a model for human rotavirus infection was established. Orogastric inoculation of 8- and 12-week-old New Zealand White rabbits with a rabbit strain of rotavirus (L:ALA:84) resulted in fecal shedding of virus for 6 to 8 days from 2 to 5 days after inoculation. Most rabbits exhibited diarrhea, coincident with the onset of viral shedding, which persisted for 2 to 4 days. Diarrhea was characterized by soft or fluid stools and fecal staining of the perineum. Inoculation of 3-week-old rabbits resulted in a briefer period of viral shedding and diarrhea of a milder nature. Histopathologic examination during the period of viral shedding revealed a mild, nonsuppurative enteritis. Inoculated rabbits exhibited antibodies in serum to rotavirus by enzyme-linked immunosorbent assay. Sham-inoculated or uninoculated rabbits maintained in the same cage or the same room with inoculated rabbits acquired rotavirus infection. The mild diarrheal disease which resulted with a rotavirus isolate from severe field cases suggests that cofactors were involved.
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PMID:Pathogenicity of rotavirus in rabbits. 283 7

Experimental studies were made with continuous hemofiltration treatment for bilaterally nephrectomized rats and initial observations regarding the effects of such treatment on leukocyte and thrombocyte counts are reported. Hemofiltration of unanesthetized rats able to move freely within their cage could be continued for up to 30 h using a pump-driven ECC system. Blood parameters recorded during this treatment indicate that the detoxification was effective. In another series of experiments the water and electrolyte reabsorption capacity of the colon ascendens of healthy rats was tested by continuously supplying NaCl solution into the colon via a fistula. A large proportion, if not all, of the hemofiltrate can be discharged into the colon without diarrhoea. A final series of experiments showed that the three-stage operation (implantation of permanent catheters, connection of a permanent intestinal fistula and bilateral nephrectomy) is possible with the rat.
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PMID:Experiments with continuous hemofiltration and hemofiltrate regeneration in the rat. 395 49

Giardia sp infection was believed responsible for chronic, intermittent diarrhea in a group of 14 Persian cats. Seven of the cats were shedding Giardia sp cysts, and 6 of these cats had diarrhea at the time of fecal examination. Conversely, only 1 of 6 clinically normal cats in the group was shedding Giardia sp cysts. Cysts were not detected in feces of 2 cats with diarrhea. Cats less than or equal to 3 years old were more likely to be found shedding cysts. The parasite apparently was eradicated from the cattery by a combination of cage disinfection (1% sodium hypochlorite solution) and oral furazolidone treatment (4 mg/kg of body weight, BID for 5 consecutive days). During treatment, clinical signs resolved, and all cats remained clinically normal 2 months after treatment.
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PMID:Giardiasis in a cattery. 403 Apr 50

SPF cats were experimentally infected orally with bovine rotavirus. All of them excreted virus over a period of at least two weeks after inoculation. Seroconversion was observed after one week for all the animals, but it did not stop viral excretion or prevent further excretion of the same or another rotavirus strain given later. Cats or dogs kept in the same cage as inoculated animals became infected and excreted virus, but seroconversion was not observed in these contact animals. None of the animals developed diarrhoea during the experiment. Cats are thus able to multiply bovine rotavirus, and transmission of this virus occurs between cats or between dogs and cats. Therefore, cats, like dogs, may play a role in the epizootiology of rotavirus infection in calves.
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PMID:Propagation of bovine rotavirus by cats and dogs. 630 66

Fifty-four Rotterdam patients in which a primary infection with Campylobacter jejuni had been detected (index patients) were compared with 54 control subjects with regard to the consumption and preparation of foods 7 days before onset of illness and the keeping of pet animals. Significantly more index patients than controls had eaten chicken meat (47 v. 29; P = 0.0002), particularly at barbecues (14 v. 2; P = 0.0015). Marginally more index patients had eaten pork (47 v. 39; P = 0.048) or inadequately heated meat (13 v. 8), though in the last case numbers were too small to be statistically significant. The consumption of beef or mutton and outdoor eating (other than at barbecues) were essentially the same in both groups. There was no significant association with the keeping of pet animals, although a few more index patients had cage birds than controls (18 v. 12). Twenty-one (15%) of 136 household contacts of index patients also suffered from diarrhoea during the same period. Circumstantial evidence pointed to a common source of infection with the index patient in 13 instances (nine households) and probable intrafamilial spread of infection in six instances. Campylobacters were isolated from one of 110 swabs of kitchen work surfaces and eight of 107 swabs taken from lavatory bowls in index households.
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PMID:Epidemiological investigations on Campylobacter jejuni in households with a primary infection. 650 78

Experimentally infecting goats with three species of coccidia (Eimeria ninakohlyakimovae, E. arloingi, E. christenseni) and placing them in metabolism cage helped us to obtain a parasitic development which was significant and continuous. This development is not necessarily accompanied by clinical symptoms. However slight constipation and not diarrhoea was observed. Feed consumption is reduced and a subsequent reduction in the rate of growth is observed. As far as the feeding behaviour is concerned, the reduction in the rate of growth is compensated by the animals choosing those parts of their ration which are most easily digested.
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PMID:Experimental coccidiosis in goats. 1. Experimental model. Effects of parasitism on the feeding behaviour and the growth of animals; intestinal lesions. 652 15


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