Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q86TM3 (cage)
 29,987 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

PCB translocation from soil into a plant through its roots was investigated by a method of culture of soybean sprouts on sand contaminated with Aroclor 1242 or 1254. A preliminary culture was carried out on clean sand in a cage with small holes in the bottom and then followed by a main culture on contaminated sand after the preliminary culture cage was placed upon a box filled with the contaminated sand. Consequently, roots of soybean sprouts were allowed to penetrate through the holes at the botton of the upper cage into the contaminated sand. Rates of transference of PCBs were found to be different among chlorobiphenyl isomers; low chlorobiphenyls were much more preferentially absorbed by sprouts that were the high chlorobiphenyls. This seemed to depend mostly on different water solubilities of the isomers and probably not on selective absorption of the isomers by sprouts. The usefulness of the method employed of the two-steps sprout culture on doubly layered soil, in investigations of translocation mechanisms of toxic chemicals in a soil-plant ecosystem, is also discussed.
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PMID:Translocation of polychlorobiphenyls in soil into plants: a study by a method of culture of soybean sprouts. 40 32

A perchlorinated, cage-structured hydrocarbon, C(10)C(l2), also known as mirex or Dechlorane, has been identified in fish samples from the Bay of Quinte, Lake Ontario, Canada. The compound coelutes with polychlorinated biphenyls (PCB's) in residue cleanup procedures and under standard gas chromatographic conditions. Mirex has never been registered for use as an insecticide in Canada, nor does it appear to be in use in any area of the United States discharging water into Lake Ontario or its tributaries. It seems likely, therefore, that this compound is another widespread environmental contaminant of extremely high geochemical stability and as yet only superficially investigated biological activities. Under standard gas chromatographic conditions its peak is superimposed on that of the PCB's, and, as a result, the presence of mirex may have been unrecognized and it may therefore have been misinterpreted as a PCB isomer.
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PMID:Mirex: an unrecognized contaminant of fishes from Lake Ontario. 484 Nov 56

Various aspects of locomotor activity were measured, using a crossed photobeam cage, in young rhesus monkeys (M. mulatta) whose mothers had been fed low levels of polychlorinated biphenyls (PCBs, Aroclor 1248) both before and during gestation and nursing. In Exp. 1, a group of young monkeys whose mothers had been fed 2.5 ppm PCBs (the 2.5 ppm concurrent-exposure group) was compared with the control group of Exp. 1 at 6 (Exp la) and 12 (Exp lb) mon of age. In Exp. lla, a group of young monkeys born from the same 2.5 ppm mothers after they had been off their 2.5 ppm PCB diets for periods ranging from 0.5 to 1.5 yr (i.e., the 2.5 ppm post-exposure group) was compared with the control group of Exp. II at 12 mon of age. In Exp. IIb, two groups of young monkeys from groups of mothers fed 0.5 and 1.0 ppm PCBs three times per week (concurrent-exposure) were compared at 12 mon of age with the control group of Exp. II. In the 12-mon tests the mean data and variability of the two control groups were very similar, both in their mean locomotor activity levels in early sessions and in activity at about half that level in later sessions, suggesting between-session adaptation over the course of the experiment. In contrast, both the concurrent and the post-exposure 2.5 ppm groups showed between-session patterns which began at control activity levels but which rose to levels at least three times those of the controls by the final sessions. In the tests conducted at 12 mon of age, locomotor activity for 15 min periods within each daily session were within measurement error of being stable for all groups except the 0.5 and 1.0 ppm groups of Exp. llb. The former exhibited increasing activity throughout each session, a pattern which persisted across all 24 sessions run. On the other hand, the 1.0 ppm group showed within-session decrements which became less pronounced as the experiment continued. This latter pattern was the only one shown by any group which was consistent with the concept of "reactivity". Overall, all of the PCB-treated groups were more active than their controls with no quantitative difference related to PCB dosage. Dose-effect differences appeared in the form of qualitatively different activity patterns between the groups, for which no quantitative description appeared obvious.
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PMID:Locomotor hyperactivity in PCB-exposed rhesus monkeys. 679 10

Two cases with cervical discopathy and radiculopathy are presented. Discectomy and anterior interbody fusion with cage-plate PCB manufactured by French company Scient'x was performed. Authors present the shape of the implant and technical details of implantation. The paper discusses the advantages of the PCB which simplifies and shortens the operation procedure, minimizes the risk of traditional bone graft harvesting and provides immediate stabilization of the operated segment.
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PMID:[Anterior interbody fusion of cervical spine with case-plate PCB]. 1198 12

A synthetic sequence involving the initial reaction of a substituted phosphorus dihalide (RPCl(2), R = CH(3), C(6)H(5)) with the arachno-CB(8)H(13)(-) (1-) monoanion followed by an in situ dehydrohalogenation reaction initiated by Proton Sponge, resulted in phosphorus cage insertion to yield the first 10-vertex arachno- and nido-phosphamonocarbaboranes, exo-6-R-arachno-6,7-PCB(8)H(12) (2a, 2b) and PSH(+)6-R-nido-6,9-PCB(8)H(9)(-) (PSH+3a-, PSH+3b-) (R = C(6)H(5) (a), CH(3) (b)). Alternatively, 2a and 2b were synthesized in high yield as the sole product of the reaction of the arachno-4-CB(8)H(12)(2-) (1(2-)) dianion with RPCl(2). Crystallographic determinations of PSH+3a- and PSH+3b- in conjunction with DFT/GIAO computational studies of the anions have confirmed the expected nido cage framework based on an octadecahedron missing the six-coordinate vertex. DFT/GIAO computational studies have also shown that while the gross cage geometries of the exo-6-R-arachno-6,7-PCB(8)H(12) compounds 2a and 2b resemble the known isoelectronic arachno-6,9-SCB(8)H(12), the phosphorus and carbon atoms are in thermodynamically unfavorable adjacent positions on the six-membered puckered face. They also each have an endo-hydrogen at the P6-position arising from proton transfer to the basic phosphorus during the cage-insertion reaction. Possible stepwise reaction pathways that can account for the formation of both the arachno and nido products are discussed. Deprotonation of 2a and 2b resulted in the formation of their corresponding conjugate monoanions, 6-R-arachno-6,7-PCB(8)H(11)(-) (2a-, 2b-), in which the proton that had been attached to the P6 atom was removed. Reactions of 2a- with O(2), S(8), BH(3).THF, or Br(2) further demonstrated the basicity of the P6-phosphorus yielding the new arachno-substituted compounds, endo-6-O-exo-6-(C(6)H(5))-arachno-6,7-PCB(8)H(11)(-) (4a-), endo-6-S-exo-6-(C(6)H(5))-arachno-6,7-PCB(8)H(11)(-) (5a-), endo-6-BH(3)-exo-6-(C(6)H(5))-arachno-6,7-PCB(8)H(11)(-) (6a-), and endo-6-Br-exo-6-(C(6)H(5))-arachno-6,7-PCB(8)H(11) (7a), respectively, in which the O, S, BH(3), and Br substituents are bound to the phosphorus at the endo position.
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PMID:Syntheses, crystallographic/computational characterizations, and reactions of the first 10-vertex arachno- and nido-phosphamonocarbaboranes. 1251 23

Deprotonation of the phosphamonocarbaborane, exo-6-R-arachno-6,7-PCB(8)H(12) (R = Ph 1a or Me 1b), yields exo-6-R-arachno-6,7-PCB(8)H(11)(-), which when reacted with appropriate transition-metal reagents affords new metallaphosphamonocarbaborane complexes in which the metals adopt endo-eta(1), exo-eta(1), eta(4), eta(5), or eta(6) coordination geometries bonded to the formal R-arachno-PCB(8)H(11)(-), R-arachno-PCB(8)H(10)(2-), R-arachno-PCB(8)H(9)(3-), or R-nido-PCB(8)H(9)(-) ligands. The reaction of exo-6-(C(6)H(5))-arachno-6,7-PCB(8)H(11)(-) (1a-) with Mn(CO)(5)Br generated the eta(1)-sigma product exo-6-[Mn(CO)(5)]-endo-6-(C(6)H(5))-arachno-6,7-PCB(8)H(11) (2) having the [Mn(CO)(5)] fragment in the thermodynamically favored exo position at the P6 cage atom. On the other hand, reaction of 1a- with (eta(5)-C(5)H(5))Fe(CO)(2)I resulted in the formation of two products, an eta(1)-sigma complex endo-6-[(eta(5)-C(5)H(5))Fe(CO)(2)]-exo-6-(C(6)H(5))-arachno-6,7-PCB(8)H(11) (3) having the (eta(5)-C(5)H(5))Fe(CO)(2) fragment attached at the endo-P6 position and an eta(6)-closo complex, 1-(eta(5)-C(5)H(5))-2-(C(6)H(5))-closo-1,2,3-FePCB(8)H(9) (4a). Rearrangement of the endo-compound 3 to its exo-isomer 5 was observed upon photolysis of 3. Synthesis of the methyl analogue of 4a, 1-(eta(5)-C(5)H(5))-2-CH(3)-closo-1,2,3-FePCB(8)H(9) (4b), along with a double-insertion product, 1-CH(3)-2,3-(eta(5)-C(5)H(5))(2)-2,3,1,7-Fe(2)PCB(8)H(9) (6), containing two iron atoms eta(5)-coordinated to a formal R-arachno-PCB(8)H(9)(3-), was achieved by reaction of exo-6-CH(3)-arachno-6,7-PCB(8)H(11)(-) (1b-) with FeCl(2) and Na(+)C(5)H(5)(-). Complexes 4a and 4b can be considered ferrocene analogues, in which an Fe(II) is sandwiched between C(5)H(5)(-) and 6-R-nido-6,9-PCB(8)H(9)(-) anions. Reaction of exo-6-(C(6)H(5))-arachno-6,7-PCB(8)H(11)(-) (1a-) with cis-dichlorobis(triphenylphosphine)platinum (II) afforded two compounds, an eta(1)-sigma complex with the metal fragment again in the endo-P6 position, endo-6-[cis-(Ph(3)P)(2)PtCl]-exo-6-(C(6)H(5))-arachno-6,7-PCB(8)H(11) (7) and an eta(4)-complex, 7-(C(6)H(5))-11-(Ph(3)P)(2)-nido-11,7,8-PtPCB(8)H(10) (8) containing the formal R-arachno-PCB(8)H(10)(2)(-) anion. The structures of compounds 2, 3, 4a, 4b, 6, 7, and 8 were crystallographically confirmed.
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PMID:Syntheses and structural characterizations of endo-eta(1)-, exo-eta(1)-, eta(4)-, eta(5)-, and eta(6)-metallaphosphamonocarbaborane complexes derived from a versatile new polyborane ligand: exo-6-R-arachno-6,7-PCB(8)H(12). 1251 24

Anterior cervical discectomy and fusion, as originally described by Robinson, is highly successful in the treatment of neural compression caused by disc material or osteophytes. Although the necessity for fusion after anterior cervical discectomy is still debated, anterior cervical fusion with interbody bone graft and anterior plate implantation is a commonly accepted procedure. In this study, preliminary results with a recently developed PCB cervical plate system (SCIENT'X, Paris, France), which combines a hollow intradiscal cage with an integrated plate, in the management of cervical disc disease are reported.
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PMID:Anterior cervical fusion with the PCB cage-plate system. 1519 Nov 54

The aim of this study is to evaluate an integrated cage and plate device (the plate cage Benezech, PCB) filled with autogenous bone in anterior cervical discectomy and fusion. The fused segment height, lordosis, and fusion were assessed by postoperative radiographic examination at different intervals. Patients were evaluated using Odom's criteria and the Short Form (SF)-36 Health Survey questionnaire. The mean follow-up duration was 4.1 years. Fusion was achieved in 90.0%, 96.0% and 100% of patients at 3 months, 6 months and at final visit, respectively. The fused segment height and lordosis were restored and maintained. Cage subsidence (3mm) occurred at one level and settling was observed at three levels. An excellent-to-good result was achieved in 81.8% of patients. The data from the SF-36 questionnaire revealed significant postoperative improvement (p<0.01) except for social function and mental health. This study suggests that patients instrumented with PCB can obtain good radiographic and clinical results and that PCB is a safe and effective device in cervical anterior fusion.
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PMID:Use of an integrated anterior cervical plate and cage device (PCB) in cervical anterior fusion. 1968 29

The dehydrogenation of semiconducting boron carbide (B(10)C(2)H(x)) films as well as the three closo-carborane isomers of dicarbadodecaborane (C(2)B(10)H(12)) and two isomers of the corresponding closo-phosphacarborane (PCB(10)H(11)) all appear to be very similar. Photoionization mass spectrometry studies at near-threshold gas phase photoionization indicate that the preferred pathway for dissociation of the parent cation species (C(2)B(10)H(10)(+) or PCB(10)H(9)(+)) is, in all cases, the loss of H(2). Ab initio density functional theory (DFT) calculations indicate that energetically preferred sites for exopolyhedral hydrogen (B-H) bond dissociation are in all cases at B atoms opposite the C atoms in the parent cage molecule. The site of photodissociation of hydrogen from semiconducting boron carbide (B(10)C(2)H(x)) films, fabricated by plasma-enhanced chemical vapor deposition, is a cage boron atom that can bond to nitrogen upon exposure to VUV light in the presence of NH(3). Shifts in core level binding energies due to nitrogen bond formation indicate that B-N bond formation occurs only at B atoms bound to other boron atoms (B-B sites) and not at B-C sites or at C sites, in agreement with gas phase results.
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PMID:Photofragmentation of the closo-carboranes part II: VUV assisted dehydrogenation in the closo-carboranes and semiconducting B10C2H(x) films. 2056 97

The aim of this study was to analyze treatment results of patients who underwent cervical fusion using plate cage PCB Evolution during 2 year period. 37 hybrid cages (titanium plate and PEEK cage) were implanted to 34 patients with degenerative disease of cervical spine. Assessment of results was performed by neurologic examination, neurovisualization data, visual analogue pain scale and Neck Disability Index. Mean duration of surgery was 92 min., blood loss - 42 ml, length of hospital stay - 8 days. Substantial decrease of frequency and intensity of neck and arm pain was observed after surgery in 91% of patients. Single asymptomatic complication occurred due to improper implant position owing to loosening of the upper screw. When properly performed, anterior cervical interbody fusion applying PCB Evolution plate cage is a simple and effective method with low complication rate.
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PMID:[Analysis of anterior cervical spondylodesis using plate cage PCB Evolution for a 2 year period]. 2365 19


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