Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q86TM3 (cage)
 29,987 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To study renal handling of urinary electrolytes from male Fisher 344 rats during spaceflight, waste pads were obtained from cages flown in space and from cages used for ground controls. Pads were obtained from cages in which animals were group-housed (n=6 animals/cage) (Animal Enclosure Module; AEM) for 12 days or individually housed (2 animals/divided cage) (Research Animal Holding Facility; RAHF) for 19 days. Pads were washed, and extracts analyzed for sodium, potassium, chloride, calcium, and creatinine concentrations. It was observed that spaceflight reduced the absolute concentrations of electrolytes deposited onto the pads. When adjustments were made for deposition on all cage surfaces during flight, electrolyte and creatinine concentrations were similar to those of controls. Specifically, there were no differences in the sodium-, potassium-, and chloride-to-creatinine ratios of flight and control animals, suggesting no difference in the renal handling of these electrolytes during spaceflight. The calcium-to-creatinine ratio of urine on flight waste pads was reduced, suggesting an increase in reabsorption. From these analyses, the renal handling of sodium, potassium, and chloride does not appear to be altered in rats during spaceflight, while that of calcium may be. Deposition of urine on all surfaces of the cages during spaceflight should be considered in the design of future animal habitats, and in future analyses of waste pad constituents.
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PMID:Deposition and renal handling of urinary electrolytes from rats during spaceflight. 1154 83

Space flight produces changes in neuronal activity in the vestibular system. We studied the protein expression of the NMDA receptor subunit NR1 in the vestibular ganglia of rats exposed to microgravity for 17 days, beginning on postnatal day 8, as part of the NASA Neurolab mission. As a control, we studied the cochlear ganglia in the same way. NR1 expression in rats that had experienced microgravity (flight-FLT rats) was compared with that in two types of ground control. One control consisted of rats housed in regular cage conditions (VIV, vivarium); the other, asynchronous ground control (AGC), consisted of rats kept in cages similar to those used in flight (animal enclosure module, AEM), requiring no human care. After 8 days of flight, NR1 levels in the vestibular and cochlear neurons were similar in FLT, VIV and AGC rats. In contrast, 8 h after landing, the FLT and VIV animals showed similar, normal levels of NR1 staining, whereas the ganglia of the AGC animals displayed only very faint staining. Thus, microgravity did not modify NR1 expression in vestibular neurons. The lower levels of NR1 expression in the vestibular and cochlear neurons of AGC rats suggest an effect of confinement for 17 days in AEMs on the ground.
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PMID:Confinement but not microgravity alters NMDA NR1 receptor expression in rat inner ear ganglia. 1285 54

A growing body of literature supports the role of apolipoproteins present in HDL in the treatment of pro-inflammatory diseases including cancer. We examined whether bovine HDL (bHDL) and three dual-domain peptides, namely AEM-28 and its analog AEM-28-2, and HM-10/10, affect tumor growth and development in mouse models of ovarian and colon cancer. We demonstrate that bHDL inhibits mouse colorectal cancer cell line CT26-mediated lung tumor development, and mouse ovarian cancer cell line ID8-mediated tumor burden. We also demonstrate that, although to different degrees, dual-domain peptides inhibit cell viability of mouse and human ovarian and colon cancer cell lines, but not that of normal human colonic epithelial cells or NIH3T3 mouse fibroblasts. Dual-domain peptides administered subcutaneously or in a chow diet decrease CT26 cell-mediated tumor burden, tumor growth, and tumor dissemination in BALB/c mice. Plasma levels of lysophosphatidic acid (LPA) are significantly reduced in mice that received bHDL and the dual-domain peptides, suggesting that reduction by effecting accumulation and/or synthesis of pro-inflammatory lipids may be one of the mechanisms for the inhibition of tumor development by bHDL and the dual-domain peptides. Our studies suggest that therapeutics based on apolipoproteins present in HDL may be novel agents for the treatment of epithelial adenocarcinomas of the ovary and colon.
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PMID:Bovine HDL and Dual Domain HDL-Mimetic Peptides Inhibit Tumor Development in Mice. 3246 55