Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q86TM3 (cage)
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A field investigation was conducted to study the thermoregulatory responses in nine Japanese macaques (Macaca fuscata) living in a snowy mountain area, Jigoku-Dani (Hell Valley, about 1,000 m above sea level) in Shiga Heights in central Japan in late January 1975. At about the same time, a laboratory study was made on four Japanese macaques reared in mild climate in an outdoor cage in Inuyama City. In the Hell Valley (HV) monkeys, no significant change in metabolic rate was observed at Ta between -1.4 and 28.3 degrees C, while the rectal temperature was maintained at normal level. In the cold environment, the skin temperatures of HV monkeys were significantly higher than those of the monkeys living indoors previously studied. Similar patterns of metabolic and thermal responses were observed in Inuyama monkeys living outdoors, but to a lesser degree. The hair on the back and abdomen in the HV monkeys was significantly longer than that of Iuyama monkeys living indoors. It is suggested that the thick fur of HV monkeys may account for, if not all, the thermoregulatory responses of the Japanese macaque in snowy mountain areas.
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PMID:Thermoregulation of the Japanese macaque living in a snowy mountain area. 41 Sep 88

We examined how Japanese monkeys in the wild formed an aversion to food which had been paired with poison. Ten monkeys of various ages and both sexes were chosen as subjects from 105 members of the Shiga-A1 troop at Jigokudani in Shiga Heights in Japan. We gave almond nuts to each subject. Once a monkey ate 10-20 almond nuts, he was captured and moved into an injection cage. Seven experimental subjects were injected intravenously with cyclophosphamide (20 mg/kg). Three control subjects received the same treatment except that they were injected with physiological saline. About 1 hour later, all subjects were released into the troop. The tests for conditioned aversions were conducted during the next 2 days. In the tests, the experimental subjects would not eat almond nuts, while the control subjects showed no hesitation in eating them. Five of the seven experimental subjects retained perfectly the aversion to almond nuts in tests conducted 1 month and 3 months later. The one-trial long-lasting food-aversion learning shown by the wild Japanese monkeys is discussed in terms of their feeding strategy. These results also suggest that food-aversion conditioning has potential as a nonlethal method for controlling crop-raiding monkeys.
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PMID:One-trial long-lasting food-aversion learning in wild Japanese monkeys (Macaca fuscata). 667 Sep 70

Clostridium difficile is the main cause of antibiotic-associated diarrhea and pseudomembranous colitis in humans and animals. Its pathogenicity is primarily linked to the secretion of two exotoxins (TcdA and TcdB). Although great progress in the toxic mechanism of TcdA and TcdB has been achieved, there are many conflicting reports about the apoptotic mechanism. More importantly, apoptotic endoplasmic reticulum (ER) stress has been reported in cells treated with Shiga toxins-another kind of cytotoxins that can cause diarrhea and colitis. Herein we checked whether TcdB can induce ER stress. The results showed that recombinant TcdB (rTcdB) activated molecular markers of unfolded protein response, suggesting that rTcdB induced ER stress in CT26 cells. However, rTcdB did not induce the up-regulation of C/EBP homologous protein (CHOP), a classic mediator of apoptotic ER stress, but it activated the precursor of cysteine aspartic acid-specific protease 12 (caspase-12), a controversial mediator of apoptotic ER stress. Besides, glucosyltransferase activity-deficient mutant recombinant TcdB induced ER stress, though it has no cytotoxic or cytopathic effect on CT26 cells. Altogether, these data demonstrated that ER stress induced by rTcdB is glucosyltransferase-independent, indicating that ER stress induced by rTcdB is non-apoptotic. This work also offers us a new insight into the molecular mechanism of CHOP protein expression regulation and the role of CHOP expression in ER stress.
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PMID:Recombinant Clostridium difficile toxin B induces endoplasmic reticulum stress in mouse colonal carcinoma cells. 2527 32