Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q86TM3 (cage)
 29,987 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cancer and cervical disease occur more frequently in HIV infected women than in HIV negative. HIV infection is associated with an increased prevalence and severity of Human Papilloma Virus (HPV) associated cervical intraepithelial lesions. Advanced HIV disease is the strongest independent risk factor for cancer associated HPV infection. Up to now, there have been limited and controversial data on the effect of High Active Antiretroviral Therapy (HAART) on the natural history of cervical lesions. The major risk factors associated with cervical cancer detection are similar in HIV positive and negative women and include lack of screening and prolonged duration of symptoms. HIV positive women should have a complete gynaecological examination, including a Pap test, which should be performed twice in the first year after the diagnosis of HIV infection. Referral for colposcopy and biopsy should be recommended in case of abnormal cytology.
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PMID:Cervical disease and cancer in HIV positive women. Recommendations for screening and diagnosis. 1501 May 58

Cancer is a worldwide public health problem causing increasing morbidity and mortality, particularly in the developing world. Underlying trends are changing the pattern of cancer and this is also being influenced by the HIV/AIDS pandemic, particularly in Sub-Saharan Africa. Even though the pattern of cancer varies across Africa, there are identifiable trends. Breast and cervical cancers, and Kaposi sarcoma are the commonest cancers in women, while Kaposi sarcoma, liver and prostate cancers are the commonest in men. Cancer causes more morbidity and mortality in Africa compared to other parts of the world. Infections account for a disproportionate amount of cancers in Africa. The HIV epidemic is contributing to increased prevalence of many cancers particularly those associated with Herpes and Papilloma viruses. Tobacco use, another major carcinogen, is increasing, particularly among the young. Dietary factors, alcohol use, physical inactivity and environmental pollution are also important aetiological factors of cancer in Africa. In developing countries, poverty, limited government health budget and poor health care systems complicate cancer prevention, treatment and outcomes. Coordinated response by international agencies and NGOs is needed to help developing countries and several successful models exist. More action is also needed on ensuring safety and quality of chemotherapy and the price needs to be reduced. Responses advocated for cancer control in Africa include banning tobacco use, better regulation of alcohol sale, better environmental planning and immunization against cancer associated viruses. Training of health care workers to diagnose cancer and treat it effectively within limited budgets is needed. Research to develop these new treatments and others, particularly from natural products is urgently needed and this can be done safely within established health research ethics regulatory frameworks. Several opportunities for collaborative research and training include an update of the epidemiology of cancers in African females; the relationship between HIV and other carcinogenic viruses; biological factors making cancers in Africa more lethal; cheaper vaccines that will be more available and easier to store and hence can be included in the immunization programme in African countries and development of vaccines like the HPV against other uncommon serotypes of the virus.
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PMID:Cancer in Africa: opportunities for collaborative research and training. 2022 33

Despite recent advances in the development of novel therapies, esophageal carcinoma remains an aggressive cancer associated with a poor prognosis. The lack of a high throughput, reproducible syngeneic animal model that replicates human disease is partly responsible for the paucity of novel therapeutic approaches. In this report, we present the first successful syngeneic, orthotopic model for esophageal cancer. This model was used to test an established adenoviral-based tumor vaccine. We utilized a murine esophageal cancer cell line established from the ED-L2-cyclin D1;p53 mouse that was transduced to express a viral tumor antigen, the Human Papilloma Virus (HPV) E7 protein. The tumor was established in its natural microenvironment at the gastroesophageal junction. Tumor growth was consistent and reproducible. An adenoviral vaccine to E7 (Ad.E7) induced an E7-specific population of functionally active CD8 T cells that trafficked into the tumors and retained cytotoxicity. Ad.E7 vaccination reduced local tumor growth and prolonged overall survival. These findings suggest that orthotopic tumor growth is a reasonable preclinical model to validate novel therapies.
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PMID:Adenoviral-based immunotherapy provides local disease control in an orthotopic murine model of esophageal cancer. 2481 Jun 40