Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q86TM3 (cage)
 29,987 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thoracic spine (T1-T10) fractures can be considered a specific entity owing to the anatomic features of the rib cage and the spinal canal. During a nine year period, the authors treated 105 such fractures. The thoracic spine fractures included 57 (54.2 per cent) compression fractures, 21 (20 per cent) comminuted (burst) fractures, 3 (2.8 per cent) flexion-distraction fractures, and 24 (23 per cent) fracture-dislocations. Five lesions, termed "fracture-dislocations by an oblique shearing force", were characterized by considerable displacement and the absence of neurologic injury. 35.2 per cent of the patients had injuries at multiple levels. The frequency of associated thoracic (26.5 per cent) and scapular injuries (20 per cent) reflected involvement of the entire thoracic cage. The frequency of neurologic impairment (30.4 per cent including 20 per cent complete paraplegia) reflects the particular vulnerability of the dorsal spinal cord. 32 per cent of the patients presented one or more thoracic effusions (hemomediastinum, hemothorax) related to parietal hematoma and/or hematoma at the fracture site. Functional management of 47 patients led to recovery of a painless spine without kyphotic deformity. Conservative treatment was often difficult because of associated parietal lesions; the 10 patients treated in this manner had only moderate reductions that maintained poorly in time, but had no major painful sequellae. A posterior approach was used for 42 patients with unstable or neurotoxic fractures because this permitted a complete decompression down to the posterior wall, when necessary by a "wide laminectomy". The anterior approach was reserved for purely anterior compression (3 cases) or residual compression after an initial posterior procedure (2 cases). Cotrel-Dubousset instrumentation (used in 7 cases) was particularly indicated because it offers the advantages of Harrington rods (31 cases) while providing better stabilization. This prevented later loss of reduction and obviated the need for a postoperative brace.
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PMID:[Fractures of the thoracic spine (T1-T10). Apropos of 105 cases]. 259 50

The thoracic spine is different from other mobile segments of the spine because of the presence of ribs and their articulations. The rib cage makes the thoracic spine much more stable and, during trauma, provides additional strength and energy-absorbing capacity. This leads to the conclusion that severe trauma is required to damage the thoracic spine, and the skeletal injury is usually evident on radiographs. A spontaneous reducible vertebral luxation (dislocation) is not easy to identify, even with magnetic resonance (MR) imaging. Subtle changes in thoracic spine osseous injuries are not seen on radiographs but may be demonstrated on computed tomography (CT) scans. MR imaging can also demonstrate the posterior ligamentous lesions. In this study, we present three cases of thoracic spinal cord changes without spinal fracture and one disk herniation (degenerative chronic disease). These patients had a permanent neurologic deficit (complete paraplegia); plain radiographs and CT scans showed nothing abnormal. MR imaging showed lesions in the thoracic spinal cord and, in one case, a posttraumatic disk herniation. In cases of post-traumatic cord lesions, MR imaging provides diagnostic information that appears to exceed other imaging modalities. The existence of a neurologic deficit indicates MR as the first examination in cases of traumatic spinal lesions.
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PMID:Posttraumatic spinal cord lesions without skeletal or discal and ligamentous abnormalities: the role of MR imaging. 972 6